Decidual infiltration and activation of macrophages leads to early embryo loss

American Journal of Reproductive Immunology

Volumn 37, Issue 6, 1997, Pages 471-477

  Baines, M G ^a   Duclos, A J ^a   Antecka, E ^a   Haddad, E K ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Abortion; Cytokines; Macrophage; Mouse; Pregnancy

Indexed keywords

CYTOKINE; CYTOTOXIN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE;

ANIMAL TISSUE; CONFERENCE PAPER; DECIDUA; EMBRYO; EMBRYO RESORPTION; FETUS WASTAGE; FIRST TRIMESTER PREGNANCY; INFLAMMATORY CELL; MACROPHAGE ACTIVATION; MOUSE; NATURAL KILLER CELL; NIDATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0030948919     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0897.1997.tb00262.x     Document Type: Conference Paper

References (27)

1. Baines MG, Gendron RL. Natural and experimental animal models of reproductive failure. In Immunology of Pregnancy, Chaouat G (ed). Boca Raton, CRC Press, Inc., 1993, pp 173-203.
2. Clark DA, Chaput A, Tutton D. Active suppression of host-vs-graft reaction in pregnant mice: VII. Spontaneous abortion of allogeneic CBA/j x DBA/2 fetuses in the uterus of CBA/j mice correlates with deficient non-T suppressor cell activity. J Immunol 1986; 136:1668-1675.
3. Clark DA, McDermott MR, Szewczuk MR. Impairment of host-versus-graft reaction in pregnant mice. II. Selective suppression of cytotoxic T-cell generation correlates with soluble suppressor activity and with successful allogeneic pregnancy. Cell Immunol 1980; 52:106-118.
4. Baines MG, Billingsley KA, de Fougerolles AR, Duclos AJ, Olney HJ, Pomerantz DK, Gendron RL. Evaluation of the role of exogenous pathogens on the incidence of embryo loss during early pregnancy in mice. J Reprod Immunol 1994; 26:17-30.
5. Lin H, Mosmann TR, Guilbert LJ, Tuntipopipat S, Wegmann TG. Synthesis of T helper 2-type cytokines at the maternalfetal interface. J Immunol 1993; 151:4562-4573.
6. Clark DA, Chaouat G, Mogil R, Wegmann TG. Prevention of spontaneous abortion in DBA/2-mated CBA/J mice by GM-CSF involves CD8+ T cell-dependent suppression of natural effector cell cytotoxicity against trophoblast target cells. Cell Immunol 1994; 154:143-152.
7. Chaouat G, Assal Meliani A, Martal J, Raghupathy R, Elliot J, Mosmann TR, Wegmann TG. IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect In IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol 1995; 154:4261-4268.
8. Muzikova E, Clark DA. Is spontaneous resorption in the DBA/2-mated CBA/J mouse due to a defect in "seed" or in "soil"? Am J Reprod Immunol 1995; 33:81-85.
9. Clark DA, Banwatt DK, Manuel J, Fulop G, Croy BA. SCID mice in reproductive biology. Curr Top Microbiol Immunol 1989; 152:227-233.
10. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-2357.
11. Gendron RL, Baines MG. Infiltrating decidual natural killer cells are associated with spontaneous abortion in mice. Cell Immunol 1988; 113:261-267.
12. Gendron RL, Nestel FP, Lapp WS, Baines MG. Lipopolysaccharide-induced fetal resorption in mice is associated with the intrauterine production of tumour necrosis factor-alpha. J Reprod Fertil 1990; 90:395-402.
13. Duclos AJ, Haddad EK, Baines MG. Presence of activated macrophages in a murine model of early embryo loss. Am J Reprod Immunol 1995; 33:354-366.
14. Haddad EK, Duclos AJ, Baines MG. Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells. J Exp Med 1995; 182:1143-1151.
15. Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta 1994; 15:819-835.
16. Tangri S, Wegmann TG, Lin H, Raghupathy R. Maternal anti-placental reactivity in natural, immunologically-mediated fetal resorptions. J Immunol 1994; 152:4903-4911.
17. Duclos AJ, Pomerantz DK, Baines MG. Relationship between decidual leukocyte infiltration and spontaneous abortion in a murine model of early fetal resorption. Cell Immunol 1994; 159:184-193.
18. Duclos AJ, Haddad EK, Chalifour LE, Baines MG. Embryo infiltration by maternal macrophages is associated with selective expression of proto-oncogenes in a murine model of spontaneous abortion. Biol Reprod 1996; 54:1088-1095.
19. Chalifour LE, Fahmy R, Holder EL, Hutchinson EW, Osterland CK, Schipper HM, Wang E. A method for analysis of gene expression patterns. Anal Biochem 1994; 216:299-304.
20. Gendron RL, Farookhi R, Baines MG. Resorption of CBA/J x DBA/2 mouse conceptuses in CBA/J uteri correlates with failure of the feto-placental unit to suppress natural killer cell activity. J Reprod Fertil 1990; 89:277-284.
21. Pross HF, Baines MG, Rubin P, Shragge P, Patterson M. Spontaneous human lymphocyte-mediated cytotoxicity against tumour target cells. IX. Quantitation of natural killer cell activity. J Clin Immunol. 1981; 1:51-63.
22. Wegmann TG, Lin H, Guilbert LJ, Mosmann TR, Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? [see comments]. [Review]. Immunol Today 1993; 14:353-356.
23. Ortaldo JR. Cytokine Production by CD3-Large Granular Lymphocytes. In Reynolds C, Wiltrout R (eds). Functions of the Natural Immune System. New York: Plenum Press, 1989:299-321.
24. Mond JJ, Brunswick M. A role for IFN-gamma and NK cells in immune responses to T cell-regulated antigens types 1 and 2. Immunol Rev 1987; 99:105-118.
25. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988; 141:2407-2412.
26. de Fougerolles AR, Baines MG. Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate. J Reprod Immunol 1987; 11:147-153.
27. Baines MG, Duclos AJ, de Fougerolles AR, Gendron RL. Immunological prevention of spontaneous early embryo resorption is mediated by non-specific immunostimulation. Am J Reprod Immunol 1996; 35:34-42.