Regulation of the IL-10 production by human T cells

Scandinavian Journal of Immunology

Volumn 53, Issue 2, 2001, Pages 139-147

  Rafiq, K ^a,b   Charitidou, L ^a,b   Bullens, D M A ^a,b   Kasran, A ^a,b   Lorre K ^a,b   Ceuppens, J L ^a,b   Van Gool, S W ^a,b,c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b INNOGENETICS   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON RECEPTOR; B7 ANTIGEN; CALCINEURIN; CALCIUM; CD28 ANTIGEN; CYTOKINE RECEPTOR; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MONOCLONAL ANTIBODY; PROSTAGLANDIN E2; REAGENT;

ADULT; ANTIBODY RESPONSE; ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INHIBITION KINETICS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD45; ANTIGENS, CD58; ANTIGENS, CD80; CALCINEURIN; CALCIUM SIGNALING; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOSPORINE; DINOPROSTONE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE I, RECOMBINANT; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; IONOMYCIN; IONOPHORES; LYMPHOCYTE ACTIVATION; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN KINASE C; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTORS;

EID: 0035121969     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2001.00851.x     Document Type: Article

References (66)

1. Interleukin-10
2. Structural and biological stability of the human interleukin 10 homodimer
3. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
4. Expression cloning and characterization of a human IL-10 receptor
5. Identification and functional characterization of a second chain of the interleukin-10 receptor complex
6. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
7. Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster
8. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
9. Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype
10. Differential expression and modulation of costimulatory molecules CD80 and CD86 on monocytes from patients with systemic lupus erythematosus
11. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells
12. Split activity of interleukin-10 on antigen capture and antigen presentation by human dendritic cells: Definition of a maturative step
13. In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation
14. Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: Effects of flora and proinflammatory cytokines
15. Protective role of interleukin-10 in atherosclerosis
16. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
17. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats
18. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees
19. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation
20. IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells
21. High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane
22. Autocrine and paracrine regulation of human T cell IL-10 production
23. Cyclosporin-A increases interferon-gamma production by T cells when costimulated through CD28
24. Differences in regulatory pathways identify subgroups of T cell-derived Th2 cytokines
25. A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit
26. Human T cell activation with PHA. The function of IL-6 as an accessory signal
27. More exact quantification of interleukin-2 production by addition of anti-Tac monoclonal antibody to cultures of stimulated lymphocytes
28. Helper-independent activation of human CD8 (+) cells: The role of CD28 costimulation
29. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
30. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
31. CD28 ligation by mAb or B7/BB1 provides an accessory signal for the CsA-resistant generation of cytotoxic T cell activity
32. Accessory signalling by B7-1 for T cell activation induced by anti-CD2: Evidence for IL-2-independent CTL generation and CsA-resistant cytokine production
33. Cyclic AMP second messenger systems
34. Modulation of inflammation and immunity by cyclic AMP
35. Studies on the cyclic AMP reponse to prostaglandin in human lymphocytes
36. Role of IL-10 in the crossregulation of prostaglandins and cytokines in monocytes
37. A cascade of cytokines is responsible for IL-9 expression in human T cells. Involvement IL-2, IL-4 and IL-10
38. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement
39. Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T cells
40. Interferon-α upregulates both interleukin-10 and interferon-γ production by human CD4+ T cells
41. Interleukin 12 and B7/CD28 interaction synergistically upregulate interleukin 10 production by human T cells
42. Signal transduction in T cells
43. Signal transduction in T lymphocytes
44. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and
45. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
46. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
47. Expression of NFAT family proteins in normal human T cells
48. Cutting edge: Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: Requirement for CD28 up-regulation of RE/AP
49. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
50. Transcription factors of the NFAT family: Regulation and function
51. Effect of pharmacological agents on the productions of interleukin-10 by the murine D10.G4.1 TH2 cell line in vitro
52. In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: Differential modulation by cyclosporin A
53. Circulating levels of interleukin 10 and other cytokines in rheumatoid arthritis treated with cyclosporin A or combination therapy
54. Quantitative comparison of rapamycin and cyclosporine effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction
55. CD28/CTLA-4 and CD80/CD86 families - Signaling and function
56. Activation of the interleukin-10 gene in the human T lymphoma line HuT 78: Identification and characterization of NF-kappa B binding sites in the regulatory region of the interleukin- 10 gene
57. Activation of the p38 mitogen-activated protein kinase by type I interferons
58. CD28 ligation in T-cell activation: Evidence for two signal transduction pathways
59. Adhesion receptors of the immune system
60. Regulation of the immune response by prostaglandins
61. MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes
62. Prostaglandin E2 inhibits human T-cell proliferation after crosslinking of the CD3-Ti complex by directly affecting T cells at an early step of the activation process
63. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes
64. Differential regulation of IFN-γ, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway
65. Prostaglandin E2 selectively inhibits human CD4+ T cells secreting low amounts of both IL-2 and IL-4
66. An unexpected increase in circulating IFN-gamma by cyclosporin A in atopic patients: A discrepancy between in vitro and in vivo events