Fusogenic activity of vesicular stomatitis virus glycoprotein plasmid in tumors as an enhancer of IL-12 gene therapy

Cancer Gene Therapy

Volumn 8, Issue 1, 2001, Pages 55-62

  Eslahi, Nima K ^a   Muller, Susanne ^a   Nguyen, Long ^a   Wilson, Elizabeth ^a   Thull, Nikki ^a   Rolland, Alain ^a   Pericle, Federica ^a  

^a Urigen Pharmaceuticals Inc   (United States)

Author keywords

Cancer immunotherapy; Fusogenic activity; Gene therapy; IL 12; VSVG

Indexed keywords

GREEN FLUORESCENT PROTEIN; INTERLEUKIN 12; POVIDONE; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SYNCYTIUM; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; COLONIC NEOPLASMS; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; FEMALE; GENE THERAPY; GIANT CELLS; GRAFT REJECTION; GREEN FLUORESCENT PROTEINS; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-12; KIDNEY NEOPLASMS; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; PLASMIDS; POVIDONE; VIRAL ENVELOPE PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE; VESICULAR STOMATITIS VIRUS;

EID: 0035125507     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700270     Document Type: Article

References (26)

1. Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity
2. The pathway of vesicular stomatitis entry leading to infection
3. Expression from cloned cDNA of cell-surface secreted forms of the glycoprotein of vesicular stomatitis virus in eucaryotic cells
4. The entry into host cells of Sindbis virus, vesicular stomatitis virus, and Sendai virus
5. A cell line expressing vesicular stomatitis virus glycoprotein fuses at low pH
6. Cell surface expression of fusogenic vesicular stomatitis virus G protein from cloned cDNA
7. Cell fusion by semiliki forest, influenza, and vesicular stomatitis virus
8. pH-dependent fusion of vesicular stomatitis virus with Vero cells
9. Vesicular stomatitis virus glycoprotein mutations that affect membrane fusion activity and abolish virus infectivity
10. Characterization of the putative fusogenic domain in Vesicular Stomatitis Virus Glycoprotein G
11. Mutations at two conserved acidic amino acids in the glycoprotein of vesicular stomatitis virus affect pH-dependent conformational changes and reduce the pH threshold for membrane fusion
12. Effect of vesicular stomatitis viurs matrix protein on transcription directed by host RNA polymerases I, II, and III
13. Cell surface expression of fusogenic vesicular stomatitis virus G protein from cloned cDNA
14. Influence of new glycosylation sites on expression of the vesicular stomatitis virus G protein at the plasma membrane
15. Isolation of stable mouse cell lines that express cell surface and secreted forms of the vesicular stomatitis virus glycoprotein
16. The search for the "best" cytokine to induce antitumor immunity
17. Intratracheal administration of IL-12 plasmid-cationic lipid complexes inhibits murine lung metastases
18. Polyvinyl derivatives as novel interactive polymers controlled gene delivery to muscle
19. Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia nad hyperglycemia
20. Delivery of molecular and cellular medicine to solid tumors
21. Oxygenation in tumors by modified hemoglobins
22. Mechanism of interleukin-12-mediated toxicities during experimental viral infections: Role of tumor necrosis factor and glucocorticoids
23. Cancer trial of interleukin-12 halted
24. Construction and characterization of retroviral vectors expressing biologically active human interleukin-12
25. High cytokine production and effective antitumor activity of a recombinant vaccinia virus encoding murine interleukin-12
26. Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle