Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons

Neuropharmacology

Volumn 37, Issue 7, 1998, Pages 905-918

  Mongeau, Raymond ^a   Weiss, Michel ^a   De Montigny, Claude ^a   Blier, Pierre ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

5 HT neurons; Dorsal raphe; Locus coeruleus; Milnacipran; NE neurons

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CITALOPRAM; MILNACIPRAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; DRUG EFFECT; HYPOTHALAMUS; LOCUS CERULEUS; MALE; NONHUMAN; NORADRENERGIC NERVE; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE; SUBCUTANEOUS DRUG ADMINISTRATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BIOLOGICAL TRANSPORT; CLONIDINE; CYCLOPROPANES; DESIPRAMINE; DRUG ADMINISTRATION SCHEDULE; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; HYPOTHALAMUS; INJECTIONS, SUBCUTANEOUS; KINETICS; LOCUS COERULEUS; LYSERGIC ACID DIETHYLAMIDE; MALE; MESENCEPHALON; NEURONS; NOREPINEPHRINE; QUINOXALINES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SPIPERONE; TIME FACTORS;

EID: 0031926746     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00083-5     Document Type: Article

References (42)

1. Aghajanian, G.K., 1978. Feedback regulation of central monoaminergic neurons: evidence from single cell recording studies. In: Youdim M.B.H., Lovenberg W., Sharman D.F., Lagnado J.R. (Eds.), Essays in Neurochemistry and Neuropharmacology. Wiley, New York, pp. 1-32.
2. Anderson, C., Pasquier, D., Forbes, W., Morgane, P., 1977. Locus coeruleus-to-dorsal raphe input examined by electrophysiological and morphological methods. Brain Res. Bull. 2, 209-221.
3. Assie, M.B., Charveron, M., Palmier, C., Puozzo, C., Moret, C., Briley, M., 1992. Effects of prolonged administration of milnacipran, a new antidepressant, on receptors and monoamine uptake in the brain of the rat. Neuropharmacology 31, 149-155.
4. Baraban, J.M., Aghajanian, G.K., 1980. Suppression of firing activity of 5-HT neurons in the dorsal raphe by α-adrenoceptor antagonists. Neuropharmacology 19, 355-363.
5. Baraban, J.M., Aghajanian, G.K., 1981a. Suppression of serotonergic neuronal firing by α-adrenoceptor antagonists: evidence against GABA mediation. Eur. J. Pharmacol. 66, 287-294.
6. Blier, P., de Montigny, C., 1980. Effect of chronic tricyclic antidepressant treatment on the serotoninergic autoreceptor: a microiontophoretic study in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 314, 123-128.
7. Blier, P., de Montigny, C., 1983. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J. Neurosci. 3, 1270-1278.
8. Blier, P., de Montigny, C., 1985. Serotonergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors. Neuroscience 16, 949.
9. 1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1, 470-480.
10. Blier, P., de Montigny, C., 1994. Current advances and trends in the treatment of depression. Trends Pharmacol. Sci. 15, 220-226.
11. Blier, P., de Montigny, C., Tardif, D., 1984. Effects of the two antidepressant drugs niianserin and indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology 84, 242-249.
12. Blier, P., de Montigny, C., Azzaro, A., 1986. Effect of repeated amiflamine administration on serotonergic and noradrenergic neurotransmission: Electrophysiological studies in the rat CNS. Naunyn-Schmiedeberg's Arch. Pharmacol. 334, 253-260.
13. Blier, P., Lista, A., de Montigny, C., 1993. Differential properties of pre- and postsynaptic 5-hydroxytryptamine 1A receptors in the dorsal raphe and hippocampus: effect of spiperone. J. Pharmacol. Exp. Ther. 265, 7-15.
14. 2-adrenoceptors to the imidazoline preferring receptors. Fundam. Clin. Pharmacol. 6 (Suppl. 1), 15s-21s.
15. Chaput, Y., de Montigny, C., Blier, P., 1986. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 333, 342-348.
16. Christie, M.J., Williams, J.T., North, R.A., 1987. Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol. Pharmacol. 32, 633-638.
17. Frankhuijzen, A.L., Wardeh, G., Hogenboom, F., Mulder, A.H., 1988. Alpha-2 adrenoceptor mediated inhibition of the release of radiolabelled 5-hydroxytryptamine and noradrenaline from slices of the dorsal region of the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 337, 255-260.
18. 2-adrenoceptors on rat central neurons. Eur. J. Pharmacol. 105, 265-272.
19. Garratt, J.C., Crespi, F., Mason, R., Marsden, C.A., 1991. Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function. Eur. J. Pharmacol. 193, 87-93.
20. Haddjeri, N., de Montigny, C., Curet, O., Blier, P., 1998. Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. Eur. J. Pharmacol. 343, 179-192.
21. 2-adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. J. Pharmacol. Exp. Ther. 277, 861-871.
22. Huang, Y.H., Maas, J.W., Hu, G.H., 1980. The time course of noradrenergic pre- and postsynaptic activity during chronic desipramine treatment. Eur. J. Pharmacol. 68, 4147.
23. Hyttel, J., 1982. Citalopram - Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 6, 277-295.
24. Kasper, S., Pletan, Y., Solles, A., Tournoux, A., 1996. Comparative studies with milnacipran and tricyclic antidepressants in the treatment of patients with major depression a summary of clinical trial results. Int. Clin. Psychopharmacol. 11 (suppl. 4), 35-40.
25. Lacroix, D., Blier, P., Curet, O., de Montigny, C., 1991. Effects of long-term desipramine administration on noradrenergic neurotransmission reuptake: electrophysiological studies in the rat brain. J. Pharmacol. Exp. Ther. 257, 1081-1090.
26. Lecrubier, Y., Pletan, Y., Solles, A., Tournoux, A., Magne, V., 1996. Clinical efficacy of minacipran: placebo-controlled trials. Int. Clin. Psychopharmacol. 11 (suppl. 4), 29-34.
27. Lopez-Ibor, J., Guelfi, J.D., Pletan, A., Tournoux, A., Prost, J.F., 1996. Milnacipran and selective serotonin reuptake inhibitors in major depression. Int. Clin. Psychopharmacol. 11 (suppl. 4), 41-46.
28. Macher, J.P., Schel, J.P., Serre, C., Von Frenckell, R., Huck, J.C., Demarez, J.P., 1989. Double-blind placebo-controlled study of minalcipran in hospitalized patients with major depressive disorders. Neuropsychobiology 22, 77-82.
29. McMillen, B.A., Warnack, W., German, D.C., Shore, P.A., 1980. Effects of chronic desipramine treatment on rat brain noradrenergic responses to α-adrenergic drugs. Eur. J. Pharmacol. 61, 239-246.
30. 2-autoreceptor sensitivity. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 18, 1063-1072.
31. Moret, C., Charveron, M., Finberg, J.P.M., Couzinier, J.P., Briley, M., 1985. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24, 1211-1219.
32. Moret, C., Briley, M., 1996. Milnacipran, a double noradrenaline and 5-HT reuptake inhibiting antidepressant increases cerebral extracellular monoamine levels. Eur. Neuropsychopharmacol. 6 (suppl. 4), 68.
33. Palmier, C., Puozzo, C., Lenehan, T., Briley, M., 1989. Monoamine uptake inhibition by plasma from healthy volunteers attenuated by single oral doses of the antidepressant milnacipran. Eur. J. Clin. Pharmacol. 37, 235-238.
34. Sakai, K., Salvert, D., Touret, M., Jouvet, M., 1977. Afferent connections of the raphe dorsalis in the cat as visualized by the horseradish peroxidase technique. Brain Res. 137, 11-35.
35. Scuvée-Moreau, J.J., Dresse, A., 1979. Effect of various antidepressant drugs on the spontaneous firing rate of locus coeruleus and dorsal raphe neurons of the rat. Eur. J. Pharmacol. 57, 219-225.
36. 2- and opiate receptors after chronic treatment with various antidepressants. J. Neural Transm. 54, 51.
37. Svensson, T.H., Bunney, B.S., Aghajanian, G.K., 1975. Inhibition of both noradrenaline and serotonin neurons in brain by the α- adrenergic agonist clonidine. Brain Res. 92, 291-306.
38. Szabo, B., Fröhlich, R., Illes, P., 1996. No evidence for functional imidazoline receptors on locus coeruleus neurons. Naunyn-Schmiedeberg's Arch. Pharmacol. 353, 557-563.
39. Unnerstall, J.R., Fernandez, T., Orensanz, L.M., 1985. The α-adrenergic receptor: radiohistochemical analysis of functional characteristics and biochemical differences. Pharmacol. Biochem. Behav. 22, 859-874.
40. Valentine, R.J., Curtis, A.L., Parris, D.G., Wehby, R.G., 1990. Antidepressant actions on brain noradrenergic neurons. J. Pharmacol. Exp. Ther. 253, 833-840.
41. Vergé, D., Daval, G., Marcinkiewicz, M., Patey, A., el Mestikawy, S., Gozlan, H., Hamon, M., 1986. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6, 3474-3482.
42. Von Frenckell, R., Ansseau, M., Serre, C., Sutet, P., 1990. Pooling two controlled comparisons of milnacipran (F2207) and amitriptyline in endogenous depression. Psychopharmacology 5, 49-56.