Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs

American Journal of Respiratory Cell and Molecular Biology

Volumn 18, Issue 4, 1998, Pages 479-488

  Ermert, Leander ^a   Ermert, M ^b   Goppelt Struebe, M ^b   Walmrath, D ^b   Grimminger, F ^b   Steudel, W ^b   Ghofrani, H A ^b   Homberger, C ^b   Duncker, H R ^b   Seeger, W ^b  

^a Inst fuer Anatomie und Zellbiologie   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHUS;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ISOENZYME; MEMBRANE PROTEIN; MESSENGER RNA; PROSTAGLANDIN SYNTHASE; PTGS1 PROTEIN, RAT; RNA DIRECTED DNA POLYMERASE;

ANIMAL; ARTICLE; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; IMMUNOHISTOCHEMISTRY; LUNG; MALE; METABOLISM; METHODOLOGY; POLYMERASE CHAIN REACTION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LUNG; MALE; MEMBRANE PROTEINS; POLYMERASE CHAIN REACTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA-DIRECTED DNA POLYMERASE;

EID: 0032036338     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.18.4.2939     Document Type: Article

References (56)

1. Warnock, L. J., and G. W. Hunninghake. 1995. Multiple second messenger pathways regulate IL-1 beta-induced expression of PGHS-2 mRNA in normal human skin fibroblasts. J. Cell Physiol. 163:172-178.
2. Goppelt-Struebe, M. 1995. Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression. Prostaglandins Leuk. Essent. Fatty Acids 52:213-222.
3. Thivierge, M., and M. Rola-Pleszczynski. 1995. Up-regulation of inducible cyclooxygenase gene expression by platelet-activating factor in activated rat alveolar macrophages. J. Immunol. 154:6593-6599.
4. Endo, T., F. Ogushi, S. Sone, T. Ogura, Y. Taketani, Y. Hayashi, N. Ueda, and S. Yamamoto. 1995. Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 12:358-365.
5. Lee, S. H., E. Soyoola, P. Chanmugam, S. Hart, W. Sun, H. Zhong, S. Liou, D. Simmons, and D. Hwang. 1992. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem. 267:25934-25938.
6. Kennedy, B. P., C. C. Chan, S. A. Culp, and W. A. Cromlish. 1993. Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA. Biochem. Biophys. Res. Commun. 197:494-500.
7. Appleton, I., A. Tomlinson, J. A. Mitchell, and D. A. Willoughby. 1995. Distribution of cyclooxygenase isoforms in murine chronic granulomatous inflammation: implications for future anti-inflammatory therapy. J. Pathol. 176:413-420.
8. Jones, D. A., D. P. Carlton, T. M. McIntyre, G. A. Zimmerman, and S. M. Prescott. 1993. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268:9049-9054.
9. Feng, L., W. Sun, Y. Xia, W. W. Tang, P. Chanmugam, E. Soyoola, C. B. Wilson, and D. Hwang. 1993. Cloning two isoforms of rat cyclooxygenase: Differential regulation of their expression. Arch. Biochem. Biophys. 307:361-368.
10. Mitchell, J. A., P. Akarasereenont, C. Thiemermann, R. J. Flower, and J. R. Vane. 1993. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A. 90:11693-11697.
11. Klein, T., R. M. Nüsing, J. Pfeilschifter, and V. Ullrich. 1994. Selective inhibition of cyclooxygenase 2. Biochem. Pharmacol. 48:1605-1610.
12. Gierse, J. K., S. D. Hauser, D. P. Creely, C. Koboldt, S. H. Rangwala, P. C. Isakson, and K. Seibert. 1995. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem. J. 305:479-484.
13. Seeger, W., H. Walter, N. Suttorp, M. Muhly, and S. Bhakdi. 1989. Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs. J. Clin. Invest. 84:220-227.
14. Holtzman, M. J. 1991. Arachidonic acid metabolism: implications of biological chemistry for lung function and disease. Am. Rev. Respir. Dis. 143:188-203.
15. Walmrath, D., H.-A. Ghofrani, S. Rosseau, H. Schütte, A. Cramer, W. Kaddus, F. Grimminger, S. Bhakdi, and W. Seeger. 1994. Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo-and exotoxin. J. Exp. Med. 180:1437-1443.
16. Christman, B. W., C. D. McPherson, J. H. Newman, G. A. King, G. R. Bernard, B. M. Groves, and J. E. Loyd. 1992. An imbalance between the excretion or thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 327:70-75.
17. Wilborn, J., L. J. Crofford, M. D. Burdick, S. L. Kunkel, R. M. Strieter, and M. Peters-Golden. 1995. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J. Clin. Invest. 95: 1861-1868.
18. Sultorp, N., U. Weber, T. Welsch, and C. Schudt. 1993. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J. Clin. Invest. 91:1421-1428.
19. Devalia, J. L., R. J. Sapsford, D. R. Cundell, C. Rusznak, A. M. Campbell, and R. J. Davies. 1993. Human bronchial epithelial cell dysfunction following in vitro exposure to nitrogen dioxide. Eur. Respir. J. 6:1308-1316.
20. Arias-Diaz, J., E. Vara, C. Garcia, and J. L. Balibrea. 1994. Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. J. Clin. Invest. 94:244-250.
21. Hempel, S. L., M. M. Monick, B. He, T. Yano, and G. W. Hunninghake. 1994. Synthesis of prostaglandin H synthase-2 by human alveolar macrophages in response to lipopolysaccharide is inhibited by decreased cell oxidant tone. J. Biol. Chem. 269:32979-32984.
22. Wilborn, J., D. L. DeWitt, and M. Peters-Golden. 1995. Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages. Am. J. Physiol. 268:L294-L301.
23. Tamaoki, J., A. Chiyotani, K. Kobayashi, N. Sakai, T. Kanemura, and T. Takizawa. 1992. Effect of indomethacin on bronchorrhea in patients with chronic bronchitis, diffuse panbronchiolitis, or bronchiectasis. Am. Rev. Respir. Dis. 145:548-552.
24. Holtzman, M. J. 1992. Arachidonic acid metabolism in airway epithelial cells. Annu. Rev. Physiol. 54:303-329.
25. Barnes, P. J. 1995. Molecular mechanisms of antiasthma therapy. Ann. Med. 27:531-535.
26. Thien, F. C., and E. H. Walters. 1995. Eicosanoids and asthma: an update. Prostaglandins Leuk. Essent. Fatty Acids 52:271-288.
27. O'Neill, G. P., and A. W. Ford-Hutchinson. 1993. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330: 156-160.
28. Mitchell, J. A., M. G. Belvisi, P. Akarasereenont, R. A. Robbins, O. J. Kwon, J. Croxtall, P. J. Barnes, and J. R. Vane. 1994. Induction of cyclooxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br. J. Pharmacol. 113:1008-1014.
29. Hempel, S. L., M. M. Monick, and G. W. Hunninghake. 1994. Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J. Clin. Invest. 93:391-396.
30. O'Sullivan, M. G., F. H. Chilton, E. M. Huggins, Jr., and C. E. McCall. 1992. Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase. J Biol. Chem. 267:14547-14550.
31. National Institutes of Health. 1985. Guide for the Care and Use of Laboratory Animals. U.S. Government Printing Office, Washington, DC. NIH Publication No. 86-23. (revised 1985).
32. Beiche, F., S. Scheuerer, K. Brune, G. Geisslinger, and M. Goppelt-Struebe. 1996. Upregulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett. 390:165-169.
33. Springall, D. R., B. Bhatnagar, J. Wharton, Q. Hamid, S. Gulbenkian, M. Hedges, L. Meleagros, S. R. Bloom, and J. M. Polak. 1988. Expression of the atrial natriuretic peptide gene in the cardiac muscle of rat extrapulmonary and intrapulmonary veins.Thorax 43:44-52.
34. Paes de Almeida, O., G. M. Böhm, M. de Paula Carvalho, and A. Paes de Carvalho. 1975. The cardiac muscle in the pulmonary vein of the rat: a morphological and electrophysiological study. J. Morphol. 145:409-434.
35. Meyrick, B., A. Hislop, and L. Reid. 1978. Pulmonary arteries of the normal rat: the thick walled oblique muscle segment. J. Anat. 125:209-221.
36. DeFouw, D. O. 1988. Structural heterogeneity within the pulmonary microcirculation of the normal rat. Anat. Rec. 221:645-654.
37. Michel, R. P. 1982. Arteries and veins of the normal dog lung: qualitative and quantitative structural differences. Am. J. Anat. 164:227-241.
38. Alpert, S. E., and R. W. Walenga. 1995. Ozone exposure of human tracheal epithelial cells inactivates cyclooxygenase and increases 15-HETE production. Am. J. Physiol. 269:L734-L743.
39. Robinson, C., and S. T. Holgate. 1991. Regulation by prostanoids. In R. G. Crystal. J. B. West, et al., editors. The Lung. Raven Press, New York, 941-951.
40. Jackson, B. A., R. H. Goldstein, R. Roy, M. Cozzani, L. Taylor, and P. Polgar. 1993. Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture. Biochem. BioPhys. Res. Commun. 197:1465-147-4.
41. Blanco, A., A. Habib, S. Levy-Toledano, and J. Maclouf. 1995. Involvement of tyrosine kinases in the induction of cyclo-oxygenase-2 in human endothelial cells. Biochem. J. 312:419-423.
42. Ohkawara, Y., K. Yamauchi, Y. Tanno, G. Tamura, H. Ohtani, H. Nagura, K. Ohkuda, and T. Takishima. 1992. Human lung mast cells and pulmonary macrophages produce tumor necrosis factor-α in sensitized lung tissue after IgE receptor triggering. Am. J. Respir. Cell Mol. Biol. 7:385-392.
43. Peters, S. P., D. W. MacGlashan, Jr., E. S. Schulman, R. P. Schleimer, E. C. Hayes, J. Rokach, N. F. Adkinson, Jr., and L. M. Lichtenstein. 1984. Arachidonic acid metabolism in purified human lung mast cells. J. Immunol. 132:1972-1979.
44. 2 generation after activation of rat and human mast cells with anti-IgE. J. Immunol. 129:1627-1631.
45. Dvorak, A. M., H. F. Dvorak, S. P. Peters, E. S. Shulman, D. W. MacGlashan, Jr., K. Pyne, V. S. Harvey, S. J. Galli, and L. M. Lichtenstein. 1983. Lipid bodies: Cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. J. Immunol. 131:2965-2976.
46. Dvorak, A. M., E. Morgan, R. P. Schleimer, S. W. Ryeom, L. M. Lichtenstein, and P. F. Weller. 1992. Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to non-membrane-bound cytoplasmic lipid bodies in human lung mast cells, alveolar macrophages, type II pneumocytes, and neutrophils. J. Histochem. Cytochem. 40:759-769.
47. Marshall, B. E., C. Marshall, F. Frasch, and C. W. Hanson. 1994. Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution: 1. Physiologic concepts. Intensive Care Med. 20:291-297.
48. Marshall, B. E., C. W. Hanson, F. Frasch, and C. Marshall. 1994. Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution: 2. Pathophysiology. Intensive Care Med. 20:379-389.
49. Walenga, R. W., M. Kester, E. Coroneos, S. Butcher, R. Dwivedi, and C. Statt. 1996. Constitutive expression of prostaglandin endoperoxide G/H synthetase (PGHS)-2 but not PGHS-1 in human tracheal epithelial cells in vitro. Prostaglandins 52:341-359.
50. Asano, K., C. M. Lilly, and J. M. Drazen. 1996. Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells. Am. J. Physiol. 271:L126-L131.
51. Demoly, P., D. Jaffuel, N. Lequeux, B. Weksler, C. Créminon, F.-B. Michel, P. Godard, and J. Bousquet. 1997. Prostaglandin H synthase 1 and 2 immunoreactivities in the bronchial mucosa of asthmatics. Am. J. Respir. Crit. Care Med. 155:670-675.
52. Ermert, L., W. Seeger, and H.-R. Duncker. 1993. Computer-assisted morphometry of the intracapillary leukocyte pool in the rabbit lung. Cell Tissue Res. 271:469-476.
53. Ermert, L., H.-R. Duncker, S. Rosseau, H. Schütte, and W. Seeger. 1994. Morphometric analysis of pulmonary intracapillary leukocyte pools in ex vivo-perfused rabbit lungs. Am. J. Physiol. 267:L64-L70.
54. Arias-Negrete, S., K. Keller, and K. Chadee. 1995. Proinflammatory cytokines regulate cyclooxygenasc-2 mRNA expression in human macrophages. Biochem. Biophys. Res. Commun. 208:582-589.
55. Iseki, S. 1995. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. Histochem. J. 27:323-328.
56. Yamagata, K., K. I. Andreasson, W. E. Kaufmann, C. A. Barnes, and P. F. Worley. 1993. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11:371-386.