Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2

Molecular Human Reproduction

Volumn 7, Issue 2, 2001, Pages 185-194

  Clark, David A ^a   Ding, Jin Wen ^b   Yu, Gary ^b   Levy, Gary A ^b   Gorczynski, Reginald M ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Abortion; Fgl2 prothrombinase; Mouse embryo; OX 2

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN; GLYCOPROTEIN OX 2; INTERLEUKIN 1; THROMBIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DECIDUA; FEMALE; FETOPLACENTAL UNIT; FIBRIN DEPOSITION; IMMUNOLOGICAL TOLERANCE; LEUKOCYTE ACTIVATION; NIDATION; NONHUMAN; PREGNANCY TERMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPONTANEOUS ABORTION; TROPHOBLAST;

ANIMALIA;

EID: 0035122381     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/7.2.185     Document Type: Article

References (49)

1. + T cells as a basis for stress-triggered substance P-mediated abortion in mice
2. Murine T cell determination of pregnancy outcome. I. Effects of strain, αβ T cell receptor, γδ T cell receptor, and γδ T cell subsets
3. Soluble receptors neutralizing TNF-α and IL-1 block stress-triggered murine abortion
4. + T cells influence success and failure of pregnancy in CBA/J×XDBA/2 matings
5. Decidual infiltration and activation of macrophages leads to early embryo loss
6. Characterization and localization of Mox2, the gene encoding the murine homolog of MRC OX-2 membrane glycoprotein
7. Association of some cell surface antigens of lymphoid cells and surface differentiation antigens with early rat pregnancy
8. Maternal T cell reactivity in pregnancy
9. Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy
10. Decidual natural killer cytotoxicity is decreased in normal pregnancy but not in anembryonic pregnancy and recurrent spontaneous abortion
11. Cloning and characterization of the murine homolog of the rat/human MRC OX-2 gene
12. Hard science versus phenomenology in reproductive immunology
13. T cells in pregnancy: Illusion and reality
14. + lymphoid cells in human first trimester pregnancy decidua as a source of novel TGF-β2-related immunosuppressive factors
15. + T-cell-dependent suppression of natural effector cell cytotoxicity against trophoblast target cells
16. The cutting edge: Cytokine-dependent abortion in CBA×DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase
17. Why did your mother reject you? Immunogenetic determinants of the response to environmental selective pressure expressed at the uterine level
18. The emerging role of immunoregulation of fibrinogen-related procoagulant fgl2 in the success or spontaneous abortion of early pregnancy in mice and humans
19. FGL2 in pregnancy: A novel prothrombinase at the fetomaternal interface may prevent bleeding and cause abortions
20. Immunotherapy for recurrent pregnancy loss: Analysis of results from clinical trials
21. Hemostatic and metabolic abnormalities in women with unexplained recurrent abortion
22. Embryo loss, blastomere development and chromosome constitution after human chorionic gonadotropin-induced ovulation in mice and rats with regular cycles
23. Fulminant hepatic failure in murine hepatitis virus strain 3 infection: Tissue-specific expression of a novel fgl2 prothrombinase
24. + hybridomas derived from mice given portal vein donor-specific preimmunization and skin allografts
25. Increased expression of the novel molecule OX-2 is involved in prolongation of murine renal allograft survival
26. An immunoadhesion incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival
27. Evidence that an OX-2-positive cell can inhibit stimulation of type 1 cytokine production by bone marrow-derived B7-1 (and B 7.2)-positive dendritic cells
28. Receptor engagement on cells expressing a ligand for the tolerance-inducing molecule OX2 induces an immunoregulatory population which inhibits alloreactivity in vitro and in vivo
29. Environmental influences on immunologically associated spontaneous abortions in CBA/J mice
30. Cardioprotective effect of interleukin-10 in murine myocardial ischemia-reperfusion
31. Activation of the first component of complement, C1: Comparison of the effect of sixteen different enzymes on serum C1
32. Immune coagulation in preeclampsia
33. Anchoring villi in human placental basal plate: Lymphocytes, macrophages, and coagulation
34. Endometrial, T, B, and NK cells in patients with recurrent abortion: Altered profile and pregnancy outcome
35. The role of T-helper cytokines in human reproduction
36. Release of a TGF-β2-related suppressor factor from postimplantation murine decidual tissue can be correlated with the detection of a subpopulation of cells containing RNA for TGF-β2
37. A subset of patients with recurrent spontaneous abortion is deficient in transforming growth factor β2 producing 'suppressor cells' in uterine tissue near the placental attachment site
38. T cells of human early pregnancy decidua. Evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation
39. Is spontaneous resorption in the DBA/2-mated CBA/J mouse due a defect in 'seed' or in 'soil'?
40. TGF-β and endothelium during immune injury
41. Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX-2
42. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10
43. Placental and decidual histology in spontaneous abortion: Detailed description and correlations with chromosome number
44. Frequency of abnormal karyotypes among abortuses from women with and without a history of recurrent spontaneous abortion
45. + lymphocytes on killing of natural killer- and lymphokine-activated killer-sensitive targets
46. A critical role for murine complement receptor crry in fetomaternal tolerance
47. Decidual natural killer cells in recurrent spontaneous abortion with normal chromosome content
48. + T cells in decidual and peripheral lymphocytes of normal pregnancy and spontaneous abortion with and without a history of recurrent abortion
49. Activated protein C resistance and factor V leiden mutation can be associated with first- as well as second-trimester recurrent pregnancy loss