Resistance of activated human Th2 cells to NO-induced apoptosis is mediated by γ-glutamyltranspeptidase

International Immunology

Volumn 13, Issue 4, 2001, Pages 519-528

  Roozendaa, Ramon ^a   Vellenga, Edo ^a   De Jong, Marian A ^a   Traanberg, Kristine F ^a   Postma, Dirkje S ^a   De Monchy, Jan G R ^a   Kauffman, Henk F ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Apoptosis; Differentiation; Glutathione; NO; T lymphocyte; Th2 skewing; Glutamyltranspeptidase

Indexed keywords

ANNEXIN; CD4 ANTIGEN; CD45 ANTIGEN; CYTOKINE ANTIBODY; ENZYME INHIBITOR; FAS ANTIGEN; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; INTERLEUKIN 12; INTERLEUKIN 4; NITRIC OXIDE; NITRIC OXIDE DONOR; PENTETIC ACID; SPERMINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL POLARITY; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATORY CELL; LYMPHOCYTE CULTURE; NORMAL HUMAN; PRIORITY JOURNAL; STAINING; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 0035073050     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.4.519     Document Type: Article

References (43)

1. Cellular environments and apoptosis: Tissue microenvironments control activated T-cell death
2. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis
3. h2, effectors undergo rapid Fas/FasL-mediated apoptosis
4. h2 T cells to express Fas ligand and to undergo activation-induced cell death
5. Differential ability of T cell subsets to undergo activation-induced cell dealth
6. Nitric oxide in autoimmune disease: Cytotoxic or regulatory mediator?
7. h2 cells
8. Altered immune responses in mice lacking inducible nitric oxide synthase
9. Nitric oxide induces and inhibits apoptosis through different pathways
10. Nitric oxide as a bifunctional regulator of apoptosis
11. Nitric oxide selectively decreases interferon-γ expression by acticvated human T lymphocytes via a cGMP-independent mechanism
12. Activation of the cAMP-dependent signaling pathway downregulates the expression o interleukin-3 and granulocyte-macrophage colony-stimulating factor in activated human T lymphocytes
13. Detection of intracellular cytokines by flow cytometry
14. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
15. Flow cytometric analysis of mitochondrial activity in situ: Application to acetylceramide-induced mitochondrial swelling and apoptosis
16. Nitric oxide synthase plays a signaling role in TCR-triggered apoptotic death
17. c0 CD8 T-cell clones display distinct cell surface and functional phenotypes
18. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
19. + peripheral blood cells
20. Selective expressionof the eotaxin receptor CCR3 by human T helper 2 cells
21. Caspase activation is required for nitric oxide-mediated, CD95(APO-1/Fas)-dependent and independent apoptosis in human neoplastic lymphoid cells
22. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils
23. Reactive oxygen species regulate activation-induced T cell apoptosis
24. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells
25. Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP2
26. h1 cells
27. Nitric oxide and asthmatic inflammation
28. Nitric oxide (NO) donor molecules: Effect of NO release rate on vascular smooth muscle cell proliferation in vitro
29. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds
30. Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release
31. h2 resistance from Fas-mediated apoptosis
32. Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes
33. Evidence that the γ-glutamyl cycle functions in vivo using intracellular glutathione: Effects of amino acids and selective inhibition of enzymes
34. S-Nitrosoglutathione as a substrate for γ-glutamyl transpeptidase
35. The ectoenzyme γ-glutamyl transpeptidase regulates anti-proliferative effects of S-nitrosoglutathione on human T and B lymphocytes
36. The level and half-life of glutathione in human plasma
37. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition
38. Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms
39. h1 cell development through the inhibition of IL-12 synthesis by macrophages
40. The ectoenzyme γ-glutamyltranspeptidase regulates antiproliferative effects of S-nitrosogluthione on human T and B lymphocytes
41. BCL-2 and glutathione: Alterations in cellular redox state that regulate apoptotic sensitivity
42. The role of glutathione in the regulation of apoptosis
43. Glutathione is a factor of resistance of Jurkat leukemia cells to nitric oxide-mediated apoptosis