New mutation in ParE in a pneumococcal in vitro mutant resistant to fluoroquinolones

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 3, 2001, Pages 952-955

  Janoir, C ^a   Varon, E ^a   Kitzis, M D ^a   Gutmann, L ^a  

^a SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE; GREPAFLOXACIN; MOXIFLOXACIN; NOVOBIOCIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; ENZYME SUBUNIT; GENE MUTATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; BINDING SITES; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG RESISTANCE, MICROBIAL; FLUOROQUINOLONES; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PNEUMOCOCCAL INFECTIONS; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOCOCCUS PNEUMONIAE;

EID: 0035114559     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.3.952-955.2001     Document Type: Article

References (31)

1. The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyses ATP and binds coumarin drugs
2. Engineering the specificity of antibacterial fluoroquinolones: Benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase
3. Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae
4. Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae
5. Structure and mechanism of DNA topoisomerase II
6. In vivo selection of Streptococcus pneumoniae, resistant to quinolones, including sparfloxacin
7. Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae
8. Dimerization of Escherichia coil DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center
9. gvrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by' Escherichia coli DNA gyrase
10. In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae
11. DNA gyrase, topoisomerase IV, and the 4-quinolones
12. Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
13. Cloning and primary structure of Staphylococcus aurcus DNA topoisomerase IV: A primary target of fluoroquinolones
14. Effects of mutations in Gr1A of topoisomerase IV from Staphylococcus aureus on quinolone and coumarin activity
15. High-level fluoroquinolone-resistance in Streptococcus pneumoniae requires mutations in parC and gvr4
16. Prevalence of gvr4, gvrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season
17. Activities of newer fluoroquinolones against Streptococcus pneumoniae clinical isolates including those with mutations in the gvrA, parC, and parE loci
18. Crystal structure of the breakage-reunion domain of DNA gyrase
19. ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype
20. Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance
21. Cloning and characterization of the parC and pare genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: Role in fluoroquinolone resistance
22. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae
23. Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: Selective targeting of gyrase or topoisomerase IV by quinolones
24. Characterization of a mutation in the pare gene that confers fluoroquinolone resistance in Streptococcus pneumoniae
25. Characterization of the ATP binding site on Escherichia coli DNA gyrase
26. Contribution of mutations in gvrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro
27. ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae
28. Crystal structure of an N-terminal fragment of the DNA gyrase B protein
29. A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex
30. Quinolone resistance-determining region in the DNA gyrase gvrA gene of Escherichia coli
31. Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae