Ganciclovir chemoablation of herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses

Human Gene Therapy

Volumn 9, Issue 14, 1998, Pages 2019-2030

  Mullen, Craig A ^a   Anderson, Larry ^a   Woods, Kendra ^a   Nishino, Michiya ^a   Petropoulos, Demetrios ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; GANCICLOVIR; INTERLEUKIN 12; PRODRUG; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GENE TRANSFER; HERPES SIMPLEX VIRUS; IMMUNIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; SUICIDE GENE; T LYMPHOCYTE; TUMOR IMMUNITY; TUMOR MODEL; TUMOR REGRESSION; TUMOR RESISTANCE;

ANIMALIA; HERPES; SIMPLEXVIRUS;

EID: 0032552436     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.14-2019     Document Type: Article

References (13)

1. CARUSO, M., PHAM-NGUYEN, K., KWONG, Y.L., XU, B., KOSAI, K.I., FINEGOLD, M., WOO, S.L., and CHEN, S.H. (1996). Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc. Natl. Acad. Sci. U.S.A. 93, 11302-11306.
2. CHEN, S.H., KOSAI, K., XU, B., PHAM-NGUYEN, K., CONTANT, C., FINEGOLD, M.J., and WOO, S.L. (1996). Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival. Cancer Res. 56, 3758-3762.
3. CONSALVA, M., MULLEN, C.A., MODESTI, A., MUSIANI, P., ALLIONE, A., CAVALLO, F., GIOVARELLI, M., and FORNI, G. (1995). 5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory. J. Immunol. 154, 5302-5312.
4. CORNETTA, K., and ANDERSON, W.F. (1989). Protamine sulfate as an effective alternative to polybrene in retroviral-mediated genetransfer: Implications for human gene therapy. J. Virol. Methods 23, 187-194.
5. CULVER, K.W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
6. ELSHAMI, A.A., SAAVEDRA, A., ZHANG, H., KUCHARCZUK, J.C., SPRAY, D.C., FISHMAN, G.I., AMIN, K.M., KAISER, L.R., and ALBELDA, S.M. (1996). Gap junction play a role in the bystander effect of the herpes simplex virus thymidine kinase ganciclovir system in vitro. Gene Ther. 3, 85-92.
7. PICK, J., BARKER, F.G., DAZIN, P., WESTPHALE, E.M., BEYER, E.G., and ISRAEL, M.A. (1995). The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc. Natl. Acad. Sci. U.S.A. 92, 11071-11075.
8. FIDLER, I.J. (1975). Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res. 35, 218-234.
9. FREEMAN, S.M., ABBOUD, C.N., WHARTENBY, K.A., PACKMAN, C.H., KOEPLIN, D.S., MOOLTEN F.L., and ABRAHAM, G.N. (1993). The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
10. FREEMAN, S.M., RAMESH, R., SHASTRI, M., MUNSHI, A., JENSEN, A.K., and MARROGI, A.J. (1995). The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells. Cancer Lett. 92, 167-174.
11. FUCHS, E.J., and MATZINGER, P. (1996). Is cancer dangerous to the immune system? Semin. Immunol. 8, 271-280.
12. GAGANDEEP, S., BREW, R., GREEN, B., CHRISTMAS, S.E., KLATZMANN, D., POSTON, G.J., and KINSELLA, A.R. (1996). Prodrug-activated gene therapy: Involvement of an immunological component in the "bystander effect." Cancer Gene Ther. 3, 83-88.
13. HALL, S.J., MUTCHNIK, S.E., CHEN, S.H., WOO, S.L., and THOMPSON, T.C. (1997). Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostrate cancer. Int. J. Cancer 70, 183-187.