Simultaneous treatment with 1-β-D-arabinofuranosylcytosine and daunorubicin induces cross-resistance to both drugs due to a combination-specific mechanism in HL60 cells

Cancer Research

Volumn 61, Issue 1, 2001, Pages 172-177

  Takemura, H ^a   Urasaki, Y ^a   Yoshida, A ^a   Fukushima, T ^a   Ueda, T ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; CYTARABINE; CYTIDINE DEAMINASE; DAUNORUBICIN; DEOXYCYTIDINE KINASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GLUTATHIONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL MEMBRANE POTENTIAL; CELL STRAIN HL 60; CONTROLLED STUDY; CROSS RESISTANCE; DRUG ACCUMULATION; ENZYME ACTIVITY; ENZYME ASSAY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MYELOID LEUKEMIA; PRIORITY JOURNAL;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ATP-BINDING CASSETTE TRANSPORTERS; BCL-X PROTEIN; BUTHIONINE SULFOXIMINE; CYTARABINE; CYTIDINE DEAMINASE; DAUNORUBICIN; DEOXYCYTIDINE KINASE; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG RESISTANCE, MULTIPLE; GLUTATHIONE; HL-60 CELLS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 0035135720     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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