The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4

Development (Cambridge)

Volumn 128, Issue 4, 2001, Pages 551-560

  Gomez Skarmeta J L ^a,b   de la Calle Mustienes, E ^a,b   Modolell, J ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

BMP4; Homeodomain repressor; Iroquois; Wnt signaling; Xenopus

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; HOMEODOMAIN PROTEIN; PROTEIN XIRO 1; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; GASTRULATION; GENE EXPRESSION; GENETIC CODE; MULTIGENE FAMILY; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; REPRESSOR GENE; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALIA;

EID: 0035090548     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Wnt signalling in Xenopus embryos inhibits Bmp4 expression and activates neural development
2. Regulation of chamber-specific gene expression in the developing heart by Irx4
3. X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation
4. Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification
5. Anterior neuroectodermis progressively induced during gastrulation: The role of the Xenopus homeobox gene orthodenticle
6. Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
7. Compartments and organising boundaries in the Drosophila eye: The role of the homeodomain Iroquois proteins
8. The Iroquois homeobox genes function as dorsal selectors in the Drosophila head
9. Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye
10. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
11. The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila
12. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye
13. Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
14. The dorsalizing and neural inducing gene Follistatin is an antagonist of BMP-4
15. On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo
16. XASH genes promote neurogenesis in Xenopus embryos
17. Antagonizing the Spemann organizer: Role of the homeobox gene Xvent-1
18. Araucan and caupolican, two members of the novel Iroquois complex, encode homeoproteins that control proneural and vein forming genes
19. Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate
20. Genetic analysis of dorsoventral pattern formation in the zebrafish: Requirement of a BMP-like ventralizing activity and its dorsal repressor
21. In situ hybridization: An improved whole mount method for Xenopus embryos
22. Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA
23. Formation and function of Spemann's organizer
24. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and display direct neuralizing activity
25. Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP-2 and BMP-4
26. MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos
27. Epidermal keratin gene expressed in embryos of Xenopus laevis
28. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction
29. Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm
30. Efficient hormone-inducible protein function in Xenopus laevis
31. The nieuwkoid/dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula
32. Neural induction by the secreted polypeptide noggin
33. Establishment of the dorsal-ventral axis in Xenopus is presaged by early asymetries in beta-catenin that are modulated by the Wnt signalling pathway
34. Goosecoid and Mix.1 repress Brachyury expression and are required for head formation in Xenopus
35. A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone
36. Iroquois: A prepattern gene that controls the formation of bristles on the thorax of Drosophila
37. Identification of neurogenin, a vertebrate neuronal determination gene
38. A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm
39. Specification of anterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin
40. Wnt and FGF pathways cooperatively pattern anteriorposterior neural ectoderm in Xenopus
41. Direst regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus
42. Structural and functional analysis of the BMP-4 promoter in early embryo of Xenopus laevis
43. Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction
44. SoxD: An essential mediator of induction of anterior neural tissues in Xenopus embryos
45. Xtcf-3 transcription factor mediates β-catenin-induced axix formation in Xenopus embryos
46. From cortical rotation to organizer gene expression: Towards a molecular explanation of axis specification in Xenopus
47. Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2/swirl pathway of genes
48. The Xenopus homologue of Otx-2 is a maternal homeobox gene that demarcate and specifies anterior body regions
49. Dorsal-ventral signaling in the Drosophila eye
50. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
51. Cleavage of Chordin by Xolloid metalloprotease suggests a role of proteolytic processing in the regulation of Spemann organizer activity
52. Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of the Xenopus eggs
53. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeoboxes genes
54. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
55. Ectodermal patterning in vertebrate embryos
56. Identifying the missing links: Genes that connect neural induction and primary neurogenesis in vertebrate embryos
57. Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos
58. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
59. Secreted noggin protein mimic the Spemann organizer in dorsalizing mesoderm
60. Bone morphogenetic proteins acts as a ventral mesoderm modifier in early Xenopus embryos
61. Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4
62. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
63. Neural induction
64. Induction of epidermis and inhibition of neural fate by Bmp-4
65. A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm
66. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
67. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4