Unraveling the mechanisms by which heat shock proteins activate the immune system

Current Opinion in Molecular Therapeutics

Volumn 3, Issue 1, 2001, Pages 25-30

  Palliser, D ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

CTL elicitation; Heat shock protein; Innate immunity; MHC I processing; Receptor

Indexed keywords

ADJUVANT; CD8 ANTIGEN; HEAT SHOCK PROTEIN; HYBRID PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; DOCUMENTATION; ENDOSOME; IMMUNE RESPONSE; IMMUNE SYSTEM; INTERNALIZATION; MOUSE; NONHUMAN; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD14; CYTOKINES; DROSOPHILA PROTEINS; HEAT-SHOCK PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INFLAMMATION; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES, CYTOTOXIC; TOLL-LIKE RECEPTORS;

ANIMALIA;

EID: 0035113012     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
2. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90 and hsp70
3. Tumor rejection antigen gp96/grp94 is an ATPase: Implications for protein folding and antigen presentation
4. Heat shock protein 70-associated peptides elicit specific cancer immunity
5. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94
6. Cross-priming of minor histocompatibility antigen-specific cytotoxic T-cells upon immunization with the heat shock protein gp96
7. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24
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9. Capture and processing of exogenous antigens for presentation on MHC molecules
10. Mechanisms of MHC class I-restricted antigen processing
11. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
12. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis
13. Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
14. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
15. Bacterial proteins can be processed by macrophages in a transporter associated with antigen processing-independent, cysteine protease-dependent manner for presentation by MHC class I molecules
16. Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
17. Saturation, competition and specificity in interaction of heat shock proteins (hsp) gp96, hsp90 and hsp70 with CD11b+ cells
18. CD91: A receptor for heat shock protein gp96
19. Cutting edge: Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells
20. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine
21. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
22. Human 60-kDa heat-shock protein: A danger signal to the innate immune system
23. Heat shock proteins generate β-chemokines which function as innate adjuvants enhancing adaptive immunity
24. A proposed mechanism for the induction of cytotoxic T-lymphocyte production by heat shock fusion proteins
25. In vivo cytotoxic T-lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T-cell independent
26. A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic
27. Activation of T-cells recognizing self 60-kD heat shock protein can protect against experimental arthritis
28. A self-hsp60 peptide acts as a partial agonist inducing expression of B7-2 on mycobacterial hsp60-specific T-cells: A possible mechanism for inhibitory T-cell regulation of adjuvant arthritis?
29. Exaggerated human monocyte IL-10 concomitant to minimal TNFα induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus
30. Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death
31. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
32. The immune system evolved to discriminate infectious non-self from non-infectious self
33. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
34. Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells
35. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
36. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NFκB pathway
37. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs