Constitutive intracellular expression and activation-induced cell surface up-regulation of CD44v3 in human T lymphocytes

European Journal of Immunology

Volumn 31, Issue 2, 2001, Pages 600-608

  Forster Horváth, Csaba ^a,b   Bocsi, József ^b   Rásó, Erzsébet ^a   Orbán, Tamás I ^a   Olah, Edith ^a,b   Tímár, József ^a,b   Ladányi, Andrea ^a  

^a NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Activation; CD44v3; Human; T lymphocyte

Indexed keywords

BIOLOGICAL MARKER; BREFELDIN A; CD44V ANTIGEN; CD44V3 ANTIGEN; CD44V6 ANTIGEN; CELL ADHESION MOLECULE; CYCLOHEXIMIDE; HERMES ANTIGEN; LYMPHOCYTE ANTIBODY; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANTIGEN EXPRESSION; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EXON; FLOW CYTOMETRY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; MORPHOLOGY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LEUKEMIA; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

ANTIGENS, CD44; CELL LINE; HUMANS; LYMPHOCYTE ACTIVATION; PROTEIN ISOFORMS; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; UP-REGULATION;

EID: 0035108535     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200102)31:2<600::AID-IMMU600>3.0.CO;2-8     Document Type: Article

References (55)

1. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
2. The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat
3. Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon
4. CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor
5. Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44
6. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β
7. Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-met
8. CD44 and its interaction with extracellular matrix
9. CD44 is the principal cell surface receptor for hyaluronate
10. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin
11. A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion
12. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44
13. CD44 contributes to T cell activation
14. Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation
15. LFA-3, CD44, and CD45: Physiologic triggers of human monocyte TNF and IL-1 release
16. Mechanism of peripheral T cell activation by coengagement of CD44 and CD2
17. Antibodies to CD44 trigger effector functions of human T cell clones
18. Enhancement of natural killer activity by an antibody to CD44
19. Hyaluronate-CD44 interactions can induce murine B-cell activation
20. Adhesive and/or signaling functions of CD44 isoforms in human dendritic cells
21. Signaling through CD44 is mediated by tyrosine kinase
22. CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes
23. Joint features of metastasis formation and lymphocyte maturation and activation
24. CD44 in malignant disorders
25. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
26. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44
27. Alternatively spliced CD44 transcripts in diffuse large-cell lymphomas: Characterization and comparison with normal activated B cells and epithelial malignancies
28. Expression of integrins and CD44 isoforms in non-Hodgkin's lymphomas: CD44 variant isoforms are preferentially expressed in high-grade malignant lymphomas
29. CD44v6 expression in non-Hodgkin's lymphoma: An association with low histological grade and poor prognosis
30. CD44 variant isoforms in non-Hodgkin's lymphoma: A new independent prognostic factor
31. A new CD44V3-containing isoform is involved in tumor cell growth and migration during breast carcinoma progression
32. Dialectics of the "metastasis markers" in pathology
33. Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms
34. Participation in normal immune response of a metastasis-inducing splice variant of CD44
35. Expression and modulation of CD44 variant isoforms in humans
36. Involvement of CD44 variant isoforms in hyaluronate adhesion by human activated T cells
37. CD44 isoforms containing exons V6 and V7 are differentially expressed on mitogenically stimulated normal and Epstein-Barr virus-transformed human B cells
38. In vitro culture of human peripheral blood monocytes induces hyaluronan binding and upregulates monocyte variant CD44 isoform expression
39. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α
40. An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function
41. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
42. 3-integrin in melanoma cells
43. Predominant expression of CD44 splice variant v10 in malignant and reactive human skin lymphocytes
44. CD44 variant isoform expression in a variety of skin-associated autoimmune diseases
45. CD44 variant isoforms on blood leukocytes in chronic inflammatory bowel disease and other systemic autoimmune disease
46. A strong expression of CD44-6v correlates with shorter survival of patients with acute myeloid leukemia
47. Human leucocyte heparan sulphate proteoglycans and their roles in inflammation
48. CD44 variants but not CD44s cooperate with β1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
49. Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44
50. Regulation of growth and dissemination of a human lymphoma by CD44 splice variants
51. Selective and differential binding of interleukin (IL)-1α, IL-1β, IL-2 and IL-6 to glycosaminoglycans
52. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis
53. IL-12 is a heparin-binding cytokine
54. Regulation of T cell homeostasis by heparan sulfate-bound IL-2
55. Expression of CD44 splice variants in normal, dysplastic, and neoplastic cervical epithelium