MDR1 expression in poor-risk acute myeloid leukemia with partial or complete monosomy 7

Leukemia

Volumn 15, Issue 3, 2001, Pages 398-405

  Van Den Heuvel Eibrink, M M ^a   Wiemer, E A C ^a   De Boevere, M J ^a   Slater, R M ^a   Smit, E M E ^a   Van Noesel, M M ^a   Van Der Holt, B ^a   Schoester, M ^a   Pieters, R ^a   Sonneveld, P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Acute myeloid leukemia (AML); Chromosome 7 deletions; MDR1; Multidrug resistance (MDR); P glycoprotein (P gp)

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; CYTARABINE; DAUNORUBICIN; DNA HOMOLOG; GLYCOPROTEIN P; GUANINE; IDARUBICINE; MESSENGER RNA; MONOCLONAL ANTIBODY MRK 16; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE; THYMINE; UNCLASSIFIED DRUG; VALSPODAR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALLELE; ARTICLE; ASSAY; CANCER RISK; CANCER SURVIVAL; CHILD; CHROMOSOME 7Q; CHROMOSOME DELETION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; CYTOGENETICS; DNA METHYLATION; DNA POLYMORPHISM; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC CODE; HUMAN; INFANT; MOLECULAR PROBE; MONOSOMY 7; PARTIAL MONOSOMY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RIBONUCLEASE PROTECTION ASSAY; TRANSLATION REGULATION;

EID: 0035082694     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402027     Document Type: Article

References (46)

1. Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies
2. Multidrug resistance (MDR) genes in haematological malignancies
3. Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals
4. Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies
5. Structure and expression of the human MDR (P-glycoprotein) gene family
6. Structure of the human MDR3 gene and physical mapping of the human MDR locus
7. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
8. Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry
9. Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors
10. Multiple-drug resistance in human cancer
11. Resistance to multiple chemotherapeutic agents in human cancer cells
12. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
13. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines
14. Overexpression of a M(r) 110,000 vesicular protein in non-P- glycoprotein-mediated multidrug resistance
15. Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia
16. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia
17. MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukemia
18. P-glycoprotein expression and prognostic value in acute myeloid leukemia
19. Both P-gp and MRP contribute to drug resistance in AML
20. P-glycoprotein, lung resistance-related protein and multidrug resistance associated protein in de novo acute non-lymphocytic leukaemias: Biological and clinical implications
21. Clinical relevance of P-glycoprotein expression in de novo acute myeloid leukemia
22. Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy
23. Molecular characterization of the 7q deletion in myeloid disorders
24. Delineation of genomic regions in chromosome band 7q22 commonly deleted in myeloid leukemias
25. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
26. Proposed revised criteria for the classification of acute myeloid leukemia
27. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples
28. Identification of two distinct regulatory regions adjacent to the human beta-interferon gene
29. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
30. Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24
31. Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine
32. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells
33. Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias
34. Interphase cytogenetics reveals somatic pairing of chromosome 17 centromeres in normal human brain tissue, but no trisomy 7 or sex-chromosome loss
35. Gene rearrangement: A novel mechanism for MDR-1 gene activation
36. Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
37. Specific enzymatic amplification of DNA in vitro: The polymerase chain reaction
38. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
39. Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual
40. From genotypes to genes: Doubling the sample size
41. Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26)
42. P-glycoprotein (PGP) and lung resistance-related protein (LRP) expression and function in leukaemic blast cells
43. DNA methylation
44. Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells
45. Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance