Catechol-O-methyltransferase decreases levodopa toxicity in vitro

Clinical Neuropharmacology

Volumn 24, Issue 1, 2001, Pages 27-30

  Offen, D ^a   Panet, H ^a   Galili Mosberg, R ^a   Melamed, E ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

3 O methyldopa; Catechol O methyltransferase; Levodopa; Parkinson's disease; Tolcapone

Indexed keywords

CATECHOL METHYLTRANSFERASE; LEVODOPA; TOLCAPONE;

ANIMAL CELL; ARTICLE; AUTOOXIDATION; CONTROLLED STUDY; GRANULE CELL; METHYLATION; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIPARKINSON AGENTS; CATECHOL O-METHYLTRANSFERASE; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; LEVODOPA; MICE; NEURONS; PC12 CELLS; RATS; TYROSINE;

EID: 0035116859     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-200101000-00006     Document Type: Article

References (22)

1. L-dopa cytotoxicity to PC-12 cells in culture is via its auto-oxidation
2. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA: Implications for the treatment of Parkinson's disease
3. Levodopa induces apoptosis in cultured neuronal cells: A possible accelerator of nigrostriatal degeneration in Parkinson's disease?
4. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
5. Dopamine-melanin induces apoptosis in PC12 cells: Possible implications for the etiology of Parkinson's disease
6. Dopa and dopamine cause cultured neuronal death in the presence of iron
7. Intense oxidative DNA damage promoted by L-dopa and its metabolites: Implications for neurodegenerative disease
8. Is levodopa toxic?
9. Long-term administration of L-dopa does not damage dopaminergic neurons in the mouse
10. Preservation of the substantia nigra and locus ceruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period
11. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
12. Suppressive effect of L-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine
13. Differential effects of chronic L-dopa treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydroxydopamine
14. Chronic levodopa impairs morphological development of graft embryonic dopamine neurons
15. Extending levodopa action: COMT inhibition
16. COMT inhibition in the treatment of Parkinson's disease
17. 3-O-methyldopa administration does not alter fluorodopa transport into the brain
18. Tolcapone: A selective catechol-O-methyltransferase inhibitor for treatment of Parkinson's disease
19. Levodopa toxicity and apoptosis
20. The mechanism of perturbation in monoamine metabolism by L-dopa therapy: In vivo and in vitro studies
21. Glia conditioned medium protects fetal rat midbrain neurons in culture from L-dopa toxicity
22. Enzyme activities of monoamine oxidase, catechol-O-methyltransferase and gamma-aminobutyric acid transaminase in primary astroglial cultures and adult rat brain from different brain regions