α-Galactosyl epitope-mediated activation of porcine aortic endothelial cells: Type I activation

Transplantation

Volumn 65, Issue 6, 1998, Pages 844-853

  Palmetshofer, Alois ^a,d   Galili, Uri ^b   Dalmasso, Agustin P ^c   Robson, Simon C ^a   Bach, Fritz H ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHALASIN D; EPITOPE; GALACTOSE; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M ANTIBODY; LECTIN; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; STAUROSPORINE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIBODY RESPONSE; AORTA; ARTICLE; BLOOD; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNE RESPONSE; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; XENOGRAFT;

ACTINS; ANIMALS; ANTIGENS, SURFACE; AORTA; CELLS, CULTURED; CYTOSKELETON; DISACCHARIDES; ENDOTHELIUM, VASCULAR; GLYCOCONJUGATES; INTERCELLULAR JUNCTIONS; LECTINS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NF-KAPPA B; PHOSPHOTYROSINE; PLANT LECTINS; SWINE;

EID: 0032571264     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199803270-00013     Document Type: Article

References (58)

1. Dalmasso AP, Vercellotti GM, Fischel RJ, Bolman RM, Bach FH, Platt JL. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am J Pathol 1992; 140: 1157.
2. Bach FH, Blakely ML, Vanderwerf WJ, et al. Xenotransplantation: problems posed by endothelial cell activation. Transplant Proc 1994; 26: 1029.
3. Bach FH, Robson SC, Ferran C, et al. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 1994; 141: 5.
4. Bach FH, Robson SC, Ferran C, et al. Xenotransplantation: endothelial cell activation and beyond. Transplant Proc 1995; 27: 77.
5. Platt JL, Lindman BJ, Geller RL, et al. The role of natural antibodies in the activation of xenogenic endothelial cells. Transplantation 1991; 52: 1037.
6. Platt JL. A perspective on xenograft rejection and accommodation. Immunol Rev 1994; 141: 127.
7. Galili U, Clark MR, Shohet SB, Buehler J, Macher BA. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci USA 1987; 84: 1369.
8. Sandrin MS, Vaughan HA, Dabkowski PL, McKenzie I. Anti-pig IgM antibodies in human serum react predominantly with gal(alpha-1-3)gal epitopes. Proc Natl Acad Sci USA 1993; 90: 11391.
9. Galili U. Interaction of the natural anti-gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol Today 1993; 14: 480.
10. Cooper DK, Koren E, Oriol R. Oligosaccharides and discordant xenotransplantation [Review]. Immunol Rev 1994; 141: 31.
11. Vaughan HA, Loveland BE, Sandrin MS. Gal α(1,3)Gal is the major xenoepitope expressed on pig endothelial cells recognized by naturally occurring cytotoxic human antibodies. Transplantation 1994; 58: 879.
12. Collins BH, Cotterell AH, McCurry KR, et al. Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection. J Immunol 1995; 154: 5500.
13. Oriol R, Ye Y, Koren E, Cooper D. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993; 56: 1433.
14. Galili U, Shohet SB, Kobrin E, Stults CL, Macher BA. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 1988; 263: 17755.
15. Galili U, Rachmilewitz EA, Peleg A, Flechner I. A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J Exp Med 1984; 160: 1519.
16. Galili U, Macher BA, Buehler J, Shohet SB. Human natural anti-alpha-galactosyl IgG: II. The specific recognition of alpha (1-3)-linked galactose residues. J Exp Med 1985; 162: 573.
17. Galili U, Anaraki F, Thall A, Hill BC, Radic M. One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody. Blood 1993; 82: 2485.
18. Galili U, Gregory CR, Morris RE. Contribution of anti-Gal to primate and human IgG binding to porcine endothelial cells. Transplantation 1995; 60: 210.
19. Platt JL, Lindman BJ, Bach FH. Natural antibody targets on discordant endothelium: molecular characterization and consequences of antibody binding. Transplant Proc 1991; 23: 815.
20. Vaughan HA, McKenzie IF, Sandrin MS. Biochemical studies of pig xenoantigens detected by naturally occurring human anti-bodies and the galactose α(1-3)galactose reactive lectin. Transplantation 1995; 59: 102.
21. Leventhal JR, John R, Fryer JP, et al. Removal of baboon and human antiporcine IgG and IgM natural antibodies by immunoadsorption: results of in vitro and in vivo studies. Transplantation 1995; 59: 294.
22. Kroshus TJ, Dalmasso AP, Leventhal JR, John R, Matas AJ, Bolman RM. Antibody removal by column immunoabsorption prevents tissue injury in an ex vivo model of pig-to-human xenograft hyperacute rejection. J Surg Res 1995; 59: 43.
23. Watier H, Guillaumin JM, Piller F, et al. Removal of terminal α-galactosyl residues from xenogeneic porcine endothelial cells: decrease in complement-mediated cytotoxicity but persistence of IgG1-mediated antibody-dependent cell-mediated cytotoxicity. Transplantation 1996; 62: 105.
24. Kroshus TJ, Bolman RR, Dalmasso AP. Selective IgM depletion prolongs organ survival in an ex vivo model of pig-to-human xenotransplantation. Transplantation 1996; 62: 5.
25. Pober JS, Cotran RS. Cytokines and endothelial cell biology [Review]. Physiol Rev 1990; 70: 427.
26. Saadi S, Platt JL. Transient perturbation of endothelial integrity induced by natural antibodies and complement. J Exp Med 1995; 181: 21.
27. Maynard JR, Dreyer BE, Stemerman MB, Pitlick FA. Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts. Blood 1977; 50: 387.
28. Platt JL, Lindman BJ, Chen H, Spitalnik SL, Bach FH. Endothelial cell antigens recognized by xenoreactive human natural antibodies. Transplantation 1990; 50: 817.
29. Holzknecht ZE, Platt JL. Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies. J Immunol 1995; 154: 4565.
30. Ishida T, Peterson TE, Kovach NL, Berk BC. MAP kinase activation by flow in endothelial cells: role of beta 1 integrins and tyrosine kinases. Circ Res 1996; 79: 310.
31. Morino N, Mimura T, Hamasaki K, et al. Matrix/integrin interaction activates the mitogen-activated protein kinase, p44Erk-1 and p42Erk-2. J Biol Chem 1995; 270: 269.
32. Chen Q, Kinch MS, Lin TH, Burridge K, Juliano RL. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 1994; 269: 26602.
33. Baeuerle PA, Baltimore D. NF-κB: ten years after. Cell 1996; 87: 13.
34. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers [Review]. FASEB J 1995; 9: 899.
35. Schmitz ML, Baeuerle PA. Multi-step activation of NF-κB/Rel transcription factors [Review]. Immunobiology 1995; 193; 116.
36. Chytil M, Verdine GL. The Rel family of eukaryotic transcription factors. Curr Opin Struct Biol 1996; 6: 91.
37. Berra E, Diaz MM, Lozano J, et al. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J 1995; 14: 6157.
38. Introna M, Mantovani A. Early activation signals in endothelial cells: stimulation by cytokines [Review]. Arterioscler Thromb Vasc Biol 1997; 17: 423.
39. Murphy LA, Goldstein IJ. Five alpha-D-galactopyranosyl-binding isolectins from Bandeiraea simplicifolia seeds. J Biol Chem 1977; 252: 4739.
40. Kisailus EC, Kabat EA. A study of the specificity of Bandeiraea simplicifolia lectin I by competitive-binding assay with blood-group substances and with blood-group A and B active and other oligosaccharides. Carbohydr Res 1978; 67: 243.
41. Vanhove B, deMartin R, Lipp J, Bach FH. Human xenoreactive natural antibodies of the IgM isotype activate pig endothelial cells. Xenotransplant 1994; 1: 17.
42. Stuhlmeier KM, Csizmadia V, Cheng Q, Winkler H, Bach FH. Selective inhibition of E-selectin, ICAM-1, and VCAM-1 in endothelial cells. Eur J Immunol 1994; 24: 2186.
43. Dalmasso AP, He T, Benson BA. Human IgM xenoreactive natural antibodies can induce resistance of porcine endothelial cells to complement-mediated injury. Xenotransplant 1996; 3: 54.
44. Read MA, Whitley MZ, Williams AJ, Collins T. NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation. J Exp Med 1994; 179: 503.
45. Anrather J, Csizmadia V, Brostjan C, Soares MP, Bach FH, Winkler H. Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-κB. J Clin Invest 1997; 99: 763.
46. Brett J, Gerlach H, Nawroth P, Steinberg S, Godman G, Stern D. Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. J Exp Med 1989; 169: 1977.
47. Lampugnani MG, Resnati M, Dejana E, Marchisio PC. The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol 1991; 112: 479.
48. Platt JL. The immunological barriers to xenotransplantation. Crit Rev Immunol 1996; 16: 331.
49. Jewell K, Kapron BC, Jeevaratnam P, Dedhar S. Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins. J Cell Sci 1995; 108: 1165.
50. Kornberg LJ, Earp HS, Turner CE, Prockop C, Juliano RL. Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins. Proc Natl Acad Sci USA 1991; 88: 8392.
51. Sundberg C, Rubin K. Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors. J Cell Biol 1996; 132: 741.
52. Richardson A, Parsons JT. Signal transduction through integrins: a central role for focal adhesion kinase? [Review]. BioEssays 1995; 17: 229.
53. Parsons JT. Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins [Review]. Curr Opin Cell Biol 1996; 8: 146.
54. Nojima Y, Morino N, Mimura T, et al. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J Biol Chem 1995; 270: 15398.
55. Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J Biol Chem 1995; 270: 22259.
56. Galili U, LaTemple DC, Walgenbach AW, Stone KR. Porcine and bovine cartilage transplants in cynomolgus monkey: II. Changes in anti-Gal response during chronic rejection. Transplantation 1997; 63: 646.
57. Hawker JJ, Granger HJ. Tyrosine kinase inhibitors impair fibroblast growth factor signaling in coronary endothelial cells. Am J Physiol 1994; 266: 107.
58. Xia Y, Gil SG, Carter WG. Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. J Cell Biol 1996; 132: 727.