An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD4OL interactions in a mouse model of atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 107, Issue 2, 2001, Pages 359-366

  Woodward, Amy L ^a   Spergel, Jonathan M ^a   Alenius, Harri ^a   Mizoguchi, Emiko ^a   Bhan, Atul K ^b   Castigli, Emanuela ^a   Brodeur, Scott R ^a   Oettgen, Hans C ^a   Geha, Raif S ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Atopic dermatitis; B cells; CD40; CD4OL; T cells; T cells

Indexed keywords

CD40 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; OVALBUMIN; OVALBUMIN ANTIBODY; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; B LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE DELETION; GENE TARGETING; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SENSITIZATION; SKIN DEFECT; T LYMPHOCYTE; TH2 CELL;

EID: 0035110177     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.112695     Document Type: Article

References (28)

1. Atopic dermatitis: The skin as a window into the pathogenesis of chronic allergic disease
2. Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis: Comparison with onchocerciasis
3. Dermal eosinophils in atopic dermatitis undergo cytolytic degeneration
4. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis
5. In vivo expression of IL-12 and IL-13 in atopic dermatitis
6. H1 response in situ: An immunocytochemical study
7. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice
8. H2 cytokines in a murine model of allergic dermatitis
9. Signaling checkpoints during the development of T lymphocytes
10. T-cell fate
11. Characterization of T cell receptors on resident murine dendritic epidermal T cells
12. Immunobiology of mouse dendritic epidermal T cells: A decade later, some answers, but still more questions
13. Role of γδ T lymphocytes in immune response in humans and mice
14. The many roles of CD40 in cell-mediated inflammatory responses
15. Exogenous CD40 ligand induces a pulmonary inflammation response
16. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
17. Induction of alloantigen-specific tolerance by B cells from CD40 deficient mice
18. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin in chain gene
19. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
20. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice
21. Colitis in transgenic and knockout animals as models of human inflammatory bowel disease
22. Peripheral lymphoid development and function of TCR mutant mice
23. Fine-specificity of the immune response to oxazolone. I. Contact sensitivity and early antibodies
24. Requirement for γδ T cells in allergic airway inflammation
25. Negative regulation of airway responsiveness that is dependent on γδ T cells and independent of αβ T cells
26. Aeroallergen-induced eosinophilic inflammation, lung damage, and airway hyperreactivity in mice can occur independently of IL-4 and allergen-specific inflammation
27. Disruption of antigen inflammatory responses in CD40 ligand knock-out mice
28. CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice