Pathways of mucin O-glycosylation in normal and malignant rat colonic epithelial cells reveal a mechanism for cancer-associated Sialyl-Tn antigen expression

Biological Chemistry

Volumn 382, Issue 2, 2001, Pages 219-232

  Brockhausen, I ^a   Yang, J ^a   Lehotay, M ^a   Ogata, S ^a   Itzkowitz, S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Colon cancer; Glycosyltransferases; Mucin biosynthesis; Rat colon; Sialyl Tn antigen

Indexed keywords

CELL SURFACE PROTEIN; CYTIDINE PHOSPHATE; EPITOPE; FUCOSYLTRANSFERASE; GALACTOSYLTRANSFERASE; GLYCAN DERIVATIVE; GLYCOSYLTRANSFERASE; MEMBRANE ANTIGEN; MUCIN; N ACETYLGLUCOSAMINE; SERINE DERIVATIVE; SIALIC ACID DERIVATIVE; SIALYLTRANSFERASE; THREONINE; TUMOR ANTIGEN; TUMOR MARKER;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CELL SURFACE; COLON MUCOSA; COLORECTAL CANCER; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; EPITHELIUM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN GLYCOSYLATION; RAT; REGULATORY MECHANISM; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; CARBOHYDRATE SEQUENCE; CELL DIVISION; COLONIC NEOPLASMS; EPITHELIAL CELLS; GASTRIC MUCOSA; GLYCOSYLATION; MOLECULAR SEQUENCE DATA; MUCINS; N-ACETYLGLUCOSAMINYLTRANSFERASES; POLYSACCHARIDES; RATS; REFERENCE VALUES; SIALYLTRANSFERASES; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0035083062     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.029     Document Type: Article

References (79)

1. Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen
2. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a β-1,6-N-acetylglucosaminyltransferase gene family
3. Mucin production in human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis
4. Liver metastasis and selectin-mediated adhesion to the sinusoidal endothelium by human colon cancer cells is related to mucin carbohydrate structure
5. Liver metastasis and adhesion to the sinusoidal endothelium by human colon cancer cells is related to mucin carbohydrate chain length
6. Mucin synthesis VI. UDP-GlcNAc:GalNAc-R β3-N-acetylglucosaminyl-transferase and UDP-GlcNAc:GlcNAcβ1-3GalNAc-R (GlcNAc to GalNAc) β6-N-acetylglucosaminyltransferase from pig and rat colon mucosa
7. 2 by a β6-N-acetylglucosaminyltransferase in pig gastric mucosa
8. Control of glycoprotein synthesis: The peptide portion of synthetic O-glycopeptide substrates influences the activity of O-glycan core 1 uridine 5'-diphospho-galactose:N-acetylgalactosamineα-R β3-galactosyltransferase
9. Glycosyltransferase changes upon differentiation of CaCo-2 human colonic adenocarcinoma cells
10. Biosynthesis of O-glycans of the N-acetylgalactosamine-α-Ser/Thr linkage type
11. Specificity of peptide glycosylation by polypeptide α-N-acetylgalactosaminyltransferase from bovine colostrum using, synthetic glycopeptide substrates
12. Mechanism underlying aberrant glycosylation of the MUC1 mucin in breast cancer cells
13. Enzymatic basis for sialyl-Tn expression in human colon cancer cells
14. Glycoproteins and their relationship to human disease
15. Pathways of O-glycan biosynthesis in cancer cells
16. Lectin binding sites in neoplastic and non-neoplastic colonic mucosa of 1,2-dimethylhydrazine-treated rats
17. Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine
18. A family of UDP-GalNAc: Polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation
19. X. Cis-Golgi resident proteins and O-glycans are abnormally compartmentalized in the RER of colon cancer cells
20. Increase of rat colon carcinoma cells tumorigenicity by α(1-2) fucosyltransferase gene transfection
21. O-glycan core 1 UDP-Gal:GalNAc β3-galactosyltransferase is controlled by the amino acid sequence and glycosylation of glycopeptide substrates
22. Branching beta 1-6N-acetylglucosaminyltransferase and polylactosamine expression in mouse F9 teratocarcinoma cells and differentiated counterparts
23. Cloning and expression of a human gene encoding an N-acetylgalactosamine-α2,6-sialyltransferase (ST6GalNAc I): A candidate for synthesis of cancer-associated sialyl-Tn antigens
24. A novel glycosyltransferase with a polyglutamine repeat: A new candidate for GD1alpha synthase (ST6GalNAc V) (1)
25. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer
26. Sialosyl-Tn: A novel mucin antigen associated with prognosis in colorectal cancer patients
27. Mucin-associated Tn and sialosyl-Tn antigen expression in colorectal polyps
28. Sialosyl-Tn antigen is prevalent and precedes dysplasia in ulcerative colitis: A retrospective case-control study
29. Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium
30. Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: Relation to dysplasia and DANN aneuploidy
31. Sequence and expression of a candidate for the human secretor blood group alpha(1,2)fucosyltransferase gene (FUT2)-homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype
32. Mucin glycoproteins in neoplasia
33. Perspectives on the significance of altered glycosylation of glycoproteins in cancer
34. Two different glycosyltransferase defects that result in GalNAcα-O-peptide (Tn) expression
35. Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells
36. Processing O-glycan core 1, Galβ1-3GalNAcα-R. Specificities of core 2 UDP-GlcNAc:Galβ1-3GalNAc-R β6-N-acetylglucosaminyl-transferase and CMP-SA:Galβ1-3GalNAc-R α3-sialyltransferase
37. Characterization of sulfotransferase activity from rat colonic mucosa synthesizing sulfated O-glycan core 1,3-sulfate-Galβ1-3GalNAcα-R
38. Core 2 β-1,6-N-acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin
39. Molecular cloning and expression of GalNAc alpha 2,6-sialyltransferase
40. Cloning and expression of Gal beta 1,3GalNAc-specific GalNAc alpha 2,6-sialyltransferase
41. Molecular cloning and genomic analysis of mouse Galβ1-3GalNAc-specific GalNAc α2,6-sialyltransferase
42. Molecular cloning and genomic analysis of mouse GalNAc α2,6-sialyltransferase (ST6GalNAc I)
43. Molecular cloning and functional expression of two members of mouse NeuAcα2,3Galβ1,3GalNAc GalNAc α2,6-sialyltransferase family, ST6GalNAc III and IV
44. Biosynthesis of branched polylactosaminoglycans. Embryonal carcinoma cells express midchain beta 1,6-N-acetylglucosaminyltransferase activity that generates branches to preformed linear backbones
45. Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P-and E-selectin
46. 13C NMR analysis of the pentasaccharide Gal beta (1-4) GlcNAc beta (1-3)-[GlcNAc beta (1-6)] Gal beta (1-4) GlcNAc synthesized by the mid-chain beta- (1-6)-D-N-acetylglucosaminyl-transferase of rat serum
47. The centrally acting beta 1,6N-acetylglucosaminyl-transferase (GlcNAc to Gal). Functional expression, purification, and acceptor specificity of a human enzyme involved in midchain branching of linear poly-N-acetyllactosamines
48. Expression of sialyl-Tn predicts the effect of adjuvant chemotherapy in node-positive breast cancer
49. x expression level in human pre-B lymphocytic leukemia cell line KM3 treated with phorbolester
50. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue
51. Expression of human tumor mucin-associated carbohydrate epitopes, including sialylated Tn, and localization of murine monoclonal antibodies CC49 and B72.3 in a syngeneic rat colon carcinoma model
52. Mucins bearing the cancer-associated sialylosyl-Tn antigen mediate inhibition of natural killer cell cytotoxicity
53. Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen
54. Molecular cloning of brain-specific GD1α synthase (ST6GalNAc V) containing CAG/glutamine repeats
55. Molecular cloning and expression of mouse GD1alpha/GD1a alpha/GQ1b alpha synthase (ST6GalNAc VI) gene
56. b blood group antigens in human colon by α-2-L-fucosylation
57. Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis
58. Oligosaccharide structures of isolated human colonic mucin species
59. Oligosaccharide structures of human colonic mucin species
60. Preferred Conformations and Dynamics of five core structures of mucin-type O-glycans determined by NMR spectroscopy and force field calculations
61. Compartmentation of glycoprotein biosynthesis
62. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells
63. Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel β1,6-N-acetylglucosaminyl-transferase forming core 2 and core 4
64. Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 beta1,6-N-acetylglucosaminyltransferase
65. Carcinoma-associated expression of core 2β-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: Role of O-glycans in tumor progression
66. Isolation and characterization of oligosaccharides from rat colonic mucus glycoprotein
67. T and Tn, general carcinoma antigens
68. Elevated expression of H type GDP-L-fucose:β-D-galactoside α-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression
69. Sialyl-Tn antigen as a useful predictor of poor prognosis in patients with advanced stomach cancer
70. Biosynthesis of rat MUC2 in colon and its analogy with human MUC2
71. O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer
72. Characterization of UDP-GlcNAc:GalNAc β3-N-acetylglucosaminyl-transferase activity from colonic tissues. Loss of the activity in human cancer cell lines
73. Sialyl-Tn antigen is an independent predictor of outcome in patients with gastric cancer
74. Sialosyl-Tn antigen as a marker of gastric cancer progression: An international study
75. A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans
76. Alterations of O-glycan biosynthesis in human colon-cancer tissues
77. Molecular cloning and expression of a novel β-1,6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches
78. Sialosyl-Tn antigen. Its distribution in normal human tissues and expression in adenocarcinomas