A novel polymorphism in the promoter region for the human osteocalcin gene: The possibility of a correlation with bone mineral density in postmenopausal Japanese women

Journal of Bone and Mineral Research

Volumn 13, Issue 10, 1998, Pages 1633-1639

  Dohi, Yoshiko ^a   Iki, Masayuki ^b,c   Ohgushi, Hajime ^a   Gojo, Satoshi ^a   Tabata, Shiro ^a   Kajita, Etsuko ^d   Nishino, Harumi ^e   Yonemasu, Kunio ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOYAMA   (Japan)

^e TOYAMA INSTITUTE OF HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCALCIN;

ADULT; AGED; ARTICLE; BASE PAIRING; BONE DENSITY; BONE MINERAL; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; JAPAN; NORMAL HUMAN; POSTMENOPAUSE; PROMOTER REGION; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM;

AGED; AGED, 80 AND OVER; BONE DENSITY; FEMALE; GENETIC MARKERS; HUMANS; JAPAN; MIDDLE AGED; OSTEOCALCIN; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; POSTMENOPAUSE; PROMOTER REGIONS (GENETICS); SEQUENCE ANALYSIS, DNA;

EID: 0031691621     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.10.1633     Document Type: Article

References (26)

1. Nishimoto SK, Price PA 1980 Secretion of the vitamin K-dependent protein of bone by rat osteosarcoma cells. J Biol Chem 255:6579-6583.
2. Price PA 1987 Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects. Cohn DV, Martin TJ, Meunier PJ (eds.) Elsevier Science Publishers, Amsterdam, The Netherlands, pp. 419-425.
3. Lian JB, Gundberg CM 1988 Osteocalcin: Biochemical considerations and clinical applications. Clin Orthop 226:267-291.
4. 3. Biochemistry 27: 8521-8526.
5. Kesterson RA, Stanley L, DeMayo F, Finegold M, Pike JW 1993 The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice. Mol Endocrinol 7:462-467.
6. Heinrichs AAJ, Bortell R, Bourke M, Lian JB, Stein GS, Stein JL 1995 Proximal promoter binding protein contributes to developmental, tissue-restricted expression of the rat osteocalcin gene. J Cell Biochem 57:90-100.
7. Hoffmann HM, Beumer TL, Rahman S, McCabe LR, Banerjee C, Aslam F, Tiro JA, Wijnen AJ, van Stein JL, Stein GS, Lian JB 1996 Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor Hox proteins that bind the OC box. J Cell Biochem 61:310-324.
8. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G 1996 Increased bone formation in osteocalcin-deficient mice. Nature 382:448-452.
9. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA 1994 Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287.
10. Eisman JA 1995 Vitamin D receptor gene alleles and osteoporosis: An affirmative view. J Bone Miner Res 10:1284-1293.
11. Yamagata Z, Miyamura T, Iijima S, Asaka A, Sasaki M, Kato J, Koizumi K 1994 Vitamin D receptor gene polymorphism and bone mineral density in healthy Japanese women. Lancet 344: 1027.
12. Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M, Orimo H 1996 Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 11:306-311.
13. Hustmyer FG, Peacock M, Hui S, Johnston CC, Christian J 1994 Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 94:2130-2134.
14. Gurnero P, Borel O, Sornay-Rendu E, Delmas PD 1995 Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res 10:1283-1288.
15. Iki M, Dohi Y, Yonemasu K, Kajita E, Nishino H, Kusaka Y, Morita A, Sato K 1996 Vitamin D receptor gene haplotype and bone density in Japanese postmenopausal women. Osteoporos Int 6 (Suppl 1):S138.
16. Orita M, Suzuki Y, Seiya T, Hayashi K 1989 Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5:874-879.
17. Iki M, Kajita E, Dohi Y, Nishino H, Kusaka Y, Tsuchida C, Yamamoto K, Ishii Y 1996 Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women. Maturitus 25:59-67.
18. Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, Wozney JM 1986 Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J 5:1885-1890.
19. Mead DA, Pey NK, Herrnstadt C, Marcil RA, Smith LM 1991 A universal method for the direct cloning of PCR amplified nucleic acid. Biotechnology 9:657-663.
20. Sanger F, Nicklen S, Coulson A 1977 DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467.
21. Morrison NA, Shine J, Fragonas J-C, Verkest V, McMenemy ML, Eisman JA 1989 1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene. Science 246:1158-1161.
22. Orimo H, Sugioka Y, Fukunaga M, Muto Y, Hotokebuchi T, Gorai I, Nakamura T, Kushida K, Tanaka H, Inokai T 1996 Diagnositic criterion for primary osteoporosis. Osteoporosis Jpn 4:643-653 (in Japanese).
23. Peacock M 1995 Vitamin D receptor gene alleles and osteoporosis: A contrasting view. J Bone Miner Res 10:1294-1297.
24. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feldman D 1996 The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res 11:1850-1855.
25. Harris SS, Eccleshall TR, Gross C, Dawson-Hughes B, Feldman D 1997 The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women. J Bone Miner Res 12:1043-1048.
26. Lian JB, Stewart C, Puchacz E, Mackowiak S, Shalhoub V, Collart D, Zambetti G, Stein G 1989 Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci USA 86:1143-1147.