Review article: The management of severe Crohn's disease

Alimentary Pharmacology and Therapeutics

Volumn 15, Issue 5, 2001, Pages 563-573

  Parkes, M ^a   Jewell, D P ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIBODY; ANTISENSE OLIGODEOXYNUCLEOTIDE; AZATHIOPRINE; BUDESONIDE; CELL ADHESION MOLECULE; CIPROFLOXACIN; CORTICOSTEROID; CYCLOSPORIN; HYDROCORTISONE; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; METRONIDAZOLE; MYCOPHENOLIC ACID; PREDNISOLONE; PROBIOTIC AGENT; RECOMBINANT INTERLEUKIN 10;

ANTIBIOTIC THERAPY; ANUS FISTULA; BONE MARROW SUPPRESSION; CLINICAL TRIAL; CROHN DISEASE; DIET THERAPY; DISEASE SEVERITY; DRUG EFFICACY; DRUG TOLERABILITY; FLU LIKE SYNDROME; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE RESECTION; INTESTINE SURGERY; LIVER TOXICITY; MEDICAL DECISION MAKING; NURSING; NUTRITIONAL SUPPORT; OSTEOPOROSIS; PATIENT SELECTION; PERIANAL ABSCESS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PSYCHOSIS; RASH; REMISSION; REVIEW; STEROID THERAPY;

ACUTE DISEASE; ADRENAL CORTEX HORMONES; CHRONIC DISEASE; CROHN DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PATIENT CARE PLANNING; PROGNOSIS; SEVERITY OF ILLNESS INDEX;

EID: 0035035376     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2001.00963.x     Document Type: Review

References (76)

1. National Cooperative Crohn's Disease Study: Results of drug treatment
2. European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment
3. Thromboembolism in inflammatory bowel disease: Role of platelets
4. Thrombosis in inflammatory bowel disease: Clinical setting, procoagulant profile and factor V Leiden
5. Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn's disease with intravenous cyclosporine
6. Intravenous cyclosporin as rescue therapy in severe ulcerative colitis: Time for a reappraisal?
7. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease
8. Clinical course of colorectal Crohn's disease: A 35-year follow-up study of 507 patients
9. Aminosalicylates for active disease and in the maintenance of remission in Crohn's disease
10. Absorption of prednisolone in patients with Crohn's disease
11. Use of an intravenous steroid regimen in the treatment of acute Crohn's disease
12. Oral budesonide for active Crohn's disease
13. A comparison of budesonide with prednisolone for active Crohn's disease
14. Oral budesonide is as effective as oral prednisolone in active Crohn's disease
15. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis and experimental intestinal inflammation
16. A comparative study of metronidazole and sulfasalazine for active Crohn's disease: The cooperative Crohn's disease study in Sweden. II. Result
17. Double-blind placebo controlled trial of metronidazole in Crohn's disease
18. An antibiotic regimen for the treatment of active Crohn's disease: A randomized, controlled clinical trial of metronidazole plus ciprofloxacin
19. Combination ciprofloxacin and metronidazole for active Crohn's disease
20. Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection
21. Probiotic therapy
22. Polymeric enteral diets as primary treatment of active Crohn's disease: A prospective steroid controlled trial
23. Controlled trial of polymeric versus elemental diet in treatment of active Crohn's disease
24. Polymeric versus elemental diet as primary treatment in active Crohn's disease: A randomized, double-blind trial
25. Meta-analysis of enteral nutrition as a primary treatment of active Crohn's disease
26. Supplementary enteral nutrition maintains remission in paediatric Crohn's disease
27. Indications and options of nutritional treatment for Crohn's disease. A comparison of elemental and polymeric diets
28. Crohn's disease: Nutrition and nutritional therapy
29. Treatment of active Crohn's disease by exclusion diet: East Anglian multicentre controlled trial
30. How effective is enteral nutrition in inducing clinical remission in active Crohn's disease? A meta-analysis of the randomized clinical trials
31. Defined-formula diets versus steroids in the treatment of active Crohn's disease: A meta-analysis
32. Initial response and subsequent course of Crohn's disease treated with elemental diet or prednisolone
33. Modulation of intestinal immune system by dietary fat intake: Relevance to Crohn's disease
34. Doubleblind withdrawal trial of azathioprine as maintenance treatment for Crohn's disease
35. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study
36. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis
37. Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease
38. A controlled double blind study of azathioprine in the management of Crohn's disease
39. Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
40. Methotrexate for the treatment of Crohn's disease
41. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease
42. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
43. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
44. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
45. Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease
46. Efficacy of mycophenolate mofetil in patients failing 6-mercaptopurine or azathioprine therapy for Crohn's disease
47. Low-dose cyclosporine for the treatment of Crohn's disease
48. European trial of cyclosporine in chronic active Crohn's disease: A 12-month study
49. Steroid-unresponsive acute attacks of inflammatory bowel disease: Immunomodulation by tacrolimus (FK506)
50. Oral tacrolimus (FK 506) in Crohn's disease complicated by fistulae of the perineum
51. Inflammatory bowel disease revisited: Surgery today and tomorrow
52. Prognosis after surgery for colonic Crohn's disease
53. Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial
54. Long-term outcome after ileocecal resection for Crohn's disease
55. Azathioprine and 6-mercaptopurine in Crohn's disease. A meta-analysis
56. Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae
57. Efficacy of cyclosporin in treatment of fistula in Crohn's disease
58. Metronidazole therapy for Crohn's disease and associated fistulae
59. Infliximab for the treatment of fistulas in patients with Crohn's disease
60. Anorectal Crohn's disease. A long-term perspective
61. Mesalamine in the maintenance treatment of Crohn's disease: A meta-analysis adjusted for confounding variables
62. Prognostic factors for postoperative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC)
63. Is it possible to prevent recurrent Crohn's disease with medical or surgical interventions?
64. Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's Disease Study VI
65. Mesalamine for the prevention of postoperative recurrence: Is nearly there the same as being there?
66. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology
67. Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis
68. Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease
69. Effects of smoking on the presentation and clinical course of inflammatory bowel disease
70. Smoking habits and recurrence in Crohn's disease
71. Decreased severity of Crohn's disease after smoking cessation
72. Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease
73. A placebocontrolled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
74. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease