Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a

Anesthesia and Analgesia

Volumn 89, Issue 1, 1999, Pages 42-48

  Park, Kyung W ^a,c   Tofukuji, Motohisa ^a   Metais, Caroline ^a   Comunale, Mark E ^a   Dai, Hai B ^a   Simons, Michael ^a   Stahl, Gregory L ^b   Agah, Azin ^b   Sellke, Frank W ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Dept Anesthesia and Critical Care ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; COMPLEMENT COMPONENT C5A; MONOCLONAL ANTIBODY; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; SODIUM CHLORIDE; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; IMMUNOBLOTTING; LUNG BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTERIOLES; CARDIOPULMONARY BYPASS; COMPLEMENT C5A; ENDOTHELIUM, VASCULAR; FEMALE; LUNG; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PEROXIDASE; SWINE; VASODILATION;

EID: 0033014630     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199907000-00008     Document Type: Article

References (27)

1. Shafique T, Johnson RG, Dai HB, et al. Altered pulmonary microvascular reactivity after total cardiopulmonary bypass. J Thorac Cardiovasc Surg 1993;106:479-86.
2. Park KW, Dai HB, Lowenstein E, et al. Effect of isoflurane on the β-adrenergic and endothelium-dependent relaxation of pig cerebral microvessels after cardiopulmonary bypass. J Stroke Cerebrovasc Dis 1998;7:168-78.
3. Boyle EM, Pohlman TH, Johnson MC, Verrier ED. The systemic inflammatory response. Ann Thorac Surg 1997;64:S31-7.
4. Chenoweth DE, Cooper SW, Hugli TE, et al. Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 1981;304:497-503.
5. Moat NE, Rebuck N, Shore DF, et al. Humoral and cellular activation in a simulated extracorporeal circuit. Ann Thorac Surg 1993;56:1509-14.
6. Gillinov AM, DeValeria PA, Winkelstein JA, et al. Complement inhibition with soluble complement receptor type 1 in cardiopulmonary bypass. Ann Thorac Surg 1993;55:619-24.
7. Friedman M, Wang SY, Stahl GL, et al. Altered β-adrenergic and cholinergic pulmonary vascular responses after total cardiopulmonary bypass. J Appl Physiol 1995;79:1998-2006.
8. Stahl GL, Reenstra WR, Frendl G. Complement-mediated loss of endothelium-dependent relaxation of porcine coronary arteries: role of the terminal membrane attack complex. Circ Res 1995; 76:575-83.
9. Tofukuji M, Stahl GL, Agah A, et al. Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction. J Thorac Cardiovasc Surg 1998;116:1060-8.
10. Amsterdam EA, Stahl GL, Pan H-L, et al. Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs. Am J Physiol 1995;268:H448-57.
11. Zhang JL, Patel JM, Block ER. Molecular cloning, characterization and expression of a nitric oxide from porcine pulmonary artery endothelial cells. Comp Biochem Physiol B Mol Biol 1997;116:485-91.
12. Geller DA, Lowenstein CJ, Shapiro RA, et al. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci USA 1993;90:3491-5.
13. Park KW, Dai HB, Lowenstein E, et al. Heterogeneous vasomotor responses of rabbit coronary microvessels to isoflurane. Anesthesiology 1994;81:1190-7.
14. Shimokawa H, Kim P, Vanhoutte PM. Endothelium-dependent relaxation to aggregating platelets in isolated basilar arteries of control and hypercholesterolemic pigs. Circ Res 1988;63:604-12.
15. Egashira K, Inou T, Hirooka Y, et al. Evidence of impaired endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary angiograms. N Engl J Med 1993;328:1659-64.
16. Johns RA, Peach MJ, Flanagan T, Kron IL. Probing of the canine mammary artery damages endothelium and impairs vasodilation resulting from prostacyclin and endothelium-derived relaxing factor. J Thorac Cardiovasc Surg 1989;97:252-8.
17. Banitt PF, Shafique T, Weintraub RM, et al. Relaxation responses of the coronary microcirculation after cardiopulmonary bypass and ischemic arrest with cardioplegia: implications for the treatment of postoperative coronary spasm. J Cardiothorac Vasc Anesth 1993;7:55-60.
18. Carraway MS, Piantadosi CA, Jenkinson CP, Huang YC. Differential expression of arginase and iNOS in the lung in sepsis. Exp Lung Res 1998;24:253-68.
19. Quillen JE, Sellke FW, Brooks LA, Harrison DG. Ischemiareperfusion impairs endothelium-dependent relaxation of coronary microvessels but does not affect large arteries. Circulation 1990;82:586-94.
20. Friedman M, Johnson RG, Wang SY, et al. Pulmonary microvascular responses to protamine and histamine: effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1994;108:1092-9.
21. Knudsen F, Andersen LW. Immunological aspects of cardiopulmonary bypass. J Cardiothorac Anesth 1990;4:245-58.
22. Nilsson L, Kulander L, Nystrom S-O, Eriksson O. Endotoxins in cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990;100: 777-80.
23. Moore FD, Warner KG, Assousa S, et al. The effects of complement activation during cardiopulmonary bypass: attenuation by hypothermia, heparin, and hemodilution. Ann Surg 1988;208: 95-103.
24. Homeister JW, Satoh P, Lucchesi BR. Effects of complement activation in the isolated heart: role of the terminal complement components. Circ Res 1992;71:303-19.
25. Smith EF III, Egan JW, Bugelski PJ, et al. Temporal relation between neutrophil accumulation and myocardial reperfusion injury. Am J Physiol 1988;255:H1060-8.
26. Shandelya SML, Kuppusamy P, Weisfeldt ML, Zweier JL. Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Circulation 1993; 87:536-46.
27. Amsterdam EA, Pan H-L, Rendig SV, et al. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocker by inhibition of neutrophil activity without reduction of neutrophil migration. J Am Coll Cardiol 1993;22:1738-44.