Human xenospecific T suppressor cells inhibit T helper cell proliferation to porcine aortic endothelial cells, and NF-κB activity in porcine APC

Human Immunology

Volumn 62, Issue 5, 2001, Pages 470-478

  Ciubotariu, Rodica ^a   Li, Jianfeng ^a   Colovai, Adriana I ^a   Platt, Jeffrey L ^b   Cortesini, Raffaello ^c   Suciu Foca Cortesini, Nicole ^a  

^a The New York Presbyterian Hospital   (United States)

^b Dept Surg Immunol Pediat M ^*  (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cellular activation; Endothelial cells; Human T lymphocytes; Tolerance suppression

Indexed keywords

CD86 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SYNAPTOTAGMIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CELL INTERACTION; DOWN REGULATION; ENDOTHELIUM CELL; HELPER CELL; LYMPHOCYTE PROLIFERATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SUPPRESSOR CELL; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, CD86; AORTA; CD40 LIGAND; CELL DIVISION; CELL TRANSPLANTATION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; SIGNAL TRANSDUCTION; SWINE; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION, GENETIC; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 0035026356     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(01)00238-5     Document Type: Article

References (26)

1. + T Helper and a T-Killer cell. Nature 393:474, 1998.
2. Clark EA, Ledbetter JA. How B and T cells talk to each other. Nature 367:425, 1994.
3. + T cells that induces contact-dependent B cell differentiation (help). J Exp Med 175:1081, 1992.
4. - dependent signal. J Exp Med 177:925, 1993.
5. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 392:245, 1998.
6. Jaiswal AJ, Craft M. CD40 ligand induction on T cell subsets by peptide presenting B cells. J Immunol 159:2282, 1997.
7. Yang Y, Wilson JM. CD40L-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273:1862, 1996.
8. - T cells. Int Immunology 10:775, 1998.
9. Liu Z, Tugulea S, Cortesini R, Lederman S, Suciu-Foca N. Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells. Human Immunol 60:568, 1999.
10. -. Transplantation 69:1304, 2000.
11. - regulatory cells. J Immunol 161:5193, 1998.
12. Soheyla S, Holzknecht RA, Patte CP, Stern DM, Platt JL. Complement-mediated Regulation of Tissue Factor Activity in Endothelium. J Exp Med 182:1807, 1995.
13. Bravery C, Batten P, Yacaub M, Rose M. Direct Recognition of SLA and HLA-like class II antigens of porcine endothelium by human T cells results in T cell activation and release of IL2. Transplantation 60:1024, 1995.
14. Li J, Qu X, Schmidt AM. Sp1-binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells. J Biol Chem 273:30870, 1998.
15. Maher S, Karmon K, Min W, Hughes CW, Pober JS, Bothwell ALM. Porcine Endothelial CD86 is a major costimulator of xenogeneic human T cells. J Immunol 157:3838, 1996.
16. Li J, Liu Z, Jiang S, Cortesini R, Lederman S, Suciu-Foca N. T suppressor lymphocytes inhibit NF-κB mediated transcription of CD86 gene in APC. J Immunol 163:6386, 1999.
17. Sachs DH. The pig as a xenograph T donor. Pathol Biol 42:217, 1994.
18. Platt JL. The immunological barriers to xenotransplantation. Crit Rev Immunol 16:331, 1996.
19. Morgan BP. Complement regulatory molecules: application to therapy and transplantation. Immunology Today 16:257, 1995.
20. Bothwell ALM. Characterization of human antiporcine immune response. Immunol Res 19(2-3):223, 1999.
21. Dorling A, Binns R, Lechler RI. Cellular xenoresponses: although vigorous, direct human T cell anti-pig primary xenoresponses are significantly weaker than equivalent alloresponses. Xenotransplantation 3:143, 1996.
22. Yamada K, Sachs D, Dersimonion H. Human anti-porcine xenogeneic T cell response. J Immunol 155, 1995.
23. Takahashi T, Saadi S, Platt J. Recent advances in the immunology of xenotransplantation. Immunol Res 163:273, 1997.
24. Platt J. New direction for organ transplantation. Nature 392:11, 1998.
25. Murray AG, Khodadonst MM, Pober JS, Bothwell ALM. Porcine aortic endothelial cells activate human T cells; direct presentation of MHC antigens and costimulation by ligands from human CD2 and CD28. Immunity 1:57, 1994.
26. Pober J. Immunobiology of Human Vascular Endothelium. Immunol Res 19(2-3):225, 1999.