Structure/function of C5 convertases of complement

International Immunopharmacology

Volumn 1, Issue 3, 2001, Pages 415-422

  Rawal, Nenoo ^a   Pangburn, Michael K ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Alternative pathway; C3 convertase; C5; C5 convertase; Complement

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C5; COMPLEMENT MEMBRANE ATTACK COMPLEX; DIMER;

BINDING AFFINITY; BINDING SITE; COMPLEMENT BLOOD LEVEL; CONFERENCE PAPER; CYTOLYSIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME BLOOD LEVEL; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; HUMAN; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; COMPLEMENT C3; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT C5; HUMANS; KINETICS; MODELS, BIOLOGICAL;

EID: 0035094142     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(00)00039-4     Document Type: Conference Paper

References (64)

1. Alternative pathway: Activation and regulation
2. Classical pathway of activation
3. Lectin pathway of non-recognition
4. Structure, function and cellular expression of complement anaphylatoxin receptors
5. Complement in inflammation
6. Complement system in coronary heart disease: A review
7. Role of complement in graft rejection
8. Complement deficiences in humans
9. Complement biosynthesis in the central nervous system
10. Complement-specific antibodies: Designing novel anti-inflammatories
11. Anti-C5 single chain antibody therapy blocks complement and leukocyte activation and reduces myocardial tissue damage in CPB patients
12. Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs
13. Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies
14. Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a
15. Pharmacological manipulation of complement system
16. Synthetic peptide inhibitors of complement serine proteases: I. Identification of functionally equivalent protease inhibitor sequences in serpins and inhibition of C1s and D
17. Complement: A host defense mechanism ready for pharmacological manipulation?
18. Therapeutic inhibition of the complement system
19. The regulation of complement activity by pharmacologic agents
20. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library
21. The effect of FUT-175 (nafamstat mesilate) on C3a, C4a and C5a generation in vitro and inflammatory reactions in vivo
22. Substituted isocoumarins as inhibitors of complement serine proteases
23. A soluble chimeric complement inhibitory protein that possesses both decay-accelerating and factor I cofactor activities
24. Therapeutic regulation of the complement system in acute injury states
25. Soluble human complement receptor 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis
26. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage
27. C5 convertase of the alternative pathway of complement. Kinetic analysis of the free and surface-bound forms of the enzyme
28. Functional role of the noncatalytic subunit of complement C5 convertase
29. Isolation of the anticomplementary protein from cobra venom and its mode of action on C3
30. Structure and function of cobra venom factor, the complement-activating protein in cobra venom
31. Formation and function of a complex of the C3 proactivator with a protein from cobra venom
32. The activation of human complement component C5 by a fluid phase C5 convertase
33. The C3-activator system: An alternative pathway of complement activation
34. The influence of C3b inactivator (KAF) concentration of the ability of serum to support complement activation
35. Activation of terminal components of human complement by a trypsin-activated complex of human factor B and cobra venom factor, Japan
36. Ultrastructure of cobra venom factor-dependent C3/C5 convertase and its zymogen, factor B of human complement
37. The cobra venom factor-dependent C3 convertase of human complement. A kinetic and thermodynamic analysis of a protease acting on its natural high molecular weight substrate
38. Alternative pathway for the activation of complement in human serum: Formation and composition of the complex with cobra venom factor that cleaves the third component of complement
39. Comparison of Naja n. naja and Naja h. haje cobra-venom factors: correlation between binding affinity for the fifth component of complement and mediation of its cleavage
40. The activation of C5 in the fluid phase and in the absence of C3 through the classical pathway of the complement system
41. A covalent dimer of complement C4b serves as a subunit of a novel C5 convertase that involves no C3 derivatives
42. C3 requirements for formation of alternative pathway C5 convertase
43. The interaction of C5 with C3b in free solution: A sufficient condition for cleavage by fluid phase C3/C5 convertase
44. C5 convertase of the alternative complement pathway: Covalent linkage between two C3b molecules within the trimolecular complex enzyme
45. Alternative pathway of complement: Recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway
46. A molecular concept of the properdin pathway
47. Covalent association of C3b with C4b within C5 convertase of the classical complement pathway
48. A new function of the activated third component of complement: Binding to C5, an essential step for C5 activation
49. The binding of human complement proteins C5, factor B, BIH and properdin to complement fragment C3b on zymosan
50. The conversion of human complement component C5 into fragment C5b by the alternative pathway C5 convertase
51. Reconstitution of C5 convertase of the alternative complement pathway with isolated C3b dimer and factors B and D
52. Covalent binding of C3b to C4b within the classical complement pathway C5 convertase. Determination of amino acid residues involved in ester linkage formation
53. Localization of the covalent C3b-binding site on C4b within the complement classical pathway C5 convertase, C4b2a3b
54. MHC class III products: An electron microscopic study of the C3 convertases of human complement
55. Electron microscopy and image processing studies of the structures of the complement proteins C3 and C3b
56. Formation of covalently linked C3-C3 dimers on IgG immune complexes
57. Assembly and regulation of the complement amplification loop in blood: The role of C3b-C3b-IgG complexes
58. Distal recognition site for classical pathway convertase located in the C345C/Netrin module of complement C5
59. Formation of high affinity C5 convertases of the alternative pathway of complement
60. A general purpose RNA-cleaving DNA enzyme
61. Immune versus natural selection: Antibody aldolases with enzymic rates but broader scope
62. C3b deposition during activation of the alternative complement pathway and the effect of deposition of the activating surface