The immuno-inflammatory reaction in Crohn's disease and ulcerative colitis: Characterisation, genetics and clinical application. Focus on TNFα

Acta Gastro-Enterologica Belgica

Volumn 64, Issue 1, 2001, Pages 1-5

  Louis, E ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Genetics; Inflammation; Inflammatory bowel disease; Tumour necrosis factor

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BELGIUM; COLON CROHN DISEASE; COLON MUCOSA; DNA POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; ULCERATIVE COLITIS;

BIOLOGICAL MARKERS; COLITIS, ULCERATIVE; CROHN DISEASE; HUMANS; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; POLYMORPHISM, GENETIC; RECEPTORS, INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035070745     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Increased production of stromelysin-1 (MMP-3) and tissue inhibitor of metalloproteinase-1 (TIMP-1) by inflamed mucosa in inflammatory bowel disease
2. Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease
3. Bronchial eosinophilic infiltration in Crohn's disease in the absence of pulmonary disease
4. Cytokine gene polymorphisms in inflammatory bowel disease
5. TNF gene polymorphism in Crohn's disease (CD): Influence on disease behaviour?
6. Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
7. Genetic markers may predict disease behavior in patients with ulcerative colitis
8. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
9. Soluble interleukin-2 receptor in Crohn's disease. Assessment of disease activity and prediction of relapse
10. A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn's disease
11. Tumor necrosis factor: Biology and therapeutic inhibitors
12. Tumor necrosis factor-α, interleukin-1β, and interleukin-6 expression in inflammatory bowel disease
13. Quantitative PCR analysis of TNFα and IL-1β mRNA levels in pediatric IBD mucosal biopsies
14. Enhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
15. A major role for matrix metalloproteinases in T cell injury in the gut
16. Suppression of cell-mediated injury in human gut by interleukin 10: Role of matrix metalloproteinases
17. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNFα and TNFβ by human mononuclear cells: A possible link to insulin-dependent diabetes mellitus
18. DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/Lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin gene
19. Effects of a polymorphism in the human tumor necrosis factor a promoter on transcriptional activation
20. Secretion of tumor necrosis factor α and lymphotoxin in relation to polymorphism in the TNF genes ans HLA-DR alleles. Relevance for inflammatory bowel disease
21. Direct stimulation of cytokines (IL-1 beta, TNF alpha, IL-6, IL-2, IFN gamma and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation
22. Tumor necrosis factor a decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: Potential regulation of the glucocorticoid receptor
23. TNF-308 genotype or serum TNFα levels have no predictive value for response to infliximab treatment in Crohn's disease