Cadmium chloride-induced dysplastic changes in the ventral rat prostate: An immunohistochemical and quantitative study

Prostate

Volumn 46, Issue 1, 2001, Pages 11-20

  Anidjar, Maurice ^a   Villette, Jean Marie ^b,c   Devauchelle, Patrick ^c   Delisle, Franoise ^d   Cotard, Jean Pierre ^e   Billotey, Claire ^f   Cochand Priollet, Beatrix ^g   Copin, Henri ^h   Barnoux, Muriel ^c   Triballeau, Sylvie ^a   Rain, Jean Didier ^b   Fiet, Jean ^c   Teillac, Pierre ^d   Berthon, Philippe ^e   Cussenot, Olivier ^f  

^a Centre de Recherche pour les Pathologies Prostatiques   (France)

^b Service d'Urologie   (France)

^c Laboratoire de Biologie Hormonale   (France)

^d ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^e Service de Mdecine Nuclaire   (France)

^f Service d'Anatomopathologie   (France)

^g Service d'Histologie Embryologie   (France)

^h INSTITUT UNIVERSITAIRE DE FRANCE   (France)

Author keywords

Cadmium; Dysplasia; Immunohistochemistry; Intraepithelial neoplasia; Rat prostate

Indexed keywords

CADMIUM CHLORIDE; CYCLINE; DNA FRAGMENT; DRINKING WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL POPULATION; CELL PROLIFERATION; CYTOTOXICITY; DYSPLASIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS; RAT;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CADMIUM CHLORIDE; CELL DIVISION; DNA FRAGMENTATION; EPITHELIUM; GENES, BCL-2; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR;

EID: 0035134337     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0045(200101)46:1<11::AID-PROS1003>3.0.CO;2-K     Document Type: Article

References (38)

1. Prostatic intraepithelial neoplasia (PIN): Current concepts
2. The relationship between prostatic intraepithelial neoplasia and prostate cancer: Critical issues
3. Bcl-2 immunoreactivity in prostate tumorigenesis in relation to prostatic intraepithelial neoplasia, grade, hormonal status, metastatic growth and survival
4. Immunohistochemical analysis of bcl-2, bax, bcl-X and mcl-1 expression in prostate cancers
5. Progression of prostatic intraepithelial neoplasia to early invasive adenocarcinoma
6. Biomarker expression in prostatic intraepithelial neoplasia
7. Quantitative characterization of the frequency and location of cell proliferation and death in prostate pathology
8. Potential markers of prostate cancer aggressiveness detected by fluorescence in situ hybridization
9. Intravenous versus intraprostatic administration of N-methyl-N-nitrosourea to induce prostate cancer in rats
10. Induction at high incidence of ductal prostate adenocarcinomas in NBL/Cr and Sprague-Dawley Hsd:SD rats treated with a combination of testosterone and estradiol-17β or diethylestilbestrol
11. Effects of testosterone, dihydrotestosterone and estrogen on 3,2-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis
12. Animal models for the study of prostatic carcinogenesis
13. Animal models for the preneoplastic lesions of the prostate
14. Expression of bcl-2 and the progression of human and rodent prostatic cancers
15. Progression of prostatic intraepithelial neoplasia to invasive carcinoma in C3(1)/SV40 large J antigen transgenic mice: Histopathological and molecular biological alterations
16. Cadmium carcinogenesis in review
17. Carcinogenicity of oral cadmium in the male Wistar (WF/NCr) rat: Effect of chronic dietary zinc deficiency
18. Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis
19. Bcl-2: Role in epithelial differentiation and oncogenesis
20. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
21. Evaluation of proliferating cell nuclear antigen (PCNA) as an endogenous marker of cell proliferation in rat liver: A dual-stain comparison with 5-bromo 2′ deoxyuridine
22. Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5a-reductase inhibitor finasteride
23. Analysis of cell death and cell proliferation in embryonic stages, normal adult, and aging prostates in human and animals
24. NIH image: A public domain image processing program for the Macintosh
25. 2 administration. A contribution towards etiology of the cancer of the prostate
26. Gross and microscopic pathology of induced prostatic complex tumours arising in Lobund-Wistar rats
27. Volume-weighted mean nuclear volume in dysplastic glands from the ventral prostate of rats treated with cadmium chloride, and resembling human prostatic intraepithelial neoplasia
28. Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation
29. Cell proliferation and bcl-2 protein immunoexpression in dysplastic lesions induced by chronic exposure to cadmium chloride in rat ventral prostate
30. Toxicological principles of metal carcinogenesis with special emphasis on cadmium
31. Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation
32. Down regulation of bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract
33. Inhibition of caspases inhibits the release of apoptotic bodies: bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis
34. Relation between bcl-2, cell proliferation and the androgen receptor status in prostate tissue and precursors of prostate cancer
35. Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis
36. Histology and cellular kinetics of prostatic atrophy
37. Proliferative inflammatory atrophy of the prostate. Implications for prostatic carcinogenesis