A case for a neonatal, low-dose BCG vaccination trial

Scandinavian Journal of Infectious Diseases

Volumn 33, Issue 4, 2001, Pages 253-257

  Bretscher, P ^a   Menon, J ^a   Power, C ^a   Uzonna, J ^a   Wei, G ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ARTICLE; BCG VACCINATION; CLINICAL PROTOCOL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; GENETIC HETEROGENEITY; HUMAN; IMMUNE RESPONSE; MEMORY CELL; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NEWBORN; NEWBORN CARE; NONHUMAN; TH1 CELL; TH2 CELL; TUBERCULOSIS;

ANIMALS; ANTIBODY FORMATION; BCG VACCINE; CLINICAL TRIALS; DISEASE MODELS, ANIMAL; GENETICS, POPULATION; HUMANS; IMMUNITY, CELLULAR; IMMUNOCOMPROMISED HOST; IMMUNOLOGIC MEMORY; INFANT, NEWBORN; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; VACCINATION;

EID: 0035062853     PISSN: 00365548     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655401300077207     Document Type: Article

References (29)

1. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls
2. Th1/Th2 profiles in tuberculosis, based upon proliferation and the cytokine response of blood lymphocytes to mycobacterial antigens
3. The spectrum of human tuberculosis
4. Spectrum of immune response abnormalities in different clinical forms of tuberculosis
5. Establishment of stable cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major
6. Parasite dose determines the Th1/ Th2 nature of the response to Leishmania major independently of infection route and strain of host or parasite
7. The generation of distinct immune, pathophysiological states following Leishmania major infection in mice: Implications for immunological memory, vaccination and reactivation disease
8. Low level infection with Trichuris muris significantly affects the polarization of the CD4 response
9. CD4+ T-helper-cell responses in mice with low-level Candida albicans infections
10. An analysis of T cell responsiveness in Indian Kala-azar
11. The regulation of immunity to Leishmania major
12. Histological classification and the immunological spectrum of leprosy
13. Defining protective responses to pathogens: Cytokine profiles in leprosy lesions
14. Characterization of the immunological memory state generated in mice "susceptible" to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge
15. Mycobacterial dose defines the Th1/Th2 nature of the immune response independently of whether immunization is administered by the intravenous subcutaneous or intradermal route
16. Pathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte before infection
17. Immunological responses and protection against Mycobacterium bovis in calves vaccinated with a low dose of BCG
18. A strategy to improve the efficacy of vaccination against tuberculosis and leprosy
19. The Th1/Th2 nature of concurrent immune responses to unrelated antigens can be independent
20. Induction of protective CTL responses in newborn mice by a murine retrovirus
21. T cell memory is short-lived in the absence of antigen
22. T cell memory
23. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
24. Leishmania-HIV interaction: Immunopathogenic mechanisms
25. Persistence of virulent Leishmania major in murine cutaneous leishmaniasia: A possible hazard for the host
26. The host response to leishmania infection
27. Mechanisms of defense against P. faciparum asexual blood stage in humans
28. Immunoregulation of malarial infection: Balancing the vices and virtues