Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus

Bone

Volumn 27, Issue 1, 2000, Pages 169-173

  Takacs, I ^a   Koller, D L ^a   Peacock, M ^a   Christian, J C ^a   Evans, W E ^a   Hui, S L ^a   Conneally, P M ^a   Johnston Jr , C C ^a   Foroud, T ^a   Econs, M J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone mineral density; Interleukin 6; Nonparametric linkage

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

ADULT; ARTICLE; BONE DENSITY; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OSTEOLYSIS; PATHOGENESIS; POSTMENOPAUSE OSTEOPOROSIS; RISK FACTOR; SIBLING;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; LINKAGE (GENETICS); MIDDLE AGED; NUCLEAR FAMILY; OSTEOPOROSIS;

EID: 0034123164     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(00)00296-9     Document Type: Article

References (38)

1. Bellido T., Jilka R.L., Boyce B.F., Girasole G., Bromeyer H., Dalrymple S.A., Murray R., Manologas S.C. Regulation of interleukin-6 osteoclastogenesis, and bone mass by androgens the role of the androgen receptor . J Clin Invest. 95:1995;2886-2895.
2. Bowcock, A. M., Kidd, J. R., Lathrop, G. M., Daneshvar L., May L. T., Ray A., Sehgal P. B., Kidd K. K., and Cavalli-Sforza L. L. The human "interferon-beta 2/hepatocyte stimulating factor/interleukin-6" gene: DNA polymorphism studies and localization to chromosome 7p21. Genomics 3:8-16; 1988.
3. Bowcock A.M., Ray A., Erlich H., Sehgal P.B. Rapid detection and sequencing of alleles in the 3′ flanking region of the interleukin-6 gene. Nucl Res. 17:1989;6855-6864.
4. Brewerton D.A., Hart F.D., Nicholls A., Caffery M., James D.C.O., Sturrock R.D. Ankylosing spondylitis and HLA-27. Lancet. 1:(7809):1973;904-907.
5. Christian J.C., Yu P-L, Slemenda C.W., Johnston C.C. Jr. Heritability of bone mass a longitudinal study in aging male twins . Am J Hum Genet. 44:1989;429-433.
6. De La Mata J., Uy H.L., Guise T.A., Story B., Boyce B.F., Mundy G.R., Roodman G.D. Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest. 95:1995;2846-2852.
7. Dequeker J., Nijis J., Vertraeten A., Guesens P., Gevers G. Genetic determinants of bone mineral content at the spine and radius a twin study . Bone. 8:1987;207-209.
8. Econs, M. J., Koller, D. L., Considine, E. L., Takacs, I., Christian, J. C., Conneally, P. M., Peacock, M., Johnston, C. C., Jr., and Foroud, T. Association and sib pair linkage analysis studies between BMD and the vitamin D receptor (VDR). Bone 23(Suppl.):271; 1998.
9. Econs M.J., Speer M.C. Genetic studies of complex diseases Let the reader beware . J Bone Min Res. 11:1996;1835-1840.
10. Goring H.H., Ott J. Relationship estimation in affected sib pair analysis of late-onset disease. Eur J Human Genet. 5:1997;69-77.
11. Greenfield E.M., Gornik S.A., Horowitz M.C., Donahue H.J., Shaw S.M. Regulation of cytokine expression in osteoblast by parathyroid hormone rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA . J Bone Miner Res. 8:1993;1163-1171.
12. Guegen R., Jouanny P., Guillemin F., Kuntz C., Pourel J., Siest G. Segregation analysis and variance components analysis of bone mineral density in healthy families. J Bone Miner Res. 12:1995;2017-2022.
13. Hansen M.A., Kirsten O., Riis B.J., Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis. Br Med J. 303:1991;961-964.
14. Hansen M.B., Svenson M., Abell K., Yasukawa K., Diamant M., Bendtzen K. Influence of interleukin-6 (IL-6) autoantibodies on IL-6 binding to cellular receptors. Eur J Immunol. 25:1995;348-354.
15. Hui S.L., Slemenda C.W., Johnston C.C. Jr. The contribution of rapid bone loss to postmenopausal osteoporosis. Osteopor Int. 1:1997;30-34.
16. Ishini Y., Miyaura C., Jin C.H., Akatsut A., Abe E., Nakamura Y., Yamaguchi A., Yoshiki S., Matsuda T., Hirano T., Kishimoto T., Suda T. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol. 145:1990;3297-3303.
17. Kelly P.J., Hopper J.L., Macaskill G.T., Pocock N.A., Sambrook P.N., Eisman J.A. Changes in axial bone density with age A twin study . J Bone Miner Res. 8:1993;11-17.
18. Kishimoto T., Akira S., Taga T. Interleukin-6 and its receptor a paradigm for cytokines . Science. 258:1992;593-597.
19. Kitamura H., Kauate H., Takahashi F., Higuchi Y., Turuichi T., Ohkawa H. Bone marrow neutrophilia and suppressed bone turnover in human interleukin-6 transgenic mice. Am J Pathol. 147:1995;1682-1692.
20. Kruglyak L., Lander E.S. Complete multipoint sib-pair linkage studies. Am J Hum Genet. 57:1995;439-454.
21. Kurihara N., Bertolini D., Suda T., Akiyanna Y., Roodman G.D. IL-6 stimulates osteoclast-like multinucleated cell formation in long term marrow cultures by inducing IL-1 release. J Immunol. 144:1990;4226-4230.
22. Lakatos P., Foldes J., Horvath C., Kiss L., Tatrai A., Takacs I., Tarjan G., Stern P. Serum interleukin-6 and bone metabolism in patients with thyroid function disorders. J Clin Endocrin Metab. 82:1997;78-81.
23. Lin S.C., Yamate T., Taguchi Y., Borba V.Z., Girasole G., O'Brien C.A., Bellido T., Abe E., Manologas S.C. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine marrow. J Clin Invest. 100:1997;1980-1990.
24. Madisen L., Hoar D.I., Holroyd C.D., Crisp M., Hodes M.E. DNA banking the effects of storage of blood and isolated DNA on the integrity of DNA . Am J Hum Genet. 27:1987;379-390.
25. May L.T., Neta R., Moldawer L.L., Kenney J.S., Patel K., Sehgal P.B. Antibodies chaperone circulating IL-6 paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo . J Immunol. 151:1993;3225-3236.
26. Mckane W.R., Khosla S., Peterson M.J., Egon K., Riggs B.L. Circulating levels of cytokines that modulate bone resorption effects of age and menopause in women . J Bone Miner Res. 9:1994;1313-1318.
27. Murray R.E., McGuigan F., Grant S.F., Reid D.M., Ralston S.G. Polymorphisms of the interleukin-6 gene are associated with bone mineral density. Bone. 21:1997;89-92.
28. Papadopulos N.G., Geoganes K., Skoutellas V., Konstantellos E., Lyritis G.P. Correlation of interleukin-6 serum levels with bone density in postmenopausal women. Clin Rheumatol. 16:1997;162-165.
29. Peacock M. Vitamin D receptor gene alleles and osteoporosis a contrasting view . J Bone Miner Res. 10:1995;1294-1297.
30. Pocock N.A., Eisman J.A., Hopper J.L., Yeates M.G., Sambrook P.N., Ebert S., Jerums G. Genetic determinants of bone mass in adults a twin study . J Clin Invest. 80:1987;706-710.
31. Pollock J.H., Blaha M.J., Lavish S.A., Stevenson S., Greenfield E.M. In vivo demonstration that parathyroid hormone and parathyroid hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor. J Bone Miner Res. 11:1996;754-759.
32. Pottratz S.T., Bellido T., Mocharla H., Crabb D., Manoglas S.C. 17 beta-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest. 93:1994;944-950.
33. Ralston S.H. Analysis of gene expression in human bone biopsies by polymerase chain reaction evidence for enhanced cytokine expression in postmenopausal osteoporosis . J Bone Miner Res. 9:1994;883-890.
34. Roodman G.D. Role of cytokines in the regulation of bone resorption. Calcif Tissue Int. 53:1995;594-598.
35. Salvi M., Girasole G., Pedrazzoni M., Giuliani N., Minelli R., Braverman L.E., Roti E. Increased serum concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor in patients with Graves' disease. J Clin Endocrin Metab. 81:1996;2976-2979.
36. Slemenda C.W., Christian J.C., Reed T., Reister T.K., Williams C.J., Johnston C.C. Jr. Long-term bone loss in men effects of genetic and environmental factors . Ann Intern Med. 117:1992;286-291.
37. Slemenda C.W., Christian J.C., Williams C.J., Norton J.A. Jr, Johnston C.C. Jr. Genetic determinants of bone mass in adult women a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates . J Bone Miner Res. 6:1991;561-567.
38. Udagava N., Takahashi N., Katagiri T., Tamura T., Wada S., Findlay D.M. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med. 182:1995;1461-1468.