Activation of the interleukin-10 gene in the human T lymphoma line HuT 78: Identification and characterization of NF-κ B binding sites in the regulatory region of the interleukin-10 gene

European Journal of Haematology

Volumn 59, Issue 3, 1997, Pages 162-170

  Mori, Naoki ^a,b   Prager, Diane ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

IL 10; NF B; T cell lymphoma

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MONOCLONAL ANTIBODY; PHOSPHOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CLINICAL PROTOCOL; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; LYMPHOMA CELL LINE; MACROPHAGE; PRIORITY JOURNAL; REGULATOR GENE; SEZARY CELL; T CELL LYMPHOMA;

EID: 0030880984     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1997.tb00970.x     Document Type: Article

References (42)

1. VIEIRA P, DE WAAL-MALEFYT R, DAND M-N, et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci USA 1991: 88: 1172-1176.
2. DE WAAL MALEFYT R, ABRAMS J, BENNETT B, FIGDOR CG, DE VRIES JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991: 174: 1209-1220.
3. + T cell clones and peripheral blood T cells. J Immunol 1992: 149: 2378-2384.
4. FIORENTINO DF, ZLOTNIK A, MOSMANN TR, HOWARD M, O'GARRA A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991: 147: 3815-3822.
5. BOGDAN C, VODOVOTZ Y, NATHAN C. Macrophage deactivation by interleukin 10. J Exp Med 1991: 174: 1549-1555.
6. DE WAAL MALEFEYT R, YSSEL H, RONCAROLO M-G, SPITS H, DE VRIES JE. Interleukin-10. Curr Opin Immunol 1992: 4: 314-320.
7. RALPH P, NAKOINZ I, SAMPSON-JOHANNES A, et al. IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J Immunol 1992: 148: 808-814.
8. TE VELDE AA, DE WAAL MALEFYT R, HUIJBENS RJF, DE VRIES JE, FIGDOR CG. IL-10 stimulates monocyte Fc γ R surface expression and cytotoxic activity: distinct regulation of antibody-dependent cellular cytotoxicity by IFN-γ, IL-4, and IL-10. J Immunol 1992: 149: 4048-4052.
9. FIORENTINO DF, BOND MW, MOSMANN TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989: 170: 2081-2095.
10. Go NF, CASTLE BE, BARRETT R, et al. Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 1990: 172: 1625-1631.
11. THOMPSON-SNIPES L, DHAR V, BOND MW, MOSMANN TR, MOORE KW, RENNICK DM. Interleukin 10: a novel stimulatory factor for mast cells and their progenitors. J Exp Med 1991: 173: 507-510.
12. FIORENTINO DF, ZLOTNIK A, VIEIRA P, et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991: 146: 3444-3451.
13. ROUSSET F, GARCIA E, DEFRANCE T, et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992: 89: 1890-1893.
14. + T cell clones and resting T cells: specific inhibition of IL-2 production and proliferation. J Immunol 1993: 150: 4754-4765.
15. FINKE J, TERNES P, LANGE W, MERTELSMANN R, DOLKEN G. Expression of interleukin 10 in B lymphocytes of different origin. Leukemia 1993: 7: 1852-1857.
16. BENJAMIN D, KNOBLOCH TJ, DAYTON MA. Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10. Blood 1992: 80: 1289-1298.
17. EMILIE D, TOUITOU R, RAPHAEL M, et al. In vivo production of interleukin-10 by malignant cells in AIDS lymphomas. Eur J Immunol 1992: 22: 2937-2942.
18. LU ZY, ZHANG XG, RODRIGUEZ C, et al. Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells. Blood 1995: 85: 2521-2527.
19. MERVILLE P, ROUSSET F, BANCHEREAU J, KLEIN B, BATAILLE R. Serum interleukin 10 in early stage multiple myeloma. Lancet 1992: 340: 1544-1545.
20. BLAY J-Y, BURDIN N, ROUSSET F, et al. Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor. Blood 1993: 82: 2169-2174.
21. CORTES JE, TALPAZ M, CABANILLAS F, SEYMOUR JF, KURZROCK R. Serum levels of interleukin-10 in patients with diffuse large cell lymphoma: lack of correlation with prognosis. Blood 1995: 85: 2516-2520.
22. O'GARRA A, CHANG R, GO N, HASTINGS R, HAUGHTON G, HOWARD M. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol 1992: 22: 711-717.
23. KUBE D, PLATZER C, VON KNETHEN A, et al. Isolation of the human interleukin 10 promoter: characterization of the promoter activity in Burkitt's lymphoma cell lines. Cytokine 1995: 7: 1-7.
24. PLATZER C, MEISEL C, VOGT K, PLATZER M, VOLK H-D. Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int Immunol 1995: 7: 517-523.
25. PRAGER D, GERBREMEDHIN S, MELMED S. An insulin-induced DNA-binding protein for the human growth hormone gene. J Clin Invest 1990: 85: 1680-1685.
26. O'CONNELL MA, CLEERE R, LONG A, O'NEILL LAJ, KELLEHER D. Cellular proliferation and activation of NF κ B are induced by autocrine production of tumor necrosis factor α in the human T lymphoma line HuT 78. J Biol Chem 1995: 270: 7399-7404.
27. MOLITOR JA, WALKER WH, DOERRE S, BALLARD DW, GREENE WC. NF-κ B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci USA 1990: 87: 10028-10032.
28. BAEUERLE PA. The inducible transcription activator NF-κ B: regulation by distinct protein subunits. Biochim Biophys Acta 1991: 1072: 63-80.
29. ARIMA N, KUZIEL WA, GRDINA TA, GREENE WC. IL-2-induced signal transduction involves the activation of nuclear NF-κ B expression. J Immunol 1992: 149: 83-91.
30. BROWNELL E, MITTEREDER N, RICE NR. A human rel protooncogene cDNA containing an Alu fragment as a potential coding exon. Oncogene 1989: 4: 935-942.
31. BOURS V, BURD PR, BROWN K, et al. A novel mitogen-inducible gene product related to p50/p105-NF-κ B participates in transactivation through a κ B site. Mol Cell Biol 1992: 12: 685-695.
32. RYSECK R-P, BULL P, TAKAMIYA M, et al. RelB, a new Rel family transcription activator that can interact with p50-NF-κ B. Mol Cell Biol 1992: 12: 674-684.
33. HANSEN SK, NERLOV C, ZABEL U, et al. A novel complex between the p65 subunit of NF-κ B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. EMBO J 1992: 11: 205-213.
34. KUNSCH C, RUBEN SM, ROSEN CA. Selection of optimal κ B/Rel DNA-binding motifs: interaction of both subunits of NF-κ B with DNA is required for transcriptional activation. Mol Cell Biol 1992: 12: 4412-4421.
35. BAEUERLE PA, BALTIMORE D. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κ B transcription factor. Cell 1988: 53: 211-217.
36. BEG A A, FINCO TS, NANTERMET PV, BALDWIN JR AS. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I κ B α: a mechanism for NF-κ B activation. Mol Cell Biol 1993: 13: 3301-3310.
37. HANKEL T, MACHLEIDT T, ALKALAY I, KRONKE M, BEN-NERIAH Y, BAEUERLE PA. Rapid proteolysis of I κ B-α is necessary for activation of transcription factor NF-κ B. Nature 1993: 365: 182-185.
38. HEMAR A, CEREGHINI S, CORNET V, et al. κ B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line. J Immunol 1991: 146: 2409-2416.
39. BEISSERT S, HOSOI J, GRABBE S, ASAHINA A, GRANSTEIN RD. IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells. J Immunol 1995: 154: 1280-1286.
40. BALDWIN JR AS. The NF-κ B and I κ B proteins: new discoveries and insights. Annu Rev Immunol 1996: 14: 649-681.
41. DUYAO MP, BUCKLER AJ, SONENSHEIN GE. Interaction of an NF-κ B-like factor with a site upstream of the c-myc promoter. Proc Natl Acad Sci USA 1990: 87: 4727-4731.
42. KITAJIMA I, SHINOHARA T, BILAKOVICS J, BROWN DA, XU X, NERENBERG M. Ablation of transplanted HTLV - I Tax-transformed tumors in mice by antisense inhibition of NF-κ B. Science 1992: 258: 1792-1795.