T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow-up study

European Journal of Neurology

Volumn 8, Issue 1, 2001, Pages 37-42

  Sailer, Michael ^a   Losseff, N A ^b   Wang, L ^b   Gawne Cain, M L ^b   Thompson, A J ^b   Miller, D H ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Atrophy; Disability; Magnetic resonance imaging; Multiple sclerosis; T1 hypointense abnormalities

Indexed keywords

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN EDEMA; BRAIN SIZE; CLINICAL ARTICLE; CORRELATION FUNCTION; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; ENCEPHALITIS; FEMALE; FOLLOW UP; HUMAN; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL DISABILITY; PRIORITY JOURNAL; QUALITATIVE DIAGNOSIS; TISSUE INJURY;

ADULT; ATROPHY; BRAIN; DISABILITY EVALUATION; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROSPECTIVE STUDIES;

EID: 0035128314     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2001.00147.x     Document Type: Article

References (26)

1. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis
2. The characterization of experimental gliosis by quantitative nuclear magnetic resonance imaging
3. Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging with lesion pathology
4. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis
5. Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis
6. Serial contrast-enhanced magnetic resonance imaging in patients with early relapsing-remitting multiple sclerosis: Implications for treatment trials
7. Magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis
8. Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
9. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
10. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
11. Assessment of demyelination, edema, and gliosis by in vivo determination of T1 and T2 in the brain of patients with acute attack of multiple sclerosis
12. Remyelination in multiple sclerosis
13. Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression
14. Progressive cerebral atrophy in multiple sclerosis. A serial MRI study
15. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy
16. The role of magnetic resonance techniques in understanding and managing multiple sclerosis
17. Precision and reliability for measurement of change in MRI lesion volume in multiple sclerosis: A comparison of two computer assisted techniques
18. Histopathology of multiple sclerosis lesions detected by magnetic resonance imaging in unfixed postmortem central nervous system tissue
19. Magnetic resonance imaging changes with recombinant human interferon-beta-1a: A short term study in relapsing-remitting multiple sclerosis
20. Quantitative brain MRI in patients presenting with clinically isolated syndromes suggestive of demyelination
21. Axonal transection in the lesions of multiple sclerosis
22. Accumulation of hypointense lesions ('black holes') on T1 spin-echo MRI correlates with disease progression in multiple sclerosis
23. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double-blind, placebo-controlled. MR-monitored phase II trial
24. Correlating MRI and clinical disease activity in multiple sclerosis: Relevance of hypointense lesions on short-TR/short-TE (T1-weighted) spin-echo images
25. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis
26. Development of hypointense lesions on T1-weighted spin-echo magnetic resonance images in multiple sclerosis: Relation to inflammatory activity