Structures and functions of TIMPs

Connective Tissue

Volumn 33, Issue 1, 2001, Pages 33-42

  Hayakawa, T ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Function; Growth modulating activity; Structure; Tissue inhibitor of metalloproteinases (TIMP)

Indexed keywords

METALLOPROTEINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

CANCER INVASION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROSIS; GROWTH REGULATION; INFLAMMATION; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN STRUCTURE; REVIEW;

EID: 0035055898     PISSN: 0916572X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (95)

1. The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth
2. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions
3. Multiple functions of tissue inhibitors of metalloproteinases (TIMPs): New aspects in hematopoiesis
4. The role of metalloproteinases and their inhibitors in hematologocal disorders
5. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
6. Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution
7. The human EBNA-2 coactivator p 100: Multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development
8. A growth-responsive gene (16 C 8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: Evidence for inducible and constitutive transcripts
9. Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2
10. Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinase-2
11. The purification of tissue inhibitor of metalloproteinase-2 from its 72 kDa progelatinase complex
12. Different domain interactions are involved in the binding of tissue inhibitor of metalloproteinases to stromelysin-1 and gelatinase A
13. The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family
14. Biochemical characterization of human collagenase-3
15. Processing of a precursor of 72-kilo Dalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase
16. The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation
17. Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-α receptors in a human colon adenocarcinoma (Colo 205) cell line
18. TIMP-3 induces cell death by stabilizing TNF-α receptors on the surface of human colon carcinoma cells
19. Nomenclature and glossary of the matrix metalloproteinases
20. TNF-α converting enzyme (TACE) is inhibited by TIMP-3
21. The in vivo activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3
22. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family
23. Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2
24. SV 40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
25. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzyme properties
26. Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A
27. A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumour growth
28. TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix
29. Localization of the functional domains of human tissue inhibitor of metalloproteinases-3 and the effects of a Sorsby's fundus dystrophy mutation
30. A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype on Sorsby's fundus dystrophy
31. Sorsby's fundus dystrophy without a mutation in the TIMP-3 gene
32. Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene
33. Involvement of AP 1 and PEA 3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription
34. Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)
35. Developmental expression of tissue inhibitor of metalloproteinases (TIMP) RNA
36. Temporal expression of tissue inhibitor of metalloproteinases in mouse reproductive tissues during gestation
37. Gene encoding a novel murine TIMP, TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle and is located on chromosome 10
38. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4
39. Murine tissue inhibitor of metalloproteinases-4 (TIMP-4): cDNA isolation and expression in adult mouse tissue
40. 1 progression, mitogenic stimulation, differentiation, and senescence
41. Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice
42. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid potentiating activity
43. Molecular characterization and expression of the gene encoding human erythroid-potentiating activity
44. Tissue inhibitor of metalloproteinase-2 (TIMP-2) has erythroid potentiating activity
45. Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1
46. Erythroid potentiating activity of tissue inhibitor of metalloproteinases on the differentiation of erythropoietin-responsive mouse erythroleukemia cell line, ELM-I-1-3, is closely related to its cell growth potentiating activity
47. Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)
48. Growth stimulation of human keratinocytes by tissue inhibitor of metalloproteinases
49. Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells
50. Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2)
51. The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: Possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis
52. Tissue inhibitor of metalloproteinase 1 (TIMP-1) may be an autocrine growth factor in scleroderma fibroblasts
53. Recombinant TIMP-1 and -2 enhance the proliferation of rabbit corneal epithelial cells in vitro and the spreading of rabbit corneal epithelium in situ
54. Tissue inhibitor of metalloproteinase (TIMP)-1 and proliferative behaviour of clonal breast cancer cells
55. TIMP-2, a growth-stimulating protein from SV-40 transformed human fibroblasts
56. Tissue inhibitor of metalloproteinase-2 stimulates fibroblast proliferation via a cAMP-dependent mechanism
57. TIMP-2 growth-stimulatory activity: A concentration- and cell type-specific response in the presence of insulin
58. The purification of tissue inhibitor of metalloproteinase-2 from its 72 kDa progelatinase complex
59. The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor
60. Biophysical and functional characterization of full-length, recombinant human tissue inhibitor of metalloproteinases-2 (TIMP-2) produced in Escherichia coli. Comparison of wild type and amino-terminal alanine appended variant with implications for the mechanism of TIMP functions
61. K 562 cells produce and respond to human erythroid-potentiating activity
62. Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts
63. A sandwich enzyme immunoassay for collagenase inhibitor using monoclonal antibodies
64. A one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases-2 using monoclonal antibodies
65. Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
66. Tissue inhibitor of metalloproteinases (TIMP-1) produced by granulosa and oviduct cells enhances in vitro development of bovine embryo
67. Effect of estrus-associated glycoprotein and tissue inhibitor of metalloproteinase-1 secreted by oviduct cells on in vitro bovine embryo development
68. Identification of a stimulator of steroid synthesis isolated from testis
69. Assessment of the role of tissue inhibitor of metalloproteinase-1 (TIMP-1) during the periovulatory period in female mice lacking a functional TIMP-1 gene
70. Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries
71. Production of tissue inhibitors of metalloproteinases (TIMPs) by pig ovarian cells in vivo and the effect of TIMP-1 on steroidgenesis in vitro
72. Disruption of the tissue inhibitor of metalloproteinase-1 gene results in altered reproductive cyclicity and uterine morphology in reproductive-age female mice
73. Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with TIMP-1
74. Novel implications in the development of endometriosis: Biphasic effect of macrophage activation on peritoneal tissue expression of tissue inhibitor of metalloproteinase-1
75. Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist therapy
76. Tissue inhibitor of metalloproteinase (TIMP)-1 induces differentiation and an antiapoptotic phenotype in germinal center B cells
77. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1
78. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells
79. TIMP-2 over-expression reduces invasion and angiogenesis and protects B 16 F 10 melanoma cells from apoptosis
80. Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene
81. Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros
82. Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits in vasion and induces apoptosis in melanoma cells
83. Divergent effects of tissue inhibitor of metalloproteinase-1, -2, -3 overexpression on rat vasccular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis
84. Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3
85. Newly established murine pituitary folliculo-stellate-like cell line secretes potent pituitary glandular cell survival factors
86. Tissue inhibitor of metalloproteinases (TIMP-1) stimulates the secretion of collagenase from human skin fibroblasts
87. Proteases occurring in the cell membrane: A possible cell receptor for the Bowman-Birk type protease inhibitors
88. Fluorescent visualization of binding and internalization of the anticarcinogenic Bowman-Birk type protease inhibitors in transformed fibroblasts
89. Cell cycle-dependent localization of tissue inhibitor of metalloproteinases-1 immunoreactivity in cultured human gingival fibroblasts
90. Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts
91. Tissue inhibitor of metalloproteinases-1 (TIMP-1) binds to the cell surface and translocates to the nucleus of human MCF-7 breast carcinoma cells
92. Regulation of tissue inhibitor of metalloproteinases-1 in rat Sertoli cells: Induction by germ cell residual bodies, interleukin-1α, and second messengers