Enterococcus faecalis multi-drug resistance transporters: Application for antibiotic discovery

Journal of Molecular Microbiology and Biotechnology

Volumn 3, Issue 2, 2001, Pages 179-184

  Davis, Deborah Vr ^a   McAlpine, James B ^a   Pazoles, Christopher J ^a   Talbot, M Kelly ^a   Alder, Elisabeth A ^a   White, Abbie C ^a   Jonas, Brandie M ^b   Murray, Barbara E ^b   Weinstock, George M ^b   Rogers, Bruce L ^a,c  

^a Phytera Inc   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AMPICILLIN; ANTIBIOTIC AGENT; AZITHROMYCIN; BACITRACIN; CHLORAMPHENICOL; CHLORHEXIDINE; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; DALFOPRISTIN PLUS QUINUPRISTIN; DAUNORUBICIN; DOXORUBICIN; ENOXACIN; ERYTHROMYCIN; ETHIDIUM BROMIDE; GENTAMICIN; GLYCOPROTEIN P; LINCOMYCIN; LINEZOLID; NORFLOXACIN; NOVOBIOCIN; OFLOXACIN; PENTAMIDINE; SPIRAMYCIN; TETRACYCLINE; TYLOSIN; UNINDEXED DRUG; VIRGINIAMYCIN; VIRGINIAMYCIN M;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIUM MUTANT; CELL STRAIN; CONFERENCE PAPER; DATA BASE; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG TRANSPORT; ENTEROCOCCUS FAECALIS; FUNCTIONAL ASSESSMENT; GENE DELETION; GENE DISRUPTION; GENE INACTIVATION; GENE INSERTION SEQUENCE; GENOME; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PHARMACEUTICAL ENGINEERING; PHENOTYPE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; TRANSPORT KINETICS;

ANTI-BACTERIAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CARRIER PROTEINS; DATABASES; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; ENTEROCOCCUS FAECALIS; GENE DELETION; GENOMICS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS;

EID: 0035087582     PISSN: 14641801     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (38)

1. Basic local alignment search tool
2. Efficiency and toxicity of Synercid (Quinupristin/Dalfopristin) [SYN(Q/D)] for vancomycin-resistant Enterococcus faecium (VREF) infections
3. The multidrug efflux protein NorM is a prototype of a new family of transporters
4. Streptogramin, a new antibiotic
5. Internal duplication and homology with bacterial transport proteins in mdr1 (p-glycoprotein) gene from multi-resistant human cells
6. Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae
7. Enterococci and vancomycin resistance
8. Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae
9. Germ warfare. A drug-resistant staph strain has doctors on edge
10. SOSUI: Classification and secondary structure prediction for membrane proteins
11. The PROSITE database, its status in 1999
12. Quinolone mode of action
13. Bacteria lacking a multidrug pump: A sensitive tool for drug discovery
14. In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network
15. Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance
16. Microbial multidrug resistance pumps: New developments and clinicial significance
17. Activity of macrolides, lincosamides, streptogramins and fluoroquinolones against Streptococcus pneumoniae and enterococci isolates from the western hemisphere
18. Emergence of superinfection with Enterococcus faecalis during RP 59500 treatment of Vancomycin-resistant Enterococcus faecalis infection (VREF)
19. Active efflux of antimicrobial agents in wild-type strains of Enterococci
20. In vitro activities of linezolid, trovofloxacin, and Quinupristin-Dalfopristin against sensitive and multiresistant gram positive organisms
21. Reduced susceptibility of Staphylococcus aureus to vancomycin-Japan, 1996
22. Sequence comparision of yeast ATP-binding cassette proteins
23. Multidrug efflux pumps of gram-negative bacteria
24. Proton-dependent multidrug efflux systems
25. What new things are going to kill me?
26. Targeted mutagenesis of enterococcal genes
27. Identification of the satA gene in E. faecium BM4145
28. Oxazolidinones, a new class of synthetic antibacterial agents
29. BCM Search Launcher: An integrated interface to molecular biology database search and analysis services available on the World Wide Web
30. Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium
31. A preliminary report on antibiotic number 899, a streptogramin-like substance
32. Association between quinupristin/dalfopristin resistance in glycopeptide-resistant E. faecium and the use of additives in animal feed
33. Beauty: An enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results
34. BEAUTY-X: Enhanced BLAST searches for DNA queries
35. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones