Nuclear inositol lipid cycle: A new central intermediary in signal transduction

Anticancer Research

Volumn 16, Issue 6 A, 1996, Pages 3283-3286

  Manzoli, Lucia ^a,d   Stewart Gilmour, R ^b   Martelli, Alberto M ^c   Billi, Anna Maria ^d   Cocco, Lucio ^d  

^a UNIVERSITY OF CHIETI   (Italy)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF TRIESTE   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Inositol lipids; Nucleus; Phospholipase C

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; DIACYLGLYCEROL; MITOGENIC AGENT; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; PHOSPHOLIPID; PHOSPHOTRANSFERASE; POLYPHOSPHOINOSITIDE; PROTEIN KINASE C;

CANCER CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL MEMBRANE; CELL NUCLEUS; CELL TYPE; CHROMOSOME MAP; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; ERYTHROID CELL; HUMAN; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL NUCLEUS; DIGLYCERIDES; DNA REPLICATION; ENZYME ACTIVATION; INSULIN-LIKE GROWTH FACTOR I; ISOENZYMES; MICE; PHOSPHOLIPASE C; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION;

EID: 12644293803     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (10)

1. Cocco L, Martelli AM and GilmourRS: Inositol lipid cycle in the nucleus, (mini-review) Cell Signalling 6: 481-485, 1994.
2. Cocco L, Gilmour RS, Ognibene A, Manzoli FA and Irvine RF: Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J 248: 765-770, 1987.
3. Manzoli FA, Martelli AM, Capitani S, Maraldi NM, Rizzoli R, Barnabei O and Cocco L: Nuclear p-inositides during cell growth and differentiation. Advan Enzym Regul 28: 25-34., 1989.
4. 1 in Swiss 3T3. Nature (London) 258: 242-245, 1992.
5. Divecha N, Banfic H and Irvine RF: The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol andapparently induces translocation of protein kinase C to the nucleus. EMBO J 10: 3207-3214, 1991.
6. 1 decreases following cell differentiation in Friend cells, whereas g isoform is not affected. Eur J Cell Biol 68: 25-34, 1995.
7. Divecha N, Letcher AJ, Bantic H, Rhee SG and Irvine RF: Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleulaemia cell. Biochem J 312: 63-67, 1995.
8. Manzoli L, Billi AM, Gilmour RS, Martelli AM, Matteucci A, Ruhbini S, Weber G and Cocco L: Phosphoinositide signaling in nuclei of Friend cells: Tiazofurin downregulates phospholipase C. Cancer Res 55: 2978-2980, 1995.
9. Olah E, Natsumeda Y, Ikegami T, Kote Z, Horonyi M, Szelenyi J. Paulik E, Kremmer T, Hollan SR, Sugar J and Weber G: Induction of erythorid differentiation and modulation of gene expression by tiazofurin in K562 leukemia cells. Proc Natl Acad Sci USA 85: 6533-6537, 1988.
10. Billi AM, Cocco L, Martelli AM, Gilmour RS and Weber G: Tiazofurin -induced changes in nuclei of Friend crythroleukemia cells. Biochem Biophys Res Comm 195: 8-12, 1993.