Induction of apoptosis in human lymphocytes by the herbicide 2,4-dichlorophenoxyacetic acid

Human Immunology

Volumn 62, Issue 1, 2001, Pages 64-74

  Kaioumova, Dinara ^a   Süsal, Caner ^a   Opelz, Gerhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

2,4 dichlorophenoxyacetic acid; Apoptosis; Bcl 2; Caspases; Human lymphocytes

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; AMMONIUM DERIVATIVE; AROMATIC HYDROCARBON RECEPTOR; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; DIMETHYLAMMONIUM; FAS ANTIGEN; HERBICIDE; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; T LYMPHOCYTE;

2,4-DICHLOROPHENOXYACETIC ACID; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD95; APOPTOSIS; BENZOFLAVONES; CASPASES; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; HERBICIDES; HUMANS; JURKAT CELLS; LYMPHOCYTES; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; TRANSFECTION;

EID: 0035113194     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(00)00229-9     Document Type: Article

References (43)

1. Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base
2. Evaluation of herbicides for possible mutagenic properties
3. The influence of pH on the effects of 2,4-D (2,4-dichlorophenoxyacetic acid, Na salt) on Saccharomyces cerevisiae and Salmonella typhimurium
4. Phenoxy herbicides and cancer: Insufficient epidemiologic evidence for a causal relationship
5. Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: A study in isolated hepatocytes
6. 2,4-D induced clastogenicity and elevated rates of sister chromatid exchanges in cultured human lymphocytes
7. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
8. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apol, and DR 3 and is lethal prenatally
9. Death ligand/receptor-independent caspase activation mediates drug-induced cytotoxic cell death in human malignant glioma cells
10. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
11. Caspases: The proteases of the apoptotic pathway
12. Mitochondrial control of apoptosis
13. Two CD95 (APO-1/Fas) signaling pathways
14. Loss of function of cytochrome c in Jurkat cells undergoing Fas-mediated apoptosis
15. Bcl-2 and the outer mitochondrial membrane in the inactivation of cytocrome c during Fas-mediated apoptosis
16. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
17. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
18. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
19. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
20. Mitochondrial control of nuclear apoptosis
21. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors
22. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
23. α-naphthoflavone acts as an antagonist of 2,3,7,8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor
24. The mechanisms of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP/A/ gene expression
25. Elevated dioxin blood levels in russian chemical workers and their children following maternal exposure
26. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
27. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
28. The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
29. Bcl-2 blocks loss of motochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors
30. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
31. Caspases: Killer proteases
32. Effects of phenoxyacetic acids on the induction of chromosome aberrations in vitro and in vivo
33. Comparison of the cytotoxicity and DNA-damaging properties of 2,4-D and U 46 D Fluid (dimethylammonium salt of 2,4-D)
34. Suitability of different cytotoxicity assays for screening combination effects of environmental chemicais in human fibroblasts
35. Toxic effects of the herbicide 2,4-dichlorophenoxyacetic acid on lymphoid organs of the rat
36. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins
37. Immunologic disoders of the acute dioxin exposed patient
38. Mechanism of TCDD-mediated apoptosis in human T-lymphoblastic cell lines
39. Bcl-2 protects macrophages from nitric oxide-induced apoptosis
40. ICE family proteases: Mediators of all apoptotic cell death?