Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex

Infection and Immunity

Volumn 69, Issue 3, 2001, Pages 1739-1746

  Linder, S ^a   Heimerl, C ^a   Fingerle, V ^a   Aepfelbacher, M ^a   Wilske, B ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; RAC1 PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ARTICLE; BORRELIA BURGDORFERI; COMPLEX FORMATION; CONTROLLED STUDY; HOST CELL; HUMAN; HUMAN CELL; LYME DISEASE; MACROPHAGE FUNCTION; NONHUMAN; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN POLYMERIZATION; SIGNAL TRANSDUCTION; SPIROCHETE;

EID: 0035115283     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.3.1739-1746.2001     Document Type: Article

References (46)

1. Mechanisms of phagocytosis in macrophages
2. Rho is a negative regulator of human monocyte spreading
3. Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42
4. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
5. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
6. Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody
7. Interactions of phagocytes with the Lyme disease spirochete: Role of the Fc receptor
8. Lyme disease - A tick-borne spirochetosis?
9. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
10. Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers
11. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukosytes
12. Clustering of fibronectin adhesins toward Treponema denticola tips upon contact with immobilized fibronectin
13. Differential expression of outer surface proteins A and C by individual Borrelia burgdorferi in different genospecies
14. Infectivity of Borrelia burgdorferi correlates with resistance to elimination by phagocytic cells
15. The ecology of Lyme borreliosis in Europe
16. Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ, receptors in macrophages
17. Interpretation criteria for standardized Western blots for three European species of Borrelia burgdorferi sensu lato
18. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins
19. Phagocytosis of the legionnaires' diseases bacterium (Legionella pneumophila) occurs by a novel mechanism: Engulfment within a pseudopod coil
20. Phosphohexosyl recognition is a general characteristic of pinocytosis of lysosomal glycosidases by human fibroblasts
21. Binding of human plasminogen and urokinase-type plasminogen activator to the Lyme disease spirochete. Borrelia burgdorferi
22. Direct interaction of the Wiskolt-Aldrich syndrome protein with the GTPase Cdc42
23. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
24. The polarization defect of Wiskott-Aldrich syndrome macrophages is linked to dislocalization of the Arp2/3 complex
25. Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
26. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
27. Fc receptor-mediated phagocytosis requires CDC42 and Rac1
28. Involment of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3
29. Controlling the maturation of pathogen-containing vacuoles: A matter of life and death
30. Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes
31. The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages
32. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into sytoskeletal structures
33. Lyme borreliosis: Basic science and clinical aspects
34. European Borrelia burgdorferi isolated from humans and ticks: Culture conditions and antibiotic susceptibility
35. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
36. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
37. Coiling phagocytosis discriminates between different spirochetes and is enhanced by phorbol myristate acetate and granulocyte-macrophage colony-stimulating factor
38. Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi
39. Phagocytosis of microorganisms by means of overshooting pseudopods: Where do we stand?
40. Medical progress - Lyme disease
41. Studies of the expression of the Wiskott-Aldrich syndrom protein
42. Tube phagocytosis, a novel way for neutrophils to phagocytize Borrelia burgdorferi
43. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is inplicated in actin polymerization
44. Recombinant immunoblot in the serodiagnosis of Lyme borreliosis
45. An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis
46. Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi