Cloning and characterization of a potential transcriptional activator of human γ-globin genes

Blood Cells, Molecules, and Diseases

Volumn 27, Issue 1, 2001, Pages 1-15

  Yang, Yi ^a   Duan, Zhijun ^b   Skarpidi, Eva ^b   Li, Qiliang ^b   Papayannopoulou, Thalia ^a   Stamatoyannopoulos, George ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Differential mRNA display; Human globin gene; Somatic hybrids; Transcriptional activator

Indexed keywords

ANKYRIN; COMPLEMENTARY DNA; GAMMA GLOBIN; MESSENGER RNA;

ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROLEUKEMIA; FETUS; FETUS LIVER; GENE ACTIVATION; GENE EXPRESSION; GENE FUSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYBRID; HYBRIDIZATION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035052481     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2000.0344     Document Type: Article

References (45)

1. Hemoglobin switching
2. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins
3. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
4. Lethal-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
5. Activation of β-globin promoter by erythroid Krüppel-like factor
6. Human γ-globin genes silenced independently of other genes in the β-globin locus
7. Developmental regulation of human γ-globin genes in transgenic mice
8. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein
9. FKLF, a novel Krüppel-like factor that activates human embryonic and fetal β-like globin genes
10. FKLF-2: A novel Krüppel-like transcriptional factor that activates globin and other lineage gene
11. Analysis of human hemoglobin switching in MEL × human fetal erythroid cell hybrids
12. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
13. DNA sequencing with chain-terminating inhibitors
14. Improved tools for biological sequence comparison
15. Basic local alignment search tool
16. Northern hybridization: Rapid and simple electrophoretic conditions
17. Transformation of intact yeast cells treated with alkali cations
18. Binary transgenic mouse model for studying the trans control of globin gene switching: Evidence that GATA-1 is an in vivo repressor of human ε gene expression
19. cDNA cloning and interferon γ down-regulation of proteasomal subunits X and Y
20. Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene
21. Cell cycle control of the yeast HO gene: Cis- and trans-acting regulators
22. Identification of Ets- and Notch-related subunits in GA binding protein
23. The DNA binding subunit of NF-kB is identical to factor KBF1 and homologous to the rel oncogene product
24. The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interaction
25. The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch
26. glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins
27. Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats
28. Mouse mammary tumor gene int-3: A member of the notch gene family transforms mammary epithelial cells
29. Presence of a potent transcription activating sequence in the p53 protein
30. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
31. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
32. GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA
33. Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein
34. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
35. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast
36. Characterization of functional domains within the multifunctional transcription factor, YY1
37. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
38. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
39. Mechanism of action of a yeast activator: Direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions
40. A SWI/SNF-related chromatin remodeling complex, E-RC-1, is required for tissue-specific transcriptional regulation by EKLF in vitro
41. The Saccharomyces cerevisiae start-specific transcription factor swi4 interacts though the ankyrin repeats with the mitotic clb2/cdc28 kinase and though its conserved carboxyl terminus with swi6
42. Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein
43. Functional domains of transcription factor hGABP/β1/E4TF1-53 required for nuclear localization and transcription activation
44. Serum factors can modulate the developmental clock of γ- to β-globin gene switching in somatic cell hybrids