The role of phosphoinositide 3-kinase in spreading osteoclasts induced by colony-stimulating factor-1

European Journal of Endocrinology

Volumn 144, Issue 4, 2001, Pages 431-440

  Palacio, S ^a   Felix, R ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; TYROSINE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CELL LYSATE; CELL MIGRATION; CELL SPREADING; COCULTURE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; THIN LAYER CHROMATOGRAPHY;

EID: 0035035933     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1440431     Document Type: Article

References (44)

1. Colony stimulating factor-1 (Macrophage colony stimulating factor)
2. Role of colony-stimulating factor-I in bone metabolism
3. Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse
4. Morphological evidence of reduced bone resorption in osteopetrotic (op) mice
5. Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse
6. Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts
7. Detection of transcripts and binding sites for colony-stimulating factor-I during bone development
8. Macrophage colony-stimulating factor release and receptor expression in bone cells
9. Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclast
10. Downregulation of colony-stimulating factor-I (CSF-I) binding by CSF-I in isolated osteoclast
11. Macrophage colony stimulating factor increases bone resorption in dispersed osteoclast cultures by increasing osteoclast size
12. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase
13. Phosphoinositide 3-kinases: A conserved family of signal transducers
14. The role of phosphoinositide 3-kinase lipid products in cell function
15. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity
16. Downstream of phosphatidylinositol-3 kinase, a multifunctional signaling molecule, and its regulation in cell responses
17. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phospho-proteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit
18. Regulation of the p85/pH alpha phosphatidylinositol 3′-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains
19. Activation of phosphonositide 3-kinase by interaction with Ras and by point mutation
20. Wortmannin a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro
21. Wortmannin a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption
22. Effects of wortmannin analogs on bone in vitro and in vivo
23. Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts
24. Cytoskeletal changes in osteoclasts during the resorption cycle
25. Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
26. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
27. Preparation and characterization of a mouse osteoclast-like multinucleated cell population
28. c-fos antisense DNA inhibits proliferation of osteoclast progenitors in osteoclast development but not macrophage differentiation in vitro
29. Colony-stimulating factor-1 stimulates the fusion process in osteoclast
30. Fimbrin in podosomes of monocyte-derived osteoclast
31. Constitutive activation of protein kinase B and phosphorylation of p47 phox by a membrane-targeted phosphoinositide 3-kinase
32. The Gβγ sensitivity of a PI 3K is dependent upon a tightly associated adaptor, p101
33. Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in in vitro
34. Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1
35. Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages
36. Structural features of the colony-stimulating factor I receptor that affect its association with phosphatidylinositol 3-kinase
37. Tyr 721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: A model for SH2-mediated receptor-target interactions
38. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
39. Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes
40. Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts
41. Colony stimulating factor-I-induced osteoclast spreading depends on substrate and requires the vitronectin receptor and the c-src proto-oncogene
42. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase
43. Stable association of PYK2 and p(130) Cas in their colocalization in the sealing zone
44. Role of substrates and products of P13-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav