P-glycoprotein (PGP) and lung resistance-related protein (LRP) expression and function in leukaemic blast cells

British Journal of Haematology

Volumn 96, Issue 2, 1997, Pages 356-365

  Michieli, Mariagrazia ^a,d   Damiani, Daniela ^a   Ermacora, Anna ^a   Raspadori, Donatella ^b   Michelutti, Angela ^a   Grimaz, Stefania ^a   Fanin, Renato ^a   Russo, Domenico ^a   Lauria, Francesco ^c   Masolini, Paola ^a   Baccarani, Michele ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d UNIVERSITY HOSPITAL OF UDINE   (Italy)

Author keywords

leukaemia; lung resistance related protein (LRP); multidrug resistance (MDR); multidrug resistance associated protein (MRP); P glycoprotein (PGP)

Indexed keywords

DAUNORUBICIN; GLYCOPROTEIN P; LUNG RESISTANCE PROTEIN; RHODAMINE 123; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLAST CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA; MAJOR CLINICAL STUDY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 8044247207     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2020.x     Document Type: Article

References (57)

1. Abbaszadegan, M.R., Futscher, B.W., Klimecki, W.T., List, A. & Dalton, W.S. (1994) Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells. Cancer Research, 54, 4676-4679.
2. Barrand, M.A., Rhodes, T., Center, M.S. & Twentyman, P.R. (1993) Chemosensitisation and drug accumulation effects of Cyclosporin A, PSC-833 and Verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein. European Journal of Cancer, 29A, 408-415.
3. Broxterman, H.J. (1994) How to probe clinical specimens for MDR. 1st International Conference on Reversal of Multidrug Resistance in Cancer, St Gallen, Switzerland, 1-3 September.
4. Broxterman, H.J., Sonneveld, P., Feller, N., Ossenkoppele, G.J., Währer, D.C.R., Eekman, C.A., Schoester, M., Lankelma, J., Pinedo, H.M., Löwenberg, B. & Schuurhuis, G.J. (1996) Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity. Blood, 87, 4809-4816.
5. Campos, L., Guyotat, D, Archlmbaud, E., Calmard-Oriol, P., Tsuruo, T., Troncy, J., Treille, D. & Fiere, D. (1992a) Clinical significance of multidrug resistance P-glycoprotein expression on acute non-lymphoblastic leukemia cells at diagnosis. Blood, 79, 473-476.
6. Campos, L., Guyotat, D., Jaffar, C., Solary, E., Archimbaud, E. & Treille, D. (1992b) Correlation of MDR1/P-170 expression with daunorubicin uptake and sensitivity of leukemic progenitors in acute myeloid leukemia. European Journal of Haematology, 48, 254-258.
7. Chin, J.E., Soffir, R., Noonan, K.E., Choi, K. & Roninson, I.B. (1989) Structure and expression of the human MDR (P-glycoprotein) gene family. Molecular and Cellular Biology, 9, 3808-3820.
8. Choi, K., Frommel, T.O., Stern, R.K., Perez, C.F., Kriegler, M., Tsuruo, T. & Roninson, I.B. (1991) Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proceedings of the National Academy of Sciences of the United States of America, 88, 7386-7390.
9. Cole, S.P.C., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., Stewart, A.J., Kurz, E.U., Duncan, A.M.V. & Deeley, R.G. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science, 258, 1650-1656.
10. Cole, S.P.C., Sparks, K.E., Fraser, K., Loe, D.W., Grant, C.E., Wilson, G.M. & Deeley, R.G. (1994) Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Research, 54, 5902-5910.
11. Cumber, P.M., Jacobs, A., Hoy, T., Fisher, J., Whittaker, J.A., Tsuruo, T. & Padua, R.A. (1990) Expression of the multiple drug resistance gene (mdr-1 ) and epitope masking in chronic lymphatic leukaemia. British Journal of Haematology, 76, 226-230.
12. Damiani, D., Michieli, M., Michelutti, A., Fanin, R., Russo, D. & Baccarani, M. (1995) P170 glycoprotein expression and impaired anthracycline retention in chronic myeloid leukemia. Leukemia and Lymphoma, 17, 289-294.
13. Damiani, D., Michieli, M., Michelutti, A., Geromin, A., Raspadori. D., Fanin, R., Savignano, C., Giacca, M., Pileri, S., Mallardi, F. & Baccarani, M. (1993) Expression of multidrug resistance gene (mdr-1) in human normal leukocytes. Haematologica, 78, 12-17.
14. Flens, M.J., Izquierdo, M.A., Scheffer G.L., Fritz, J.M., Meijer, J.L.M., Scheper. R.J. & Zaman, G.J.R. (1994) Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Research, 54, 4557-4563.
15. Ford, J.M. & Hait, W.N. (1990) Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacological Reviews, 42, 155-199.
16. Grant, CE., Valdimarsson, G., Hipfner, D.R., Almquist, K.C., Cole, S.P.C. & Deeley, R.G. (1994) Over-expression of multidrug-associated protein (MRP) increases resistance to natural product drugs. Cancer Research, 54, 357-361.
17. Guerci, A., Merlin, J.L., Missoum, N., Feldmann, L., Marchai, S., Witz, F., Rose, C. & Guerci, O. (1995) Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry. Blood, 85, 2147-2155.
18. Haber, D.A. (1992) Multidrug resistance (MDR1) in leukemia: is it time to test? Blood, 79, 295-296.
19. Hart, S.M., Ganeshaguru, K., Hoffbrand, A.V., Prentice, H.C. & Mehta, A.B. (1994) Expression of the multidrug resistance-associated protein (MRP) in acute leukemia. Leukemia, 8, 2163-2168.
20. Hart, S.M., Ganeshaguru, K., Scheper, R.J., Hoffbrand, A.V. & Mehta, A.B. (1993) Expression of the human major vault protein LRP in haematological malignancy. Thirty-fifth Annual Meeting of the American Society of Hemalology. St Louis, Mo., 3-7 December, Abstract 146.
21. Ino, T., Miyazaki, H., Isogai, M., Nomura, T., Tsuzuki, M., Tsuruo, T., Ezaki, K. & Hirano, M. (1994) Expression of P-glycoprotein in de novo acute myelogenous leukemia at initial diagnosis: results of molecular and functional assays, and correlation with treatment outcome. Leukemia, 8, 1492-1499
22. Kato, S., Ideguchi, H., Muta, K., Nishimura, J. & Nawata, H. (1991) Absence of correlation between cytotoxicity and drug transport by P-glycoprotein in clinical leukemic cells. European Journal of Haematoloay, 47, 146-151.
23. Kedersha, N.L. & Rome, L.H. (1986) Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA. Journal of Cell Biology 103, 699-709.
24. Kuiper, C.M., Broxterman, H.J., Baas, F., Schuurhuis, G.J., Haisma, H.J., Scheffer, G.L., Lankelma, J. & Pinedo, H.M. (1990) Drug transport variant without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin. Journal of Cell Pharmacology 1, 35-41.
25. Lamy, T., Drenou, B., Grulois, I., Fardel, O., Jacquelinet, C., Goasguen, J., Dauriac, C., Amiot, L., Bernard, M., Fauchet, R. & Le Prise, A. (1995) Multidrug resistance (MDR) activity in acute leukemia determined by rhodamine 123 efflux assay. Leukemia, 9, 1549-1555.
26. Lehne, G., De Angelis, P., Clausen, O.P.F., Egeland, T., Tsuruo, T. & Rugstad, H.E. (1995) Binding diversity of antibodies against external and internal epitopes of the multidrug resistance gene product P-glycoprotein. Cytometry, 20, 228-237.
27. - cases. Blood, 86, 2329-2342.
28. List, A.F., Spier, C.S., Grogan, T.M., Johnson, C., Roe, D.J., Greer, J.P., Wolff, S.N., Broxterman, H.J., Scheffer, G.L., Scheper, R.J. & Dalton, W.S. (1996) Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood, 87, 2464-2469.
29. Luk, C.K. & Tannock, I.F. (1989) Flow cytometric analysis of doxorubicin accumulation in cells from human and rodent cell lines. Journal of the National Cancer Institute, 81, 55-59.
30. Marie, J.P., Faussat-Suberville, A.M., Zhou, D. & Zittoun, R. (1993) Daunorubicin uptake by leukemic cells: correlation with treatment outcome and mdr1 expression. Leukemia, 7, 825-831.
31. Marie, J.P., Zittoun, R. & Sikic, B.I. (1991) Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlation with treatment outcome and in vitro drug sensitivity. Blood, 78, 586-592.
32. Michieli, M., Damiani, D., Geromin, A., Michelutti, A., Fanin, R., Raspadori, D., Russo, D., Visani, G., Dinota, A., Pileri, S., Tsuruo, T., Grandi, M., Baccarani, M. & Tura, S. (1992) Over-expression of multidrug resistance-associated p 170-glycoprotein in acute non-lymphocytic leukemia. European Journal of Haematalogy, 48, 87-92.
33. Michieli, M., Damiani, D., Michelutti, A., Grimaz, S., Geromin, A., Fanin, R., Russo, D., Masolini, P. & Baccarani, M. (1996) Screening for multidrug resistance in leukemia: cell reactivity to MRK-16 correlates with anthracycline retention and sensitivity of leukemic cells. Leukemia and Lymphoma, 18, 179-184.
34. Michieli, M., Damiani, D., Michelutti, A., Melli, C., Russo, D., Fanin, R. & Baccarani, M. (1994) P170-dependent multidrug resistance: restoring full sensitivity to idarubicin with verapamil and cyclosporin A derivatives. Haematolagica, 79, 119-126.
35. Murphy, L.D., Herzog, C.E., Rudick, J.B., Fojo, A.T. & Bates, S.E. (1990) Use of polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochemistry, 29, 10351-10356.
36. Paietta, E., Andersen, J., Racevskis, J., Ashigbi, M., Cassileth, P. & Wiernik, P.H., and the Eastern Cooperative Oncology Group (1995) Modulation of multidrug resistance in de novo adult acute myeloid leukemia: variable efficacy of reverting agents in vitro. Blood Reviews, 9, 47-52.
37. Pileri, S.A., Sabattini, E., Falini, B., Tazzari, P.L., Gherlinzoni, F., Michieli, M.G., Damiani, D., Zucchini, L., Gobbi, M., Tsuruo, T. & Baccarani, M. (1991) Immunohistochemical detection of the multidrug transport protein P170 in human normal tissues and malignant lymphomas. Histopathology, 19, 131-140.
38. Rome, L.H., Kedersha, N.L. & Chugani, D.C. (1991) Unlocking vaults: organelles in search of a function. Trends in Cell Biology, 1, 47.
39. Ross, D.D., Doyle, L.A., Schiffer, C.A., Lee, E.J., Grant, C.E., Cole, S.P.C., Deeley, R.G., Yang, W. & Tong, Y (1996) Expression of multidrug resistance-associated protein (MRP) mRNA in blast cells from acute myeloid leukemia (AML) patients. Leukemia, 10, 48-55.
40. Ross, D.D., Wooten, P.J., Sridhara, R., Ordoñez, J.V., Lee, E.J. & Schiffer, C.A. (1993) Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia. Blood, 82, 1288-1299.
41. Scheffer. G.L., Wijngaard, P.L.J., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., Meijer, C.J.L.M., Clevers, H.C. & Scheper, R.J. (1995) The drug resistance-related protein LRP is the human major vault protein. Nature Medicine, 1, 578-582.
42. Scheper, R.J., Broxterman, H.J., Scheffer, G.L., Kaaijk, P., Dalton, W.S., van Heijningen T.H.M., van Kalken, G.K. Slovak, M.L., de Vries, E.G.E., van der Valk, P., Meijer, C.J.L.M. & Pinedo, H.M. (1993) Over-expression of a Mr 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Research, 53, 1475-1479.
43. Schneider, E., Cowan, K.H., Bader, H., Toomey, S., Schwartz, G.N., Karp, J.E., Burke, P.J. & Kaufmann, S.H. (1995) Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia. Blood, 85, 186-193.
44. Schneider, E., Horton, J.K., Yang, C.H., Nakagawa, M. & Cowan, K.H. (1994) Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Research, 54, 152-158.
45. Schuurhuis, G.J., Broxterman, H.J., de Lange, J.H.M., Pinedo, H.M., van Heijningen, T.H.M., Kuiper, C.M., Scheffer, G.L., Scheper, R.J., van Kalken, C.K., Baak, J.P.A. & Lankelma, J. (1991) Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein. British Journal of Cancer, 64, 857-861.
46. Schuurhuis, G.J., Broxterman, H.J., Ossenkoppele, G.J., Baak, J.P.A., Eekman, C.A., Kuiper, C.M., Feller, N., van Heijningen, T.H.M., Klumper. E., Pieters, R., Lankelma, J. & Pinedo, H.M. (1995) Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-β-D-arabinofuranosylcytosine sensitivity may predict response in acute myeloid leukemia. Clinical Cancer Research, 1, 81-93.
47. te Boekhorst P.A.W.. Löwenberg, B., van Kapel, J., Nooter, K. & Sonneveld, P. (1995) Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia. Leukemia, 9, 1025-1031.
48. Tsuruo, T. (1988) Mechanisms of multidrug resistance and implications for therapy. Japanese Journal of Cancer Research, 79, 285-296.
49. van der Graaf, W.T.A., de Vries, E.G.E., Timmer-Bosscha, H., Meersma, G.J., Mesander, G., Vellenga, E. & Mulder, N.H. (1994) Effects of amiodarone, cyclosporin A, and PSC 833 on the cytotoxicity of mitoxantrone, doxorubicin, and vincristine in non-P-glycoprotein human small cell lung cancer cell lines. Cancer Research, 54, 5368-5373.
50. Versantvoort, C.H.M., Schuurhuis, G.J., Pinedo, H.M., Eekman, C.A., Kuiper, C.M., Lankelma, J. & Broxterman, H.J. (1993) Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. British Journal of Cancer, 68, 939-946.
51. 4 sublines with increasing adriamycin resistance. International Journal of Cancer, 61, 375-380.
52. Weinstein, R.S., Kuszak, J.R., Kluskens, L.F. & Coon, J.S. (1990) P-glycoprotein in pathology: the multidrug resistance gene family in humans. Human Pathology, 21, 34-48.
53. Wood, P., Burgess, R., MacGregor, A. & Liu Yin, J.A. (1994) P-glycoprotein expression on acute myeloid leukaemia blast cells at diagnosis predicts response to chemotherapy and survival. British Journal of Haematology, 87, 509-513.
54. Xie, X.Y., Robb, D., Chow, S. & Hedley, D.W. (1995) Discordant P-glycoprotein antigen expression and transport function in acute myeloid leukemia. Leukemia, 9, 1882-1887.
55. Zaman, G.J.R., Versantvoort, C.H.M., Smit, J.J.M., Eijdems, E.W.H.M., de Haas, M., Smith, A.J., Broxterman, H.J., Mulder, N.H., de Vries, E.G.E., Baas, F. & Borts, P. (1993). Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Research, 53, 1747-1750.
56. Zöchbauer, S., Gsur, A., Brunner, R., Kyrie, P.A., Lechner, K. & Pirker, R. (1994) P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia. Leukemia, 8, 974-977.
57. Zhou D.C., Zittoun, R. & Marie, J.P. (1995) Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukemia. Leukemia, 9, 1661-1666.