Cloning and expression of a human gene encoding an N-acetylgalactosamine-α2,6-sialyltransferase (ST6GalNAc I): A candidate for synthesis of cancer-associated sialyl-Tn antigens

Glycobiology

Volumn 9, Issue 11, 1999, Pages 1213-1224

  Ikehara, Yuzuru ^a,f   Kojima, Naoya ^b,g   Kurosawa, Nobuyuki ^b,h   Kudo, Takashi ^a   Kono, Mari ^a   Nishihara, Shoko ^a   Issiki, Soichiro ^a   Morozumi, Kyoei ^c   Itzkowitz, Steven ^d   Tsuda, Tetsuro ^e   Nishimura, Shin Ichiro ^e   Tsuji, Shuichi ^b   Narimatsu, Hisashi ^a  

^a SOKA UNIVERSITY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c Fussa Hospital   (Japan)

^d MOUNT SINAI MEDICAL CENTER   (United States)

^e HOKKAIDO UNIVERSITY   (Japan)

^f AICHI CANCER CENTER HOSPITAL   (Japan)

^g TOKAI UNIVERSITY   (Japan)

^h NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gastric cancer; Intestinal metaplasia; Sialyl Tn antigen; Sialyltransferase; ST6GalNAc

Indexed keywords

COMPLEMENTARY DNA; DNA FRAGMENT; RNA; SIALYLTRANSFERASE; SYNTHETASE; TUMOR ANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; CANCER PATIENT; COLORECTAL CANCER; ENZYME SPECIFICITY; GENE EXPRESSION; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTESTINE METAPLASIA; INTESTINE MUCOSA; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PYLORUS; SEQUENCE HOMOLOGY;

EUKARYOTA;

EID: 6544282655     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/9.11.1213     Document Type: Article

References (34)

1. Agrawal,B., Krantz,M.J., Reddish,M.A. and Longenecker,B.M. (1998) Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nature Med, 4, 43-49.
2. Brockhausen,I., Yang,J., Dickinson, N, Ogata,S. and Itzkowitz,S.H. (1998) Enzymatic basis for sialyl-Tn expression in human colon cancer cells. Glycoconj. J , 6, 595-603.
3. Chomczynski,P. and Sacchi,N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
4. Chou,P.Y. and Fasman,G.D. (1974) Prediction of protein conformation. Biochemistry, 13, 222-245.
5. Fukushi,Y., Nudelman,E., Levery,S.B., Hakomori,S. and Rauvala,H. (1984) Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucosanglioside (VI3NeuAcV3III3Fuc2nLc6). J. Biol Chem., 259, 10511-10517.
6. Harduin-Lepers,A., Recchi,M.A. and Delannoy,P. (1995) 1994, the year of sialyltransferases. Glycobiology, 5, 741-758.
7. Ikehara,Y., Nishihara,S., Kudo,T , Hiraga,N., Morozumi,K. and Narimatsu,H. (1998) The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression. Glycoconj, J., 15, 799-807.
8. Ishii,A., Ohta,M., Watanabe,Y., Matsuda,K , Ishiyama,K., Sakoe,K , Nakamura,M., Inokuchi, J., Sanai,Y. and Saito,M (1998) Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. J Biol Chem., 273, 31652-31655.
9. Itzkowitz,S.H., Bloom,E.J., Kokal,W.A., Modin,G., Hakomori,S. and Kim,Y.S. (1990) Sialosyl-Tn: a novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer, 66, 1960-1966.
10. Kjeldsen,T , Clausen,H., Hirohashi,S., Ogawa,T., Iijima,H. and Hakomori,S. (1988) Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2-6 α-N- acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res., 48, 2214-2220.
11. Kinney,A.Y., Sahin,A., Vemon,S.W., Frankowski,R.F., Annegers,J.F., Hortobagyi,G.N , Buzdar,A.U. and Frye,D.K. (1997) The prognostic significance of sialyl-Tn antigen in women treated with breast carcinoma treated with adjuvant chemotherapy. Cancer, 80, 2240-2249.
12. Kobayashi,H., Terao,T. and Kawashima,Y. (1992) Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer. J. Clin Oncol., 10, 95-101.
13. Kojima,N., Handa,K., Newman,W. and Hakomori,S. (1992) Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells. Biochem Biophys. Res Commun., 182, 1288-1295.
14. Kono, M., Takashima,S., Liu,H., Inoue,M., Kojima,N., Lee,Y.C., Hamamoto,T. and Tsuji,S. (1998) Molecular cloning and functional expression of a fifth-type α, 2,3- sialyltransferase (mST3Gal V: GM3 synthase). Biochem Biophys Res. Commun., 253, 170-175.
15. Kudo,T. and Narimatsu,H. (1995) The β,1,4-galactosyltransferase gene is post-transcriptionally regulated during differentiation of mouse F9 teratocarcinoma cells Glycobiology, 5, 397-403.
16. Kurosawa,N., Hamamoto,T , Lee,Y.C., Nakaoka,T., Kojima,N. and Tsuji,S. (1994a) Molecular cloning and expression of GalNAc α, 2,6-sialyltransferase. J Biol. Chem., 269, 1402-1409.
17. Kurosawa,N., Kojima,N., Inoue,M., Hamamoto,T. and Tsuji,S. (1994b) Cloning and expression of Gal β, 1,3GalNAc-specific GalNAc α, 2,6-sialyltransferase. J. Biol. Chem., 269, 19048-19053.
18. Kurosawa,N., Inoue,M., Yoshida,Y. and Tsuji,S. (1996) Molecular cloning and genomic analysis of mouse Galβ1, 3GalNAc-specific GalNAc α2,6-sialyltransferase. J. Biol. Chem , 271, 15109-15116.
19. Kurosawa,N., Yoshida,Y., Kojima,N. and Tsuji,S. (1997) Polysialic acid synthase (ST8Sia II/STX) mRNA expression in the developing mouse central nervous system. J. Neurochem., 69, 494-503.
20. Kushima,R., Jancic,S. and Hattori,T. (1993) Association between expression of sialosyl-Tn antigen and intestinalization of gastric carcinomas. Int. J. Cancer, 55, 904-908.
21. Kyte,J. and Doolittle,R.F. (1982) A simple method for displaying the hydropathic character of a protein. J Mol. Biol , 157, 105-132.
22. Lee,Y-C., Kaufmann,M., Kitazume-Kawaguchi,S., Kono.,M., Takashima,S., Kurosawa,N., Liu,H., Pircher,H. and Tsuji,S. (1999) Molecular cloning and functional expression of two members of mouse NeuAcα2,3Galβ1,3GalNAcα2,6-sialyltransferase family, ST6GalNAc III and IV. J. Biol. Chem , in press.
23. Ma,X.C., Terata,N., Kodama,M , Jancic,S., Hosokawa,Y. and Hattori T. (1993) Expression of sialyl-Tn antigen is correlated with survival time of patients with gastric carcinomas. Eur. J. Cancer, 29, 1820-1823.
24. Maemura,K and Fukuda,M. (1992) Poly-N-acetyllactosaminyl O-glycans attached to leukosialin. The presence of siaiyl Le (x) structures in O-glycans. J. Biol. Chem., 267, 24379-24386
25. Nakamori,S., Kameyama,M., Imaoka,S., Furukawa,H., Ishikawa,O., Sasaki,Y., Kabuto,T., Iwanaga,T., Matsushita,Y. and Irimura,T. (1993) Increased expression of sialyl Lewis x antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res , 53, 3632-3637.
26. Nakamori,S., Furukawa,H., Hiratsuka,M., Iwanaga,T., Imaoka,S., Ishikawa,O., Kabuto,T., Sasaki,Y., Kameyama,M., Ishiguro,S. and Irimura,T. (1997) Expression of carbohydrate antigen sialyl Le (a): a new functional prognostic factor in gastric cancer. J Clin. Oncol., 15, 816-825.
27. Nakayama,T., Watanabe,M., Katsumata,T., Teramoto,T. and Kitajima,M (1995) Expression of sialyl Lewis (a) as a new prognostic factor for patients with advanced colorectal carcinoma. Cancer, 75, 2051-2056.
28. Niwa,H., Yamarnura,K. and Miyazaki,J. (1991) Efficient selection for high-expression transfectants with a novel eukarvotic vector. Gene, 108, 193-199.
29. Rice,G.E. and Bevilacqua,M.P. (1989) An inducible endothelial cell surface glycoprotein mediates melanoma adhesion Science, 246, 1303-1306.
30. Sjoberg,E.R., Kitagawa,H., Glushka,J., van Halbeek,H. and Paulson,J.C. (1996) Molecular cloning of a developmentally regulated N-acetylgalactosamine α2,6-sialyltransferase specific for sialylated glycoconjugates. J. Biol Chem., 271, 7450-7459.
31. Soares,R., Marinho,A. and Schmitt,F. (1996) Expression of sialyl-Tn in breast cancer. Correlation with prognostic parameters. Pathol. Res. Pract., 192, 1181-1186.
32. Tsuji,S. (1996) Molecular cloning and functional analysis of sialyltransferases. J. Biochem. (Tokyo), 120, 1-13.
33. Werther,J.L., Rivera-MacMurray,S., Bruckner,H., Tatematsu,M. and Itzkowitz,S.H (1994) Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome. Br. J. Cancer, 69, 613-616
34. Werther,J.L., Tatematsu,M., Klein,R., Kurihara,M., Kumagai,K., Llorens,P., Guidugli Neto,J., Bodian,C., Pertsemlidis,D., Yamachika,T., Kitou,T. and Itzkowitz,S. (1996) Sialosyl-Tn antigen as a marker of gastric cancer progression: an international study. Int. J. Cancer, 69, 193-199.