Erythromycin production in Saccharopolyspora erythraea does not require a functional propionyl-CoA carboxylase

Molecular Microbiology

Volumn 19, Issue 5, 1996, Pages 977-984

  Donadio, Stefano ^a,b   Staver, Michael J ^a   Katz, Leonard ^a  

^a ABBOTT LABORATORIES   (United States)

^b Gruppo Lepetit SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; ENZYME; ERYTHROMYCIN; PROPIONYL COENZYME A CARBOXYLASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGUS MUTANT; GENE CLUSTER; NONHUMAN; PRIORITY JOURNAL; SACCHAROPOLYSPORA;

FUNGI; MAMMALIA; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA ERYTHRAEA;

EID: 0029863416     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.439969.x     Document Type: Article

References (34)

1. Andersen, J.F., and Hutchinson, C.R. (1992) Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase. J Bacteriol 174: 725-735.
2. Browner, M.F., Taroni, F., Stzul, E., and Rosenberg, L.E (1989). Sequence analysis, biogenesis, and mitochondrial import of the α-subunit of rat liver propionyl-CoA carboxylase. J Biol Chem 264: 1280-1285.
3. Devereux, J., Haeberli, P., and Smithies, O. (1984) A comprehensive set of sequence analysis programs for the VAX. Nucl Acids Res 12: 387-395.
4. Donadio, S., Shafiee, A., and Hutchinson, C.R. (1990). Disruption of a rhodaneselike gene results in cysteine auxotrophy in Saccharopolyspora erythraea. J Bacteriol 171:350-360.
5. Donadio, S., Staver, M.J., McAlpine, J.B., Swanson, S.J., and Katz, L. (1991) Modular organization of genes required for complex polyketide biosynthesis. Science 252: 675-679.
6. Donadio, S., McAlpine, J.B., Sheldon, P.J., Jackson, M., and Katz, L. (1993a) An erythromycin analog produced by reprogramming polyketide synthesis. Proc Natl Acad Sci USA 90: 7119-7223.
7. Donadio, S., Stassi, D.L., Staver, M.J., McAlpine, J.B., Sheldon, P.J., Jackson, M., Swanson, S.J., Wendt-Pienkowski, E., Wang, Y.-G., Jarvis, B., Hutchinson, C.R., and Katz, L. (1993b) Recent developments in the genetics of erythromycin formation. In Genetics and Molecular Biology of Industrial Microorganisms. Baltz R.H., Ingolia T., and Hegeman G. (eds). Washington, DC: American Society for Microbiology, pp. 257-265.
8. 4-dicarboxylate carrier. J Bacteriol 171: 5551-5560.
9. Fall, R.R. (1979) Analysis of microbial biotin proteins. Meth Enzymol 62: 390-398.
10. Gornicki, P., Scappino, L.A., and Haselkorn, R. (1993) Genes for two subunits of acetyl coenzyme A carboxylase of Anabaena sp. strain PCC 7120: biotin carboxylase and biotin carboxyl carrier protein. J Bacteriol 175: 5268-5272.
11. Gottschalk, G. (1985) Bacterial Metabolism 2nd edn. New York: Springer Verlag.
12. Gygax, D., Stalder, R., and Nüesch, J. (1984) Propionyl-CoA carboxylase in Nocardia mediterranei. FEMS Microbiol Lett 23: 211-216.
13. Hopwood, D.A., Bibb, M.J., Chater, K.F., Kieser, T., Bruton, C.J., Kieser, H.M., Lydiate, D.J., Smith, C.P., Ward, J.M., and Schrempf, H. (1985) Genetic Manipulation of Streptomyces. A Laboratory Manual. Norwich: The John Innes Foundation.
14. Hsieh, Y.-J., and Kolattukudy, P.E. (1994) Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea. J Bacteriol 176: 714-724.
15. Huder, J.B., and Dimroth, P. (1993) Sequence of the sodium ion pump methylmalonyl-CoA decarboxylase from Veillonella parvula. J Biol Chem 268: 24564-24571.
16. Hunaiti, A.R., and Kolattukudy, P.E. (1982) Isolation and characterization of an acyl-Coenzyme A carboxylase from an erythromycin-producing Streptomyces erythreus. Arch Biochem Biophys 216: 362-371.
17. Katz, L., and Donadio, S. (1993) Polyketide synthesis: prospects for hybrid antibiotics. Annu Rev Microbiol 47: 875-912.
18. Kraus, J.P., Firgaira, F., Novotny, J., Kalousek, F., Williams, K.R., Williamson, C., Ohura, T., and Rosenberg, L.E. (1986) Coding sequence of the precursor of the beta-subunit of rat propionyl-CoA carboxylase. Proc Natl Acad Sci USA 83: 8049-8053.
19. Li, S.-J., and Cronan, Jr, J.E. (1992) The gene encoding the biotin carboxylase subunit of Escherichia coli acetyl-CoA carboxylase. J Biol Chem 267: 855-863.
20. Marsden, A.F.A., Caffrey, P., Aparicio, J.F., Loughran, M.S., Staunton, J., and Leadlay, P.F. (1994) Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science 263: 378-380.
21. Martín, J.F., and Liras, P. (1989) Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites. Annu Rev Microbiol 43: 173-206.
22. Nagy, I., Schoofs, G., Vanderleyden, J., and De Mot, R. (1992) Sequence of a Rhodococcus gene encoding a protein with extensive homology to the mammalian propionyl-CoA carboxylase beta chain. Gene 122: 199-202.
23. Norman, E., De Smet, K.A., Stoker, N.G., Ratledge, C., Wheeler, P.R. and Dale, J.W. (1994) Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis. J Bacteriol 176: 2525-2531.
24. Norman, E., Dellagostin, O.A., McFadden, J. and Dale, J.W. (1995) Gene replacement by homologous recombination in Mycobacterium bovis BCG. Mol Microbiol 16: 755-760.
25. Samols, D., Thornton, C.G., Murtif, V.L., Kumar, G.K., Haase, F.C., and Wood, H.G. (1988). Evolutionary conservation among biotin enzymes. J Biol Chem 263: 6462-6464.
26. Tang, L., Zhang, Y.-X., and Hutchinson, C.R. (1994) Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. J Bacteriol 176: 6107-6119.
27. Thornton, C.G., Kumar, G.K., Haase, F.C., Phillips, N.F.B., Woo, S.B., Park, V.M., Magner, W.J., Shenoy, B.C., Wood, H.G., and Samols, D. (1993) Primary structure of the monomer of the 12S subunit of transcarboxylase as deduced from DNA and characterization of the product expressed in Escherichia coli. J Bacteriol 175: 5301-5308.
28. Tinoco, Jr, I., Borer, P.N., Dengler, B., Levine, M.D., Uhlenbeck, O.C., Crothers, D.M., and Gralla, J. (1973) Improved estimation of secondary structure in ribonucleic acids. Nature 246: 40-41.
29. Toh, H., Kondo, H., and Tanabe, T. (1993) Molecular evolution of biotin-dependent carboxylases. Eur J Biochem 215: 687-696.
30. Tolner, B., Poolman, B., and Konings, W.N. (1992) Characterization and functional expression in Escherichia coli of the sodium-proton-glutamate symport proteins of Bacillus stearothermophilus and Bacillus caldotenax. Mol Microbiol 6: 2845-2856
31. Tuan, J.S., Weber, J.M., Staver, M.J., Leung, J.O., Donadio, S., and Katz, L. (1990) Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid. Gene 90: 21-29.
32. Vara, J.A., Lewandoska-Skarbek, M., Wang, Y.-G., Donadio, S., and Hutchinson, C.R. (1989) Cloning of genes governing the deoxysugar portion of the erythromycin biosynthetic pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J Bacteriol 170: 5872-5881.
33. Vieira, J., and Messing, J. (1982) The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19: 259-268.
34. Wright, F., and Bibb, M.J. (1992) Codon usage in the G+C-rich Streptomyces genome. Gene 113: 55-65.