Brn-3a activates the expression of Bcl-xL and promotes neuronal survival in vivo as well as in vitro

Molecular and Cellular Neuroscience

Volumn 17, Issue 3, 2001, Pages 460-470

  Smith, Martin D ^a   Melton, Lisa A ^a   Ensor, Elizabeth A ^a   Packham, Graham ^b   Anderson, Patrick ^c   Kinloch, Ross A ^d   Latchman, David S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL X; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU4F1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FATE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE EXPRESSION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCIATIC NEUROPATHY; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035068711     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0927     Document Type: Article

References (49)

1. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
2. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
3. P53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU domain transcription factor
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. Safe delivery of a trans-gene to the mouse central or peripheral nervous system using HSV1 ICP34.5 deletion mutant vectors
6. The Brn-3a transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis
7. Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors
8. Brn-3.0: A POU domain protein expressed in sensory immune and endocrine systems that functions on elements distinct from known octamer motifs
9. Bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria
10. Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
11. Mitochondria and apoptosis
12. Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons. I. Sympathetic neurons
13. Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons. II. Sensory neurons
14. Role of BCL-2 in the survival and function of developing and mature sympathetic neurons
15. Bcl-2 family members and the mitochondria in apoptosis
16. Expression of a large family of POU-domain regulatory genes in mammalian brain development
17. Death of some dorsal root gangion neurons and plasticity of others following sciatic nerve section in adult and neonatal rats
18. Amplification of RNA
19. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
20. Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
21. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells
22. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
23. Gentically defined roles of class I, class III, and class IV POU domain factors in the development of the mammalian endocrine and nervous systems
24. Optimisation of liposome mediated transfection of a neuronal cell line
25. Bcl-x(S) antagonizes the protective effects of Bcl-x(L)
26. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
27. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
28. Ultrastructural localization of Bcl-2 protein
29. Massive cell death of immature haematopoetic cells and neurons in Bcl-x-deficient mice
30. Targeted disruption of Bcl-2 in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
31. A novel Brn-3 like POU transcription factor in subsets of rat sensory and spinal cord neurons
32. Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system
33. Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury
34. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
35. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
36. The Brn-3a transcription factor induces neuronal process outgrowth and the co-ordinate expression of genes encoding synaptic proteins
37. Inhibition of neuronal process outgrowth and neuronal specific gene expression by the Brn-3b transcription factor
38. Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU domain transcription factor
39. The N-terminal activation domain unique to the long form of the Brn-3a transcription factor is essential to protect neurons from apoptosis and for the activation of Bcl-2 gene expression
40. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
41. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
42. Developmental regulation of apoptosis in dorsal root ganglion neurons
43. Bcl-2 targets the protein kinase Raf-1 to mitochondria
44. Novel cell lines display properties of nociceptive neurons
45. NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons
46. Brn-3b: A POU domain gene expressed in a subset of retinal ganglion cells
47. The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in the dorsal root ganglion
48. Molecular control of life and death