메뉴 건너뛰기




Volumn 28, Issue 2, 1996, Pages 159-172

Immunosuppressants: Cellular and molecular mechanisms of action

Author keywords

antiallograft response; cytokines; Immunosuppressants; monoclonal antibodies

Indexed keywords

15 DEOXYSPERGUALIN; AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ANTIBODY; LEFLUNOMIDE; LYMPHOCYTE ANTIBODY; MIZORIBINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; RAPAMYCIN; TACROLIMUS;

EID: 0029797781     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-6386(96)90297-8     Document Type: Review
Times cited : (129)

References (109)
  • 2
    • 0028038426 scopus 로고
    • MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
    • Germain RN: MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation. Cell 76:287-299, 1994
    • (1994) Cell , vol.76 , pp. 287-299
    • Germain, R.N.1
  • 4
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss A, Littman DR: Signal transduction by lymphocyte antigen receptors. Cell 76:263-264, 1994
    • (1994) Cell , vol.76 , pp. 263-264
    • Weiss, A.1    Littman, D.R.2
  • 6
    • 0028176656 scopus 로고
    • Indirect presentation of MHC antigens in transplantation
    • Shoskes DA, Wood KJ: Indirect presentation of MHC antigens in transplantation. Immunol Today 15:32-38, 1994
    • (1994) Immunol Today , vol.15 , pp. 32-38
    • Shoskes, D.A.1    Wood, K.J.2
  • 7
    • 0026162263 scopus 로고
    • The role of CD4 and CD8 in T-cell activation
    • Miceli MC, Parnes JR: The role of CD4 and CD8 in T-cell activation. Semin Immunol 3:133-141, 1991
    • (1991) Semin Immunol , vol.3 , pp. 133-141
    • Miceli, M.C.1    Parnes, J.R.2
  • 8
    • 0025315026 scopus 로고
    • A novel model for antigen-dependent activation of normal human T-cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor-α/β complex with the cluster determinant 2 antigen
    • Suthanthiran M: A novel model for antigen-dependent activation of normal human T-cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor-α/β complex with the cluster determinant 2 antigen. J Exp Med 171:1965-1979, 1990
    • (1990) J Exp Med , vol.171 , pp. 1965-1979
    • Suthanthiran, M.1
  • 9
    • 0024314938 scopus 로고
    • The CD2 antigen associates with the T-cell antigen receptor/CD3/antigen complex on the surface of human T lymphocytes
    • Brown MH, Cantrell DA, Brattsand G, Crumpton MJ, Gullberg M: The CD2 antigen associates with the T-cell antigen receptor/CD3/antigen complex on the surface of human T lymphocytes. Nature 339:551-553, 1989
    • (1989) Nature , vol.339 , pp. 551-553
    • Brown, M.H.1    Cantrell, D.A.2    Brattsand, G.3    Crumpton, M.J.4    Gullberg, M.5
  • 10
    • 0026598252 scopus 로고
    • Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5
    • Beyers AD, Spruyt LL, Williams AF: Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Acad Sci U S A 89:2945-2949, 1992
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 2945-2949
    • Beyers, A.D.1    Spruyt, L.L.2    Williams, A.F.3
  • 11
    • 0025971630 scopus 로고
    • T-cell antigen receptor activation pathways: The tyrosine kinase connection
    • Klausner RD, Samelson LE: T-cell antigen receptor activation pathways: The tyrosine kinase connection. Cell 64:875-878, 1991
    • (1991) Cell , vol.64 , pp. 875-878
    • Klausner, R.D.1    Samelson, L.E.2
  • 12
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614, 1992
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 13
    • 0026632557 scopus 로고
    • FK 506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
    • O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA: FK 506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357:692-694, 1992
    • (1992) Nature , vol.357 , pp. 692-694
    • O'Keefe, S.J.1    Tamura, J.2    Kincaid, R.L.3    Tocci, M.J.4    O'Neill, E.A.5
  • 14
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone NA, Crabtree GR: Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357:695-697, 1992
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 15
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-815, 1991
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 16
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin a
    • Fruman DA, Klee CB, Bierer BE, Burakoff SJ: Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A 89:3686-3690, 1992
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 17
    • 0027274979 scopus 로고
    • T-cell anergy
    • Schwartz RH: T-cell anergy. Sci Am 269:62-71, 1993
    • (1993) Sci Am , vol.269 , pp. 62-71
    • Schwartz, R.H.1
  • 18
    • 0027674621 scopus 로고
    • Signaling features of T-cells: Implications for the regulation of the anti-allograft response
    • Suthanthiran M: Signaling features of T-cells: Implications for the regulation of the anti-allograft response. Kidney Int 44:S3-S11, 1993
    • (1993) Kidney Int , vol.44
    • Suthanthiran, M.1
  • 19
    • 0024443411 scopus 로고
    • T-cell receptor crosslinking transiently stimulates adhesiveness through LFA-1
    • Dustin ML, Springer TA: T-cell receptor crosslinking transiently stimulates adhesiveness through LFA-1. Nature 341:619-624, 1989
    • (1989) Nature , vol.341 , pp. 619-624
    • Dustin, M.L.1    Springer, T.A.2
  • 23
    • 0028841784 scopus 로고
    • The yin and yang of T cell costimulation
    • Allison JP, Krummel MF: The yin and yang of T cell costimulation. Science 270:932-933, 1995
    • (1995) Science , vol.270 , pp. 932-933
    • Allison, J.P.1    Krummel, M.F.2
  • 24
    • 0026579147 scopus 로고
    • Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1
    • Isobe M, Yagita H, Okumura K, Ihara A: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255:1125-1127, 1992
    • (1992) Science , vol.255 , pp. 1125-1127
    • Isobe, M.1    Yagita, H.2    Okumura, K.3    Ihara, A.4
  • 26
    • 0022384437 scopus 로고
    • The events of primary T-cell activation can be staged by use of sepharose-bound anti-T3 [64.1] monoclonal antibody and purified interleukin-1
    • Williams JM, DeLoria D, Hansen JA, Dinarello CA, Loertscher R, Shapiro HM, Strom TB: The events of primary T-cell activation can be staged by use of sepharose-bound anti-T3 [64.1] monoclonal antibody and purified interleukin-1. J Immunol 135:2249-2255, 1985
    • (1985) J Immunol , vol.135 , pp. 2249-2255
    • Williams, J.M.1    DeLoria, D.2    Hansen, J.A.3    Dinarello, C.A.4    Loertscher, R.5    Shapiro, H.M.6    Strom, T.B.7
  • 27
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively
    • Bretcher P, Cohen M: A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 169:1042-1049, 1970
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretcher, P.1    Cohen, M.2
  • 28
    • 23444461024 scopus 로고
    • How B- and T-cells talk to each other
    • Clark EA, Ledbetter JA: How B- and T-cells talk to each other. Nature 367:425-428, 1994
    • (1994) Nature , vol.367 , pp. 425-428
    • Clark, E.A.1    Ledbetter, J.A.2
  • 29
    • 0026625939 scopus 로고
    • Immunophilin-sensitive protein phosphatase activation in cell signaling pathways
    • Schreiber SC: Immunophilin-sensitive protein phosphatase activation in cell signaling pathways. Cell 70:365-368, 1992
    • (1992) Cell , vol.70 , pp. 365-368
    • Schreiber, S.C.1
  • 30
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-β (TGF-β)
    • Roberts AB, Sporn MB: Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8:1-9, 1993
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 31
    • 0026009177 scopus 로고
    • Differential regulation of transforming growth factor beta and interleukin-2 genes in human T-cells: Demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction
    • Li B, Sehajpal PK, Khanna A, Vlassara H, Cerami A, Stenzel KH, Suthanthiran M: Differential regulation of transforming growth factor beta and interleukin-2 genes in human T-cells: Demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. J Exp Med 174:1259-1262, 1991
    • (1991) J Exp Med , vol.174 , pp. 1259-1262
    • Li, B.1    Sehajpal, P.K.2    Khanna, A.3    Vlassara, H.4    Cerami, A.5    Stenzel, K.H.6    Suthanthiran, M.7
  • 32
    • 0028207526 scopus 로고
    • Regulation of new DNA synthesis in mammalian cells by cyclosporine. Demonstration of a transforming growth factor β-dependent mechanism of inhibition of cell growth
    • Khanna A, Li B, Stenzel KH, Suthanthiran M: Regulation of new DNA synthesis in mammalian cells by cyclosporine. Demonstration of a transforming growth factor β-dependent mechanism of inhibition of cell growth. Transplantation 57:577-582, 1994
    • (1994) Transplantation , vol.57 , pp. 577-582
    • Khanna, A.1    Li, B.2    Stenzel, K.H.3    Suthanthiran, M.4
  • 33
    • 0023574619 scopus 로고
    • Glucocorticoids inhibit transcription and post-transcriptional expression of interleukin-1
    • Knudsen PJ, Dinarello CA, StromTB: Glucocorticoids inhibit transcription and post-transcriptional expression of interleukin-1. J Immunol 139:4129-4134, 1987
    • (1987) J Immunol , vol.139 , pp. 4129-4134
    • Knudsen, P.J.1    Dinarello, C.A.2    Strom, T.B.3
  • 34
    • 0025169732 scopus 로고
    • Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells
    • Zanker B, Walz G, Wieder KJ, Strom TB: Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells. Transplantation 49:183-185, 1990
    • (1990) Transplantation , vol.49 , pp. 183-185
    • Zanker, B.1    Walz, G.2    Wieder, K.J.3    Strom, T.B.4
  • 35
    • 0021173449 scopus 로고
    • Dexamethasone mediated inhibition of T-cell growth factor and gamma interferon messenger RNA
    • Arya SK, Wong-Staal F, Gallo RC: Dexamethasone mediated inhibition of T-cell growth factor and gamma interferon messenger RNA. J Immunol 133:273-276, 1984
    • (1984) J Immunol , vol.133 , pp. 273-276
    • Arya, S.K.1    Wong-Staal, F.2    Gallo, R.C.3
  • 36
    • 0025922666 scopus 로고
    • Abrogation of glucocorticosteroid-mediated inhibition of T-cell proliferation by the synergistic action of IL-1, IL-6, and IFN
    • Almawi WY, Lipman ML, Stevens AC, Zanker B, Hadro ET, Strom TB: Abrogation of glucocorticosteroid-mediated inhibition of T-cell proliferation by the synergistic action of IL-1, IL-6, and IFN. J Immunol 146:3523-3527, 1991
    • (1991) J Immunol , vol.146 , pp. 3523-3527
    • Almawi, W.Y.1    Lipman, M.L.2    Stevens, A.C.3    Zanker, B.4    Hadro, E.T.5    Strom, T.B.6
  • 37
    • 0026507209 scopus 로고
    • Glucocorticoid receptor-mediated suppression of the interleukin-2 gene expression through impairment of the cooperativity between nuclear factor of activated T-cells and AP-1 enhancer elements
    • Vacca A, Felli MP, Farina AR, Martinotti S, Maroder M, Screpanti I, Meco D, Petrangeli E, Frati L, Gulino A: Glucocorticoid receptor-mediated suppression of the interleukin-2 gene expression through impairment of the cooperativity between nuclear factor of activated T-cells and AP-1 enhancer elements. J Exp Med 175:637-646, 1992
    • (1992) J Exp Med , vol.175 , pp. 637-646
    • Vacca, A.1    Felli, M.P.2    Farina, A.R.3    Martinotti, S.4    Maroder, M.5    Screpanti, I.6    Meco, D.7    Petrangeli, E.8    Frati, L.9    Gulino, A.10
  • 38
    • 0025188132 scopus 로고
    • Transcriptional interference between cp-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
    • Yang-Yee HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M: Transcriptional interference between cp-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215, 1990
    • (1990) Cell , vol.62 , pp. 1205-1215
    • Yang-Yee, H.F.1    Chambard, J.C.2    Sun, Y.L.3    Smeal, T.4    Schmidt, T.J.5    Drouin, J.6    Karin, M.7
  • 39
    • 0027172987 scopus 로고
    • Negative transcriptional regulation of human interleukin-2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT
    • Palvogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT: Negative transcriptional regulation of human interleukin-2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J Clin Invest 91:1481-1487, 1993
    • (1993) J Clin Invest , vol.91 , pp. 1481-1487
    • Palvogianni, F.1    Raptis, A.2    Ahuja, S.S.3    Najjar, S.M.4    Boumpas, D.T.5
  • 40
    • 0028879819 scopus 로고
    • Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
    • Scheinman RI, Cogswell PG, Lofquist AK, Baldwin AS Jr: Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283-286, 1995
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.G.2    Lofquist, A.K.3    Baldwin Jr., A.S.4
  • 41
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NFκB activity through induction of IκB synthesis
    • Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: Inhibition of NFκB activity through induction of IκB synthesis. Science 270:286-290, 1995
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 42
    • 0014087635 scopus 로고
    • Biochemistry and pharmacology of purine analogues
    • Elion GB: Biochemistry and pharmacology of purine analogues. Fed Proc 26:898-904, 1967
    • (1967) Fed Proc , vol.26 , pp. 898-904
    • Elion, G.B.1
  • 43
    • 85025352713 scopus 로고
    • Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides
    • Morris RE: Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides. Transplant Rev 6:39-87, 1992
    • (1992) Transplant Rev , vol.6 , pp. 39-87
    • Morris, R.E.1
  • 45
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
    • Chung J, Kuo CJ, Crabtree GR, Blenis J: Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69:1227-1236, 1992
    • (1992) Cell , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 46
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J, Movva NR, Hall MN: Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909, 1991
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 47
    • 0028239893 scopus 로고
    • Raft-1: A mammalian protein that binds to FKBP 12 in a rapamycin dependent fashion and is homologous to yeast TORS
    • Sabatini DM, Erdjument Bromage H, Lui M, Tempst P, Snyder SH: Raft-1: A mammalian protein that binds to FKBP 12 in a rapamycin dependent fashion and is homologous to yeast TORS. Cell 78:35-43, 1994
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 48
    • 0027970168 scopus 로고
    • CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin
    • Lai JH, Tan H: CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin. J Biol Chem 269:30077-30080, 1994
    • (1994) J Biol Chem , vol.269 , pp. 30077-30080
    • Lai, J.H.1    Tan, H.2
  • 49
    • 0028909630 scopus 로고
    • Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement
    • Gregory CR, Huang X, Pratt RE, Dzau VJ, Shorthouse R, Billingham ME, Morris RE: Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. Transplantation 59:655-661, 1995
    • (1995) Transplantation , vol.59 , pp. 655-661
    • Gregory, C.R.1    Huang, X.2    Pratt, R.E.3    Dzau, V.J.4    Shorthouse, R.5    Billingham, M.E.6    Morris, R.E.7
  • 50
    • 0026031552 scopus 로고
    • Comparison of the immunosuppressive effects of mycophenolic acid and the morpholinethal ester of mycophenolic acid (RS-61443) in recipients of heart grafts
    • Morris RE, Wang J: Comparison of the immunosuppressive effects of mycophenolic acid and the morpholinethal ester of mycophenolic acid (RS-61443) in recipients of heart grafts. Transplant Proc 23:493-506, 1991
    • (1991) Transplant Proc , vol.23 , pp. 493-506
    • Morris, R.E.1    Wang, J.2
  • 51
    • 0027786826 scopus 로고
    • Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil
    • Allison AC, Eugui EM: Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 136:5-19, 1993
    • (1993) Immunol Rev , vol.136 , pp. 5-19
    • Allison, A.C.1    Eugui, E.M.2
  • 52
    • 0029006409 scopus 로고
    • Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection
    • European Mycophenolate Mofetil Cooperative Study Group: Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345:1321-1325, 1995
    • (1995) Lancet , vol.345 , pp. 1321-1325
  • 53
    • 0029115531 scopus 로고
    • Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients
    • Sollinger HW, for the US Renal Transplant Mycophenolate Mofetil Study Group: Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. Transplantation 60:225-232, 1995
    • (1995) Transplantation , vol.60 , pp. 225-232
    • Sollinger, H.W.1
  • 54
    • 0025821616 scopus 로고
    • Guanine ribonucleotide depletion inhibits T-cell activation: Mechanism of action of the immunosuppressive drug mizoribine
    • Turka LA, Dayton J, Sinclair G, Thompson CB, Mitchell BS: Guanine ribonucleotide depletion inhibits T-cell activation: Mechanism of action of the immunosuppressive drug mizoribine. J Clin Invest 87:940-948, 1991
    • (1991) J Clin Invest , vol.87 , pp. 940-948
    • Turka, L.A.1    Dayton, J.2    Sinclair, G.3    Thompson, C.B.4    Mitchell, B.S.5
  • 55
    • 0025031545 scopus 로고
    • Low dose ciclosporin, mizoribine and prednisone in renal transplantation: A new triple drug therapy
    • Kokado Y, Ishibahi M, Jiang H: Low dose ciclosporin, mizoribine and prednisone in renal transplantation: A new triple drug therapy. Clin Transplant 4:191-197, 1990
    • (1990) Clin Transplant , vol.4 , pp. 191-197
    • Kokado, Y.1    Ishibahi, M.2    Jiang, H.3
  • 57
    • 0022364247 scopus 로고
    • Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety
    • Tokyo
    • Umeda Y, Moriguchi M, Kuroda H, Nakamura T, Iinuma H, Takeuchi T, Umezawa H: Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety. J Antibiot (Tokyo) 38:886-898, 1985
    • (1985) J Antibiot , vol.38 , pp. 886-898
    • Umeda, Y.1    Moriguchi, M.2    Kuroda, H.3    Nakamura, T.4    Iinuma, H.5    Takeuchi, T.6    Umezawa, H.7
  • 58
    • 0026526303 scopus 로고
    • Interaction of the immuno-suppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins
    • Nadler SG, Tepper MA, Schacter B, Mazzucco CE: Interaction of the immuno-suppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. Science 258:484-486, 1992
    • (1992) Science , vol.258 , pp. 484-486
    • Nadler, S.G.1    Tepper, M.A.2    Schacter, B.3    Mazzucco, C.E.4
  • 59
    • 0027786829 scopus 로고
    • The development of brequinar as an immunosuppressive drug for transplantation
    • Makowka L, Sher LS, Cramer DV: The development of brequinar as an immunosuppressive drug for transplantation. Immunol Rev 136:51-70, 1993
    • (1993) Immunol Rev , vol.136 , pp. 51-70
    • Makowka, L.1    Sher, L.S.2    Cramer, D.V.3
  • 60
    • 9444262785 scopus 로고    scopus 로고
    • Inhibitors of de novo nucleotide synthesis in the treatment of rheumatoid arthritis
    • Strand V (ed): New York, NY, Marcel Dekker, in press
    • Fox RI, Morris RE: Inhibitors of de novo nucleotide synthesis in the treatment of rheumatoid arthritis, in Strand V (ed): Emerging Therapies for Autoimmune Diseases. New York, NY, Marcel Dekker, 1996 (in press)
    • (1996) Emerging Therapies for Autoimmune Diseases
    • Fox, R.I.1    Morris, R.E.2
  • 62
    • 0029620896 scopus 로고
    • Mechanism of the antiproliferative action of leflunomide: A77 1726, the active metabolite of leflunomide, does not block T cell receptor-mediated signal transduction but its antiproliferative effects are antagonized by pyrimidine nucleosides
    • Cao WW, Kao PN, Chao AC, Gardener P, Ng J, Morris RE: Mechanism of the antiproliferative action of leflunomide: A77 1726, the active metabolite of leflunomide, does not block T cell receptor-mediated signal transduction but its antiproliferative effects are antagonized by pyrimidine nucleosides. J Heart Lung Transplant 14:1016-1030, 1995
    • (1995) J Heart Lung Transplant , vol.14 , pp. 1016-1030
    • Cao, W.W.1    Kao, P.N.2    Chao, A.C.3    Gardener, P.4    Ng, J.5    Morris, R.E.6
  • 64
    • 0028837380 scopus 로고
    • Mechanism of leflunomide-induced prevention of xenoantibody formation and xenograft rejection in the hamster to rat heart transplantation model
    • Lin Y, Sobis H, Vandeputte M, Waer M: Mechanism of leflunomide-induced prevention of xenoantibody formation and xenograft rejection in the hamster to rat heart transplantation model. Transplant Proc 27:305-306, 1995
    • (1995) Transplant Proc , vol.27 , pp. 305-306
    • Lin, Y.1    Sobis, H.2    Vandeputte, M.3    Waer, M.4
  • 66
    • 0029025918 scopus 로고
    • Leflunomide: An active antiinflammatory and antiproliferative agent in models of dermatologic disease
    • Switzerland
    • Kurtz ES, Bailey SC, Arshad F, Lee AA, Przekop PA: Leflunomide: An active antiinflammatory and antiproliferative agent in models of dermatologic disease. Inflamm Res (Switzerland) 44:S187-S188, 1995 (suppl 2)
    • (1995) Inflamm Res , vol.44 , Issue.2 SUPPL.
    • Kurtz, E.S.1    Bailey, S.C.2    Arshad, F.3    Lee, A.A.4    Przekop, P.A.5
  • 70
    • 0029050136 scopus 로고
    • Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide
    • Greene S, Watanabe K, Braatz-Trulson J, Lou L: Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem Pharmacol 50:861-867, 1995
    • (1995) Biochem Pharmacol , vol.50 , pp. 861-867
    • Greene, S.1    Watanabe, K.2    Braatz-Trulson, J.3    Lou, L.4
  • 71
    • 0029052321 scopus 로고
    • Inhibition of protein tyrosine phosphorylation in T cells by a novel immnosuppressive agent, leflunomide
    • Xu X, Williams JW, Bremer EG, Finnegan A, Chong AS-F: Inhibition of protein tyrosine phosphorylation in T cells by a novel immnosuppressive agent, leflunomide. J Biol Chem 270:12398-12403, 1995
    • (1995) J Biol Chem , vol.270 , pp. 12398-12403
    • Xu, X.1    Williams, J.W.2    Bremer, E.G.3    Finnegan, A.4    Chong, A.S.-F.5
  • 72
    • 0028895216 scopus 로고
    • Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine
    • Nair RV, Cao W, Morris RE: Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunol Lett 47:171-174, 1995
    • (1995) Immunol Lett , vol.47 , pp. 171-174
    • Nair, R.V.1    Cao, W.2    Morris, R.E.3
  • 73
    • 0029060245 scopus 로고
    • Studies in experimental models of chronic rejection: Use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogues) for the suppression of graft vascular disease and obliterative bronchiolitis
    • Morris RE, Iluang XF, Shorthouse R, Reichenspurner H, Adams B, Berry G: Studies in experimental models of chronic rejection: Use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogues) for the suppression of graft vascular disease and obliterative bronchiolitis. Transplant Proc 27:2068-2069, 1995
    • (1995) Transplant Proc , vol.27 , pp. 2068-2069
    • Morris, R.E.1    Iluang, X.F.2    Shorthouse, R.3    Reichenspurner, H.4    Adams, B.5    Berry, G.6
  • 74
    • 0028840755 scopus 로고
    • Review and preview of anti-T-cell antibodies
    • Helderman JH: Review and preview of anti-T-cell antibodies. Transplant Proc 27:8-9, 1995
    • (1995) Transplant Proc , vol.27 , pp. 8-9
    • Helderman, J.H.1
  • 75
    • 0026718112 scopus 로고
    • Antilymphocyte antibodies in the treatment of allograft rejection: Targets, mechanisms of action, monitoring, and efficacy
    • Norman DJ: Antilymphocyte antibodies in the treatment of allograft rejection: Targets, mechanisms of action, monitoring, and efficacy. Semin Nephrol 12:315-324, 1992
    • (1992) Semin Nephrol , vol.12 , pp. 315-324
    • Norman, D.J.1
  • 76
    • 0026592441 scopus 로고
    • Analysis of the UNOS scientific renal transplant registry at three years - Early events affecting transplant success
    • Cecka JM, Cho YW, Terasaki PI: Analysis of the UNOS scientific renal transplant registry at three years - Early events affecting transplant success. Transplantation 53:59-64, 1992
    • (1992) Transplantation , vol.53 , pp. 59-64
    • Cecka, J.M.1    Cho, Y.W.2    Terasaki, P.I.3
  • 77
    • 0019140089 scopus 로고
    • Therapy of acute cadaveric renal allograft rejection with adjunctive antithymocyte globulin
    • Filo RS, Smith EJ, Leapman SB: Therapy of acute cadaveric renal allograft rejection with adjunctive antithymocyte globulin. Transplantation 30:445-449, 1980
    • (1980) Transplantation , vol.30 , pp. 445-449
    • Filo, R.S.1    Smith, E.J.2    Leapman, S.B.3
  • 78
    • 0021816056 scopus 로고
    • A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
    • Ortho Multicenter Transplant Study Group: A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. N Engl J Med 313:337-342, 1985
    • (1985) N Engl J Med , vol.313 , pp. 337-342
  • 82
    • 0027499247 scopus 로고
    • OKT3-induced cytokine-release syndrome: Preventive effect of anti-tumor necrosis factor monoclonal antibody
    • Chatenoud L: OKT3-induced cytokine-release syndrome: Preventive effect of anti-tumor necrosis factor monoclonal antibody. Transplant Proc 25:47-51, 1993
    • (1993) Transplant Proc , vol.25 , pp. 47-51
    • Chatenoud, L.1
  • 85
    • 0025215566 scopus 로고
    • Randomized controlled trial of a monoclonal antibody against the interleukin-2 receptor (33B3.1) as compared with rabbit antithymocyte globulin for prophylaxis against rejection of renal allografts
    • Soulillou J-P, Cantarovich D, Le Mauff B, Gival M, Robillard N, Hourmant M, Him M, Jacques Y: Randomized controlled trial of a monoclonal antibody against the interleukin-2 receptor (33B3.1) as compared with rabbit antithymocyte globulin for prophylaxis against rejection of renal allografts. N Engl J Med 322:1175-1182, 1990
    • (1990) N Engl J Med , vol.322 , pp. 1175-1182
    • Soulillou, J.-P.1    Cantarovich, D.2    Le Mauff, B.3    Gival, M.4    Robillard, N.5    Hourmant, M.6    Him, M.7    Jacques, Y.8
  • 87
    • 0027018312 scopus 로고
    • Transplantation 1992: The year in review
    • Terasaki PI, Cecka JM (eds): Los Angeles, CA, UCLA Tissue Typing Laboratory
    • Goodman ER, Hardy MA: Transplantation 1992: The year in review, in Terasaki PI, Cecka JM (eds): Clinical Transplants 1992. Los Angeles, CA, UCLA Tissue Typing Laboratory, 1993, pp 285-297
    • (1993) Clinical Transplants 1992 , pp. 285-297
    • Goodman, E.R.1    Hardy, M.A.2
  • 88
    • 0028799369 scopus 로고
    • The potential role of therapeutic antibodies in the regulation of rejection
    • Ettinger RM, Yadin O: The potential role of therapeutic antibodies in the regulation of rejection. Transplant Proc 27:13-17, 1995
    • (1995) Transplant Proc , vol.27 , pp. 13-17
    • Ettinger, R.M.1    Yadin, O.2
  • 89
    • 0028069390 scopus 로고
    • Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival
    • Qin L, Chavin KD, Lin J, Yagita H, Bromberg JS: Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J Exp Med 179:341-346, 1994
    • (1994) J Exp Med , vol.179 , pp. 341-346
    • Qin, L.1    Chavin, K.D.2    Lin, J.3    Yagita, H.4    Bromberg, J.S.5
  • 90
    • 0029898715 scopus 로고    scopus 로고
    • CD2 antigen targeting reduces intragraft expression of mRNA encoding granzyme B and IL-10 and induces tolerance
    • in press
    • Kapur S, Khanna A, Sharma VK, Li B, Suthanthiran M: CD2 antigen targeting reduces intragraft expression of mRNA encoding granzyme B and IL-10 and induces tolerance. Transplantation 62:1996 (in press)
    • Transplantation , vol.62 , pp. 1996
    • Kapur, S.1    Khanna, A.2    Sharma, V.K.3    Li, B.4    Suthanthiran, M.5
  • 93
    • 0022903308 scopus 로고
    • Cyclosporine nephrotoxicity
    • Meyers BD: Cyclosporine nephrotoxicity. Kidney Int 30:964-974, 1986
    • (1986) Kidney Int , vol.30 , pp. 964-974
    • Meyers, B.D.1
  • 94
    • 0005732822 scopus 로고
    • Clinical benefits of calcium antagonists in renal transplant recipients
    • Epstein M (ed): Philadelphia, PA, Hanley and Belfus
    • Weir MR: Clinical benefits of calcium antagonists in renal transplant recipients, in Epstein M (ed): Calcium Antagonists in Clinical Medicine. Philadelphia, PA, Hanley and Belfus, 1992, pp 391-412
    • (1992) Calcium Antagonists in Clinical Medicine , pp. 391-412
    • Weir, M.R.1
  • 95
    • 0023232415 scopus 로고
    • Cellular calcium in ischemic acute renal failure: Role of calcium entry blockers
    • Schrier RW, Arnold PE, Van Putten VJ, Burke TJ: Cellular calcium in ischemic acute renal failure: Role of calcium entry blockers. Kidney Int 32:313-322, 1987
    • (1987) Kidney Int , vol.32 , pp. 313-322
    • Schrier, R.W.1    Arnold, P.E.2    Van Putten, V.J.3    Burke, T.J.4
  • 96
    • 0026855890 scopus 로고
    • Protective effects of calcium antagonists in human renal transplantation
    • Neumayer H-H, Kunzendorf U, Schreiber M: Protective effects of calcium antagonists in human renal transplantation. Kidney Int 41:S87-S93, 1992
    • (1992) Kidney Int , vol.41
    • Neumayer, H.-H.1    Kunzendorf, U.2    Schreiber, M.3
  • 100
    • 0343769445 scopus 로고
    • Supplementation of immunosuppressive regimens with calcium channel blockers. Rationale and clinical efficacy
    • Weir MR, Suthanthiran M: Supplementation of immunosuppressive regimens with calcium channel blockers. Rationale and clinical efficacy. Clin Immunother 2:458-467, 1994
    • (1994) Clin Immunother , vol.2 , pp. 458-467
    • Weir, M.R.1    Suthanthiran, M.2
  • 102
    • 0024357488 scopus 로고
    • Enhancement of immunosuppression by substitution of fish oil for olive oil as a vehicle for cyclosporine
    • Kelley VE, Kirkman RL, Bastos M, Barrett LV, Strom TB: Enhancement of immunosuppression by substitution of fish oil for olive oil as a vehicle for cyclosporine. Transplantation 48:98-102, 1989
    • (1989) Transplantation , vol.48 , pp. 98-102
    • Kelley, V.E.1    Kirkman, R.L.2    Bastos, M.3    Barrett, L.V.4    Strom, T.B.5
  • 103
    • 0023832080 scopus 로고
    • Selective enhancement of thromboxane in macrophages and kidneys in cyclosporine-induced nephrotoxicity. Dietary protection by fish oil
    • Rogers TS, Elzinga L, Bennett WM, Kelley VE: Selective enhancement of thromboxane in macrophages and kidneys in cyclosporine-induced nephrotoxicity. Dietary protection by fish oil. Transplantation 45:153-156, 1988
    • (1988) Transplantation , vol.45 , pp. 153-156
    • Rogers, T.S.1    Elzinga, L.2    Bennett, W.M.3    Kelley, V.E.4
  • 104
    • 0027329064 scopus 로고
    • Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants
    • Van Der Heide JJH, Bilo HJG, Donker JM, Wilmink JM, Tegzess AM: Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants. N Engl J Med 329:769-773, 1993
    • (1993) N Engl J Med , vol.329 , pp. 769-773
    • Van Der Heide, J.J.H.1    Bilo, H.J.G.2    Donker, J.M.3    Wilmink, J.M.4    Tegzess, A.M.5
  • 105
    • 0029089702 scopus 로고
    • Ketoconazole to reduce the need for cyclosporine after cardiac transplantation
    • Keogh A, Spratt P, McCosker C, Macdonald P, Mundy J, Kaan A: Ketoconazole to reduce the need for cyclosporine after cardiac transplantation. N Engl J Med 333:628-633, 1995
    • (1995) N Engl J Med , vol.333 , pp. 628-633
    • Keogh, A.1    Spratt, P.2    McCosker, C.3    Macdonald, P.4    Mundy, J.5    Kaan, A.6
  • 108
    • 85030269389 scopus 로고    scopus 로고
    • Mechanisms of graft rejection
    • Sayegh MH, Turka LA (eds): Philadelphia, PA, CoMed Communications
    • Strom TB, Suthanthiran M: Mechanisms of graft rejection, in Sayegh MH, Turka LA (eds): ASTP Lectures in Transplantation. Philadelphia, PA, CoMed Communications, 1996
    • (1996) ASTP Lectures in Transplantation
    • Strom, T.B.1    Suthanthiran, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.