Combination gene therapy with adenoviral vector-mediated HSV-tk + GCV and IL-12 in an orthotopic mouse model for prostate cancer

Prostate Cancer and Prostatic Diseases

Volumn 4, Issue 1, 2001, Pages 44-55

  Nasu, Y ^a   Bangma, C H ^a   Hull, G W ^a   Yang, G ^a   Wang, J ^a   Shimura, S ^a   Mccurdy, M A ^a   Ebara, S ^a   Lee, H M ^a   Timme, T L ^a   Thompson, T C ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Antimetastatic activity; Gene therapy; Interleukin 12; Orthotopic tumor model; Prostate cancer; Thymidine kinase

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GANCICLOVIR; INTERLEUKIN 12; NITRIC OXIDE SYNTHASE; PENICILLIN G; STREPTOMYCIN; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL INFILTRATION; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG RESPONSE; GENE THERAPY; HERPES SIMPLEX VIRUS; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INJECTION; LUNG METASTASIS; LYMPH NODE METASTASIS; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MOLECULAR MIMICRY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; SPLEEN CELL; SURVIVAL; T LYMPHOCYTE;

EID: 0035061269     PISSN: 13657852     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500494     Document Type: Article

References (27)

1. Prostate cancer gene therapy: Herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models
2. Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer
3. In situ gene therapy for adenocarcinoma of the prostate: A phase I clinical trial
4. Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: Suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model
5. Combination gene therapy for liver metastasis of colon carcinoma in vivo
6. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained anti-tumor immunity prolongs animal survival
7. Inhibition of establishment of hepatic metastasis in mice by combination gene therapy using both herpes simplex virus-thymidine kinase and granulocyte macrophage-colony stimulating factor genes in murine colon cancer
8. Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer
9. Ganciclovir chemoablation of herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses
10. Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ
11. Progression to androgen insensitivity in a novel in vitro mouse model for prostate cancer
12. Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53
13. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
14. Association of transforming growth factor-beta 1 with prostate cancer: An immunohistochemical study
15. Elevated transforming growth factor-beta 1 and beta 3 mRNA levels are associated with ras + myc-induced carcinomas in reconstituted mouse prostate: Evidence for a paracrine role during progression
16. Oncogenes, growth factors, and hormones in prostate cancer
17. Transforming growth factor beta 1 as a biomarker for prostate cancer
18. Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer
19. In situ gene therapy for prostate cancer
20. Role of NK and T-cells in IL-12-induced anti-tumor response against hepatic colon carcinoma
21. Novel regulation of type IV collagenase (Matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta 1 in human prostate cancer cell lines
22. Transforming growth factor beta 1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro
23. Transforming growth factor-beta 1: Comparative immunohistochemical localization in human primary and metastatic prostate cancer
24. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta
25. Downregulation of interleukin-12 (IL-12) responsiveness in human T-cells by transforming growth factor-beta: Relationship with IL-12 signaling
26. Transforming growth factor β: The good, the bad, and the ugly
27. In vivo gene therapy with p53 or p21 adenovirus for prostate cancer