Inhibitory activity of quinolones against DNA gyrase of Mycobacterium tuberculosis

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 4, 2001, Pages 447-450

  Onodera, Y ^a   Tanaka, M ^a   Sato, K ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; AGAR; ALANINE; AMINO ACID; ASPARTIC ACID; BACTERIAL DNA; BACTERIAL ENZYME; CHLOROFORM; CIPROFLOXACIN; CYTOSINE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; ENZYME INHIBITOR; GLYCINE; GUANINE; HYBRID PROTEIN; ISOPROPYL THIOGALACTOSIDE; LEVOFLOXACIN; MALTOSE BINDING PROTEIN; NUCLEOTIDE; OLIGONUCLEOTIDE; PHENOL; PROTEINASE K; QUINOLONE DERIVATIVE; SITAFLOXACIN; SODIUM HYDROXIDE; SPARFLOXACIN; THYMINE; UNINDEXED DRUG; VALINE;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PURIFICATION; GENETIC ANALYSIS; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SEQUENCE ANALYSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 0035049109     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.4.447     Document Type: Article

References (10)

1. The clinical use of fluoroquinolones for the treatment of mycobacterial diseases
2. Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients
3. In-vitro and in-vivo activities of levofloxacin against Mycobacterium tuberculosis
4. Comparative in vitro antimicrobial activities of the newly synthesized quinolone HSR-903, sitafloxacin (DU-6859a), gatifloxacin (AM-1155), and levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex
5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
6. Gyrase mutation in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra
7. Correlation between quinolone susceptibility patterns and sequences in the A and B sub-units of DNA gyrase in mycobacteria
8. Purification and inhibition by quinolones of DNA gyrase from Mycobacterium avium, Mycobacterium smegmatis and Mycobacterium fortuitum bv. peregrinum
9. Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump
10. Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis