Mechanisms of carcinogenesis and the mutant mouse

Current Opinion in Genetics and Development

Volumn 6, Issue 1, 1996, Pages 65-70

  Williams, Bart O ^a   Jacks, Tyler ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMAL MODEL; APOPTOSIS; CANCER GENETICS; CANCER MODEL; CARCINOGENESIS; COLORECTAL CANCER; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; STEM CELL; TUMOR SUPPRESSOR GENE;

ANIMALIA; MURINAE;

EID: 0030060095     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)90012-X     Document Type: Article

References (10)

1. Knudson AG: Antioncogenes and human cancer. Proc Natl Acad Sci USA 1993, 90:10914-10921.
2. Lowe SW, Schmitt ES, Smith SW, Osborne BA, Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993, 362:847-849.
3. Lowe SW, Ruley HE, Jacks T, Housman DE: p53-dependent apoptosis modulates the cytoxicity of anticancer agents. Cell 1993, 74:957-967.
4. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH: Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993, 362:849-852.
5. Vogel KS, Brannan CI, Jenkins NA, Copeland NG, Parada LF: Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell 1995, 82:733-742.
6. This work utilizes neuronal cells derived from Nf-1-deficient embryos and shows that they are less dependent on survival factors than wild-type cells.
7. Su L-K, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA, Dove WF: Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992, 256:668-670.
8. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992, 356:215-221.
9. Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A, Donehower LA: Spontaneous and carcinogen-induced tumors in p53-deficient mice. Nature Genet 1993, 5:225-229.
10. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA: Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994, 4:1-7.