A modified citrulline assay of NOS activity in rat brain homogenates does not detect direct effects of halothane on the kinetics of NOS activity

Brain Research

Volumn 767, Issue 2, 1997, Pages 393-396

  Tagliente, Thomas M ^a,b   Craddock Royal, Barbara ^b   Beasley, Joseph ^b   Maayani, Saul ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Anesthetic; Halothane; Inhalational; Nitric oxide; Nitric oxide synthase; Rat brain

Indexed keywords

ARGININE; CITRULLINE; HALOTHANE; INHALATION ANESTHETIC AGENT; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN MEMBRANE; CEREBELLUM; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RAT; SPINAL CORD;

ANIMALS; BRAIN; CITRULLINE; CYTOSOL; HALOTHANE; KINETICS; LINEAR MODELS; MALE; MEMBRANES; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0342683868     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00825-1     Document Type: Article

References (17)

1. Adachi T., Kurata J., Nakao S., Murakawa M., Shichino T., Shirakami G., Shinomura T., Mori K. Nitric oxide synthase inhibitor does not reduce minimum alveolar anesthetic concentration of halothane in rats. Anesth. Analg. 78:1994;1154-1157.
2. Adachi T., Shinomura T., Nakao S., Kurata J., Murakawa M., Shichino T., Seo N., Mori K. Chronic treatment with nitric oxide synthase (NOS) inhibitor profoundly reduces cerebellar NOS activity and cyclic guanosine monophosphate but does not modify minimum alveolar anesthetic concentration. Anesth. Analg. 81:1995;862-865.
3. Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in cerebellum. Proc. Natl. Acad. Sci. USA. 86:1989;9030-9033.
4. Galley H.F., Nelson L.R., Webster N.R. Anaesthetic agents decrease the activity of nitric oxide synthase from human polymorphonuclear leukocytes. Br. J. Anaesth. 75:1995;326-329.
5. Hart J.L., Jing M., Bina S., Freas W., Van Dyke R.A., Muldoon S.M. Effects of halothane on EDRF/cGMP-mediated vascular smooth muscle relaxations. Anesthesiology. 79:1993;323-331.
6. G-L-arginine methylester on the threshold for isoflurane anesthesia. Anesthesiology. 83:1995;101-108.
7. Johns R.A., Moscicki J.C., DiFazio C.A. Nitric oxide synthase inhibitor dose-dependently and reversibly reduces the threshold for halothane anesthesia: a role for nitric oxide in mediating consciousness. Anesthesiology. 77:1992;779-784.
8. Johns R.A., Tichotsky A., Muro M., Spaeth J.P., Le Cras T.D., Rengasamy A. Halothane and isoflurane inhibit endothelium-derived relaxing factor-dependent cyclic guanosine monophosphate accumulation in endothelial cell-vascular smooth muscle co-cultures independent of an effect on guanylyl cyclase activation. Anesthesiology. 83:1995;823-834.
9. Knowles R.G., Moncada S. Nitric oxide synthases in mammals. Biochem. J. 298:1994;249-258.
10. Moncada S. The L-arginine : nitric oxide pathway, cellular transduction and immunological roles. Adv. Second Messenger Phosphoprotein Res. 28:1993;97-99.
11. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
12. G-L-arginine methyl ester, dose dependently reduce the threshold for isoflurane anesthesia. Anesthesiology. 85:1996;1111-1119. Abstract.
13. Rengasamy A., Pajewski T.N., Johns R.A. Inhalational anesthetic effects on rat cerebellar nitric oxide and cyclic guanosine monophosphate production. Anesthesiology. 86:1997;689-698. Abstract.
14. Rengasamy A., Ravichandran L.V., Reikersdorfer C.G., Johns R.A. Inhalational anesthetics do not alter nitric oxide synthase activity. J. Pharmacol. Exp. Ther. 273:1995;599-604.
15. Terasako K., Nakamura K., Miyawaki I., Toda H., Kakuyama M., Mori K. Inhibitory effects of anesthetics on cyclic guanosine monophosphate (cGMP) accumulation in rat cerebellar slices. Anesth. Analg. 79:1994;921-926.
16. Tobin J.R., Martin L.D., Breslow M.J., Traystman R.J. Selective anesthetic inhibition of brain nitric oxide synthase. Anesthesiology. 81:1994;1264-1269.
17. Zuo Z., Johns R.A. Halothane, enflurane, and isoflurane do not affect the basal or agonist-stimulated activity of partially isolated soluble and particulate guanylyl cyclases of rat brain. Anesthesiology. 83:1995;395-404.