Regulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of phosphatidylinositol 3-kinase activity

EMBO Reports

Volumn 2, Issue 1, 2001, Pages 68-74

  Chen, X ^a   Wang, Z ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AUTOANTIGEN; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; PROTEIN SUBUNIT; RAB PROTEIN; RABAPTIN 5; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL FUSION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; INTRACELLULAR TRANSPORT; LYSOSOME; MEMBRANE FUSION; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELL LINE; CHROMONES; DOGS; ENDOCYTOSIS; ENDOSOMES; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOBLOTTING; LYSOSOMES; MEMBRANE PROTEINS; MICROINJECTIONS; MORPHOLINES; MUTATION; RAB5 GTP-BINDING PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TIME FACTORS; TRANSFECTION; VESICULAR TRANSPORT PROTEINS;

ANIMALIA;

EID: 0035093445     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve005     Document Type: Article

References (22)

1. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
2. The Rab5 effector EEA1 is a core component of endosome docking
3. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
4. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
5. FYVE fingers bind PtdIns(3)P
6. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion
7. Direct association of p110β phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110β
8. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
9. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites
10. Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5
11. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase
12. A functional PtdIns(3)P-binding motif
13. Phosphatidylinositol-3-OH kinase as a direct target of Ras
14. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
15. Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin
16. Distinct roles for the p110α and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
17. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
18. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
19. Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
20. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
21. Phosphoinositide 3-kinases: A conserved family of signal transducers
22. Requirement for the adapter protein GRB2 in EGF receptor endocytosis