Duodenal expression of a putative stimulator of Fe transport and transferrin receptor in anemia and hemochromatosis

Gastroenterology

Volumn 120, Issue 6, 2001, Pages 1404-1411

  Barisani, Donatella ^a   Parafioriti, Antonina ^b   Armiraglio, Elisabetta ^b   Meneveri, Raffaella ^c   Conte, Dario ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b Ospedale Gaetano Pini Milan   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFERRIN RECEPTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DUODENUM BIOPSY; FEMALE; HEMOCHROMATOSIS; HUMAN; IMMUNOHISTOCHEMISTRY; IRON DEFICIENCY ANEMIA; IRON METABOLISM; IRON OVERLOAD; IRON TRANSPORT; MALE; METABOLIC DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035050178     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(01)80328-0     Document Type: Article

References (50)

1. Role of free radicals and catalytic metal ions in human disease: An overview
2. The pathology of hepatic iron overload: A free radical-mediated process?
3. Intestinal iron absorption: Current concepts circa 2000
4. Genetic disorders affecting proteins of iron metabolism. Clinical implications
5. Immunohistochemical evidence for a lack of ferritin in duodenal absorptive epithelial cells in idiopathic hemochromatosis
6. Regulation of transferrin, transferrin receptor and ferritin genes in human duodenum
7. A novel MCH class I-like gene is mutated in patients with hereditary hemochromatosis
8. HFE gene knockout produces mouse model of hereditary hemochromatosis
9. Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism
10. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
11. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
12. Crystal structure of the hereditary hemochromatosis protein HFE complexed with transferrin receptor
13. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
14. The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
15. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis
16. Overexpression of hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype
17. HFE downregulates iron uptake from transferrin and induces iron regulatory protein activity in stably transfected cells
18. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
19. Cloning and characterization of a second human Nramp on chromosome 12q13
20. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene
21. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
22. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
23. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
24. A novel mammalian iron-regulated protein involved in intracellular iron metabolism
25. Functional expression cloning and characterization of SFT, a stimulator of Fe transport
26. Structural and functional analysis of SFT, a stimulator of Fe transport
27. Expression of SFT (stimulator of Fe transport) is enhanced by iron chelation in HeLa cells and by hemochromatosis in the liver
28. Hemochromatosis and HLA-H
29. Polymorphism in intron 4 of HFE may cause overestimation of C282Y homozygote prevalence in hemochromatosis
30. A novel mutation of HFE explains the classical phenotype of genetic hemochromatosis in a C282Y heterozygote
31. The gene TFR2 is mutated in a new type of hemochromatosis mapping to 7q22
32. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
33. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
34. Intestinal mucosal uptake of iron and iron retention in idiopathic hemochromatosis as evidence for mucosal abnormality
35. Food iron absorption in hemochromatosis
36. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis
37. Duodenal ferritin synthesis in genetic hemochromatosis
38. Control of iron absorption
39. Duodenal metal transporter (DMT-1, NRAMP-2) expression in patients with hereditary hemochromatosis
40. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1
41. Characterization and chromosomal mapping of the human gene for SFT, a stimulator of Fe transport
42. Functional expression cloning and characterization of SFT, a stimulator of Fe transport
43. Localization of divalent metal transporter 1 (DMT1) to the microvillous membrane of rat duodenal enterocytes in iron deficiency but to hepatocytes in iron overload
44. DMT1 expression in duodenal biopsies from patients With disorders of iron metabolism
45. Transferrin receptors in the human gastrointestinal tract. Relationship to body iron stores
46. Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis
47. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index
48. Heterogeneity of hemochromatosis in Italy
49. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene