Temperature-sensitive transformation by an abelson virus mutant encoding an altered SH2 domain

Journal of Virology

Volumn 75, Issue 4, 2001, Pages 1816-1823

  Mainville, C A ^a   Parmar, K ^a   Unnikrishnan, I ^a   Gong, L ^a   Raffel, G D ^a   Rosenberg, N ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; LYSINE; MUTANT PROTEIN; PROTEIN SHC; PROTEIN TYROSINE KINASE; RAS PROTEIN;

ABELSON MURINE LEUKEMIA ONCOVIRUS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL STRAIN; ENZYME ACTIVITY; FIBROBLAST CULTURE; GENE EXPRESSION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TEMPERATURE DEPENDENCE; VIRUS CELL TRANSFORMATION; VIRUS CHARACTERIZATION;

3T3 CELLS; ABELSON MURINE LEUKEMIA VIRUS; ANIMALS; B-LYMPHOCYTES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; GENES, VIRAL; LEUKEMIA, PRE-B-CELL; MICE; MUTATION; ONCOGENE PROTEINS V-ABL; PREMENOPAUSE; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TEMPERATURE;

EID: 0035135726     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.4.1816-1823.2001     Document Type: Article

References (52)

1. Differential complementation of Bcr-Abl point mutants with c-Myc
2. Correlation between D region structure and antigen-binding specificity: Evidences for the comparison of closely related immunoglobulin VH sequences
3. Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides
4. Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase
5. Mutational investigation of the specificity determining region of the Src SH2 domain
6. Site-directed mutagenesis of the src gene of Rous sarcoma virus: Construction and characterization of a deletion mutant temperature sensitive for transformation
7. p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells
8. Lymphoid cells transformed by Abelson virus require the v-abl protein tyrosine kinase only during early G1
9. An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement
10. Characterization of mouse monoclonal antibodies specific for friend murine leukemia virus-induced erythroleukemia cells: Friend-specific and FMR-specific antigens
11. Modular binding domains in signal transduction proteins
12. Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis
13. Linker insertion-deletion mutagenesis of the v-src gene: Isolation of host- and temperature-dependent mutants
14. The GRB2/Sem-5 adaptor protein
15. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system
16. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
17. bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation
18. Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity
19. Versatile retroviral vectors for potential use in gene therapy
20. Bcw/ABL is not required for the transformation of hematopoietic factor-dependent cells
21. Signal transduction from multiple Ras effectors
22. Cell cycle targets of Ras/Raf signaling
23. Increasing complexity of Ras signal transduction: Involvement of Rho family proteins
24. The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases
25. The BCR-ABL oncogene transforms Rat-1 ceils and cooperates with v-myc
26. SH2 domain specificity and activity modified by a single residue
27. Ras effectors
28. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo
29. Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells
30. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosomepositive human leukemias
31. v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation
32. Ras complements the carboxyl terminus of v-Abl protein in lymphoid transformation
33. SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence
34. Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation
35. In vivo association of v-Abl with Shc mediated by a non-phosphotyrosine-dependent SH2 interaction
36. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus
37. The viral and cellular forms of the Abelson (abl) oncogene
38. Dominant negative myc blocks transformation by abl oncogenes
39. Genetic requirement for ras in the transformation of fibroblasts and hematopoietic cells by the bcr-abl oncogene
40. Direct transformation of 3T3 cells by Abelson murine leukemia virus
41. Monoclonal antibodies specific for v-abl- and c-abl-en coded molecules
42. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3K/Akt-dependent pathway
43. SH2 domains recognize specific phosphopeptide sequences
44. Reduced phosphotyrosine binding by the v-Src SH2 domain is compatible with wild-type transformation
45. p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells
46. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation induced cell death
47. v-src restricts transformation in a host-dependent manner
48. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms
49. The carboxyl terminus of v-Abl protein can augment SH2 domain function
50. A role for c-Abl in c-myc regulation
51. Identification of the Abl- and ras-GAP-associated 62 kDa protein as a docking protein
52. Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases