Sialyl Tn antigen is an independent predictor of outcome in patients with gastric cancer

International Journal of Cancer

Volumn 65, Issue 3, 1996, Pages 295-300

  Victorzon, Mikael ^a   Nordling, Stig ^a   Nilsson, Olle ^b   Roberts, Peter J ^a   Haglund, Caj ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Can Ag Diagnostics   (Sweden)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

SIALYL TN ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; STOMACH CANCER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0030029115     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960126)65:3<295::AID-IJC3>3.0.CO;2-V     Document Type: Article

References (23)

1. COX, D.R., Regression models and life tables. J. roy. statist. Soc., B34, 187-220 (1972).
2. DAVID, L., NESLAND, J.M., CLAUSEN, H., CARNEIRO, F. and SOBRINHO SIMOES, M., Simple mucin-type carbohydrate antigens (Tn, Siaiosyl-Tn and T) in gastric mucosa, carcinomas and metastases. APMIS suppl., 27, 162-172 (1992).
3. HAKOMORI, S., Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Advanc. Cancer Res., 52, 257-331 (1989).
4. IKEDA, Y., MORI, M., KAMAKURA, T., SAKU, M. and SUGIMACHI, K., Immunohistochemical expression of sialyl Tn and sialyl Lewis antigens in stromal tissue correlates with peritoneal dissemination in stage-IV human gastric cancer. Europ. J. surg. Oncol., 21, 168-175 (1995).
5. ITZKOWITZ, S.H., BLOOM, E.J., KOKAL, W.A., MODIN, G., HAKOMORI, S. and KIM, Y.S., Siaiosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer. 66, 1960-1966 (1990).
6. IWATA, H., ITZKOWITZ, S.H., WERTHER, J.L., HAYASHI, K., NAKAMURA, H., ICHINOSE, M., MIKI, K. and TATEMATSU, M., Expression of siaiosyl-Tn in intestinal type cancer cells of human gastric cancers. Acta pathol. jap., 43, 646-653 (1993).
7. KAKEJI, Y., MAEHARA, Y., MORITA, M., MATSUKAMA, A., FURUSAWA, M., TAKAHASHI, I., KUSUMOTO, T., OHNO, S. and SUGIMACHI, K., Correlation between siatyl Tn antigen and lymphatic metastases in patients with Borrmann type-IV gastric carcinoma. Brit. J. Cancer, 71, 191-195 (1995).
8. KJELDSEN, T., CLAUSES, H. and HIROHASHI, S., Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2-6a-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res., 48, 4361-4367 (1988).
9. KOBAYASHI, H., TERAO, T. and KAWASHIMA, Y., Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer. J. clin Oncol. 10, 95-101 (1992).
10. KUSHIMA, R., JANCIC, S. and HATTORI, T., Association between expression of sialosyl-Tn antigen and intestinalization of gastric carcinomas. Int. J. Cancer, 55, 904-908 (1993).
11. LAURÉN, P., The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinomas: an attempt at a histofogical classification. Acta pathol. rmcrobiol. scand., 64, 31-49 (1965).
12. LINDHOLM, L., HOLMGREN, J., SVENNERHOLM, L., FREDMAN, P., NILSSON, O., PERSSON, B., MYRVOLD, H. and LAGERGÀRD, T., Monoclonal antibodies against gastrointestinal tumour-associated antigens isolated as monosialogangliosides. Int. Arch. Allergy appl. Immunol, 71, 178-181 (1983).
13. MA, X.C., TERATA, N., KODAMA, M., JANCIC S., HOSOKAWA, Y. and HATTORI, T., Expression of siaiyl-Tn antigen is correlated with survival time of patients with gastric carcinomas. Europ. J. Cancer, 29a, 1820-1823 (1993).
14. MATSUKURA, N., SUZUKI, K., KAWACHI, T., AOYAGI, M., SUGIMURA, T., KITAOKA, H., NUMAJIRI, H., SHIROTA, A., ITABASHI, M. and HIROTA, T., Distribution of marker enzyme and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J. nat. Cancer Inst., 65, 231-240 (1980).
15. MILES, D., LINEHAN, J. and FILIPE, I., Expression of sialyl-Tn in gastric cancer: correlation with known prognostic factors. Brit. J. Cancer. 71, 1074-1076 (1995).
16. NAKASAKI, H., MITOMI, T., NOTO, T., OGOSHI, K., HANAUE, H., TANAKA, Y., MAKUUCHI, H., CLAUSEN, H. and HAKOMORI, S., Mosaicism in the expression of tumor-associated carbohydrate antigens in human colonic and gastric cancers. Cancer Res., 49, 3662-3669 (1989).
17. SPRINGER, G.F., T and Tn, general carcinoma autoantigens. Science (Wash.), 224, 1198-1206 (1984).
18. TAKAHASHI, I., MAEHARA, Y., KUSUMOTO, T., KOHNOE, S., KAKEJI, Y., BABA, H. and SUGIMACHI, K., Combined evaluation of preoperative serum siaiyl-Tn antigen and carcinoembryonic antigen levels is prognostic for gastric cancer patients. Brit. J. Cancer, 69, 163-166 (1994).
19. TAKAHASHI, I., MAEHARA, Y., KUSUMOTO, T., YOSHIDA, M., KAKEJI, Y., KUSUMOTO, H., FURUSAWA, M. and SUGIMACHI, K., Predictive value of preoperative serum sialyl Tn antigen levels in prognosis of patients with gastric cancer. Cancer, 72, 1836-1840 (1993).
20. UICC. TNM classification of malignant tumors, 4th ed. Springer, Berlin (1987).
21. WERTHER, J.L., RIVERA MACMURRAY, S., BRUCKNER, H., TATEMATSU, M. and ITZKOWITZ, S.H., Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome. Brit. J. Cancer. 69, 613-616 (1994).
22. YAMASHITA, Y., CHUNG, Y.S., HORIE, R., KANNAGI, R. and SOWA, M., Alterations in gastric mucin with malignant transformation: Novel pathway for mucin synthesis. J. nat. Cancer Inst., 87, 441-446 (1995).
23. YONEZAWA, S., TACHIKAWA, T., SHIN, S. and SATO, E., Siaiosyl-Tn antigen. Its distribution in normal human tissues and expression in adenocarcinomas. Amer. J. clin Paihol., 98, 167-174 (1992).