Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 8, 1996, Pages 1768-1774

  Kocagöz, Tanil ^a,b   Hackbarth, Corinne J ^a   Ünsal, Ibrahim ^a,b   Rosenberg, Emiko Y ^c   Nikaido, Hiroshi ^c   Chambers, Henry F ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); NORFLOXACIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; MINIMUM INHIBITORY CONCENTRATION; MISSENSE MUTATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0029822270     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.8.1768     Document Type: Article

References (50)

1. Alangaden, G. J., E. K. Manavathu, S. B. Vakulenko, N. M. Zvonok, and S. A. Lerner. 1995. Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients. Antimicrob. Agents Chemother. 39:1700-1703.
2. Ariza, R. R., S. P. Cohen, N. Bachhawat, S. B. Levy, and B. Demple. 1994. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. J. Bacteriol. 152:636-642.
3. Bryan, L. E., and J. Bedard. 1991. Impermeability to quinolones in gram-positive and gram-negative bacteria. Eur. J. Clin. Microbiol. 10:232-239.
4. Cambau, E., and L. Gutmann. 1993. Mechanisms of resistance to quinolones. Drugs 45(Suppl. 3):15-23.
5. Cambau, E., W. Sougakoff, and V. Jarlier. 1994. Amplification and nucleotide sequence of the quinolone resistance-determining region in the gyrA gene of mycobacteria. FEMS Microbiol. Lett. 116:49-54.
6. Chambers, H. F., D. Moreau, D. Yajko, C. Miick, C. Wagner, C. Hackbarth, S. Kocagöz, E. Rosenberg, W. K. Hadley, and H. Nikaido. 1995. Can penicillins and other β-lactam antibiotics be used to treat tuberculosis? Antimicrob. Agents Chemother. 39:2620-2624.
7. Chen, C. H., J. F. Shih, A. P. J. Lindholm-Levy, and L. B. Heifets. 1989. Minimal inhibitory concentrations of rifabutin, ciprofloxacin, and ofloxacin against Mycobacterium tuberculosis in patients in Taiwan. Am. Rev. Respir. Dis 140:987-989.
8. Cohen, S. P., D. C. Hooper, J. S. Wolfson, K. S. Souza, L. M. McMurry, and S. B. Levy. 1988. Endogenous active efflux of norfloxacin in susceptible E. coli. Antimicrob. Agents Chemother. 32:1187-1191.
9. A receptor of rat vagus nerve. Antimicrob. Agents Chemother. 38:1356-1362.
10. Dechene, M., H. Leying, and W. Cullmann. 1990. Role of outer membrane for quinolone resistance in enterobacteria. Chemotherapy (Basel) 36:13-23.
11. Denis, A., and N. J. Moreau. 1993. Mechanisms of quinolone resistance in clinical isolates: accumulation of sparfloxacin and of fluoroquinolones of various hydrophobicity, and analysis of membrane composition. J. Antimicrob. Chemother. 32:379-392.
12. Ferrero, L., B. Cameron, and J. Crouzet. 1995. Analysis of gyrA and gyrB mutations in stepwise selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 39:1554-1558.
13. Furet, Y. X., J. Deshusses, and J.-C. Pechere. 1992. Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus. Antimicrob. Agents Chemother. 36:2506-2511.
14. Hallet, P., and A. Maxwell. 1991. Novel quinolone resistance mutations of the Escherichia coll DNA gyrase A protein: enzymatic analysis of the mutant proteins. Antimicrob. Agents Chemother. 35:335-340.
15. Inderlied, C. 1991. Antimycobacterial agents: in vitro susceptibility testing, spectrums of activity, mechanisms of action and resistance, and assays for activity in biological fluids, p. 134-197. In V. Lorian (ed.), Antibiotics in laboratory medicine, 3rd ed. The Williams & Wilkins Co., Baltimore.
16. Ishil, H., K. Sato, K. Hoshino, M. Sato, A. Yamaguchi, T. Sawai, and Y. Osada. 1991. Active efflux of ofloxacin by a highly quinolone resistant strain of Proteus vulgaris. J. Antimicrob. Chemother. 28:827-836.
17. Jarlier, V., and H. Nikaido. 1990. Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J. Bacteriol. 172:1418-1423.
18. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1991. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus. J. Infect. Dis. 163:1080-1086.
19. Kocagöz, T., E. Yilmaz, S. Özkara, S. Kocagöz, M. Hayran, M. Sachdeva, and H. F. Chambers. 1993. Detection of Mycobacterium tuberculosis in sputum samples by polymerase chain reaction using a simplified procedure. J. Clin. Microbiol. 31:1435-1438.
20. Lalande, V., A. Truffot-Pernot, A. Paccaly-Moulin, and J. Grosset. 1993. Powerful activity of sparfloxacin (AT-4140) against Mycobacterium tuberculosis in mice. Antimicrob. Agents Chemother. 37:407-413.
21. Lee, C.-N., and L. B. Heifets. 1987. Determination of minimal inhibitory concentrations of antituberculosis drugs by radiometric and conventional methods. Am. Rev. Respir. Dis 136:349-352.
22. Levy, S. B. 1992. Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36:695-703.
23. Li, X. Z., D. M. Livermore, and H. Nikaido. 1994. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol and norfloxacin. Antimicrob. Agents Chemother. 38:1732-1741.
24. Li, X.-Z., D. Ma, D. M. Livermore, and H. Nikaido. 1994. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to β-lactam resistance. Antimicrob. Agents Chemother. 38:1742-1752.
25. Masuda, N., and S. Ohya. 1992. Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 35:2091-2097.
26. Michea-Hamzehpour, M., Y. X. Furet, and J.-C. Pechere. 1991. Role of protein D2 and lipopolysaccharide in diffusion of quinolones through the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 35:2091-2097.
27. Ng, E. Y. W., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob. Agents Chemother. 38:1345-1355.
28. Nikaido, H. 1976. Outer membrane of Salmonella typhimurium: transmembrane diffusion of some hydrophobic substances. Biochem. Biophys. Acta 433:118-132.
29. Nikaido, H. 1994. Prevention of drug access to bacterial targets: role of permeability barriers and active efflux. Science 264:382-388.
30. Nikaido, H., S.-H. Kim, and E. Y. Rosenberg. 1993. Physical organization of lipids in the cell wall of Mycobacterium chelonea. Mol. Microbiol. 8:1025-1030.
31. Nikaido, H., and D. G. Thanassi. 1993. Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples. Antimicrob. Agents Chemother. 37:1393-1399.
32. Nikaido, H., and M. Vaara. 1985. Molecular basis of bacterial outer membrane permeability. Microbiol. Rev. 49:1-32.
33. Oram, M., and L. M. Fisher. 1991. 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. Antimicrob. Agents Chemother. 35:387-389.
34. Piddock, L. J. V., and M. Zhu. 1991. Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria. Antimicrob. Agents Chemother. 35:2423-2427.
35. Poole, K., K. Krebes, C. McNally, and S. Neshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
36. Reece, R. J., and A. Maxwell. 1991. DNA gyrase: structure and function. Crit. Rev. Biochem. Mol. Biol. 26:335-375.
37. Revel, V., E. Cambau, V. Jarlier, and W. Sougakoff. 1994. Characterization of mutations in Mycobacterium smegmatis involved in resistance to fluoroquinolones. Antimicrob. Agents Chemother. 38:1991-1996.
38. Sanders, C. C. 1988. Ciprofloxacin. In vitro activity, mechanism of action, and resistance. Rev. Infect. Dis. 10:515-527.
39. Snider, D. E., and W. L. Rooper. 1992. The new tuberculosis. N. Engl. J. Med. 326:703-705.
40. Sreedharan, S., M. Oram, L. R. Peterson and L. M. Fisher. 1990. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J. Bacteriol. 172:7260-7262.
41. Sreedharan, S., L. R. Peterson, and L. M. Fisher. 1991. Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob. Agents Chemother. 35:2151-2154.
42. Takiff, H. E., L. Salazar, C. Guerrero, W. Philipp, W.-M. Huang, B. Kreiswirth, S. T. Cole, W. R. Jacobs, Jr., and A. Telenti. 1994. Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrob. Agents Chemother. 38:773-780.
43. Thanassi, D. G., G. S. B. Suh, and H. Nikaido. 1995. Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli. J. Bacteriol. 177:998-1007.
44. Trias, J., V. Jarlier, and R. Benz. 1992. Porins in the cell wall of mycobacteria. Science 258:1479-1481.
45. Wang, Y., W. M. Huang, and D. E. Taylor. 1993. Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. Antimicrob. Agents Chemother. 37:457-463.
46. Yamano, Y., T. Nishikawa, and Y. Komatsu. 1990. Outer membrane proteins responsible for the penetration of β-lactams and quinolones in Pseudomonas aeruginosa. J. Antimicrob. Chemother. 26:175-184.
47. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.
48. Yoshida, H., M. Bogaki, M. Nakamura, L. M. Yamanaka, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob. Agents Chemother. 35:1647-1650.
49. Yoshida, H., M. Bogaki, S. Nakamura, K. Ubukata, and M. Konno. 1990. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J. Bacteriol. 172:6942-6949.
50. Yoshimura, F., and H. Nikaido. 1982. Permeability of Pseudomonas aeruginosa outer membrane to hydrophyllic solutes. J. Bacteriol. 152:636-642.